Population based study on arsenic induced blood samples employing hybrid metaheuristic optimization based ML approach

2019 ◽  
Author(s):  
Anirban Dey ◽  
Kaushik Das Sharma ◽  
Tamalika Sanyal ◽  
Pritha Bhattacharjee Jr ◽  
Pritha Bhattacharjee
Keyword(s):  
Population Based ◽  
Population Based Study ◽  
Blood Samples ◽  
Hybrid Metaheuristic ◽  
Metaheuristic Optimization

Assessment of Circulating t(14;18)-Positive Cells in 4152 Individuals without Lymphoma Shows Association with Age and Gender, but Not with Smoking Status: Results From the Population-Based Study of Health in Pomerania (SHIP).

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 3921-3921
Author(s):  
Carsten Hirt ◽  
Kerstin Weitmann ◽  
Frank Schueler ◽  
Christian Späth ◽  
Wolfgang Hoffmann ◽  
...  
Keyword(s):  
Risk Factors ◽  
Conflicts Of Interest ◽  
Smoking Status ◽  
Epidemiological Data ◽  
Population Based ◽  
Geographical Differences ◽  
Population Based Study ◽  
Study Region ◽  
Blood Samples ◽  
Significant Difference

Abstract Abstract 3921 Poster Board III-857 The t(14;18)(BCL2/IgH) translocation is the genetic hallmark of follicular lymphoma (FL). Circulating t(14;18)-positive cells can not only be detected in FL patients but also in healthy subjects without lymphoma. Several epidemiological and molecular studies suggest that these t(14;18)-positive cells might represent lymphoma precursor cells and are associated with known FL risk factors like age and geographical differences in lymphoma incidence. We used epidemiological data and blood samples of a population-based study to verify associations of FL risk factors and t(14;18)-positive cells reported so far and to test for new associations. The study of health in Pomerania (SHIP) collects epidemiological data, a basic health status and blood samples from 4310 randomly selected inhabitants of the study region in the northeastern part of Germany. We tested buffy coat-DNA samples from 4152 study participants (median age 50 years, range 20-81 years, 2100 women) by real-time PCR for the presence and frequency of t(14;18)-positive cells. t(14;18)-PCR results were evaluable from 2620 subjects, 1533 subjects were tested positive (58.1%, median number of t(14;18)-positive cells in positive subjects 3.9 per million nucleated cells, range 0.6 – 9299 per million nucleated cells). t(14;18)-prevalence was lowest in the age group 20-29 years (42.2%) and increased up to the group 50-59 years (67.0%) but did not further increase up to the age of 81 years. In accordance with previous reports there was a significant increase of the t(14;18)-frequency with age up to the age of 69 years (linear regression, p< 0.0001) in this study. In the SHIP cohort, t(14;18)-prevalence was lower in females compared to males (53.2% versus 63.5%, p< 0.0001), but there was no significant difference in t(14;18)-frequency between males and females. Smoking status (current, former and never smoker) had no influence on t(14;18)-prevalence or frequency. This study confirms the association of t(14;18)-prevalence with age and shows for the first time that the t(14;18)-prevalence in females is lower than in males. The later finding parallels the observation of a lower FL incidence in females. In contrast to previous studies, smoking was not associated with detection of t(14;18)-positive cells when the analysis was adjusted for age and sex. In summary, this study confirms that the prevalence of t(14;18)-positive cells in non-lymphoma subjects is associated with established FL risk factors. Thus our report adds to the accumulating evidence that circulating t(14;18)-positive cells in non-lymphoma subjects may represent a biomarker of FL risk. Disclosures: No relevant conflicts of interest to declare.

Risk of fracture in Crohn's disease: A population-based study

2001 ◽  
Vol 120 (5) ◽  
pp. A628-A628
Author(s):  
E LOFTUSJR ◽  
C CROWSON ◽  
W SANDBORN ◽  
W TREAMINE ◽  
W OFALLON ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Population Based ◽  
Population Based Study ◽  
Risk Of Fracture

264: Population-Based Study of Renal Cell Carcinoma and Prostate Cancer in the Same Patient

2005 ◽  
Vol 173 (4S) ◽  
pp. 73-73 ◽  
Author(s):  
Daniel A. Barocas ◽  
Farhang Rabbani ◽  
Douglas S. Scherr ◽  
E. Darracott Vaughan
Keyword(s):  
Prostate Cancer ◽  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Population Based ◽  
Population Based Study

1480: The Association of Body Mass Index and Serum Prostate Specific Antigen Levels in a Population-Based Study

2005 ◽  
Vol 173 (4S) ◽  
pp. 401-401
Author(s):  
Javier Hernandez ◽  
Jacques Baillargeon ◽  
Brad Pollock ◽  
Alan R. Kristal ◽  
Patrick Bradshaw ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Prostate Specific Antigen ◽  
Body Mass ◽  
Specific Antigen ◽  
Population Based ◽  
Population Based Study ◽  
Serum Prostate Specific Antigen

Psychomotor development and minor anomolies in children exposed to antiepileptic drugs in utero: a population-based study

2000 ◽  
Vol 42 (5) ◽  
pp. 356-356
Author(s):  
Katarina Wide ◽  
Birger Winbladh ◽  
Torbjörn Tomson ◽  
Kerstin Sars-Zimmer ◽  
Eva Berggren
Keyword(s):  
Antiepileptic Drugs ◽  
Population Based ◽  
In Utero ◽  
Psychomotor Development ◽  
Population Based Study

A Population-based Study of 538 Patients with Newly Detected Urinary Bladder Neoplasms Followed during 5 Years

2003 ◽  
Vol 37 (3) ◽  
pp. 195-201 ◽  
Author(s):  
Per Larsson ◽  
Hans Wijkström ◽  
Andreas Thorstenson ◽  
Jan Adolfsson ◽  
Ulf Norming ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Bladder Neoplasms ◽  
Urinary Bladder Neoplasms ◽  
Population Based ◽  
Population Based Study

No relation between biomarkers at age 47–49 and aortic diameter after 14–19 years of follow-up – a population-based study

VASA ◽  
2017 ◽  
Vol 46 (4) ◽  
pp. 291-295 ◽  
Author(s):  
Soumia Taimour ◽  
Moncef Zarrouk ◽  
Jan Holst ◽  
Olle Melander ◽  
Gunar Engström ◽  
...  
Keyword(s):  
Population Based ◽  
Aortic Diameter ◽  
Aortic Dilatation ◽  
Population Based Study ◽  
Reactive Protein ◽  
Abdominal Aortic ◽  
Long Term Follow Up ◽  
Old Men

Abstract. Background: Biomarkers reflecting diverse pathophysiological pathways may play an important role in the pathogenesis of abdominal aortic aneurysm (aortic diameter ≥30 mm, AAA), levels of many biomarkers are elevated and correlated to aortic diameter among 65-year-old men undergoing ultrasound (US) screening for AAA. Probands and methods: To evaluate potential relationships between biomarkers and aortic dilatation after long-term follow-up, levels of C-reactive protein (CRP), proneurotensin (PNT), copeptin (CPT), lipoprotein-associated phospholipase 2 (Lp-PLA2), cystatin C (Cyst C), midregional proatrial natriuretic peptide (MR-proANP), and midregional proadrenomedullin (MR-proADM) were measured in 117 subjects (114 [97 %] men) aged 47–49 in a prospective population-based cohort study, and related to aortic diameter at US examination of the aorta after 14–19 years of follow-up. Results: Biomarker levels at baseline did not correlate with aortic diameter after 14–19 years of follow up (CRP [r = 0.153], PNT [r = 0.070], CPT [r = –.156], Lp-PLA2 [r = .024], Cyst C [r = –.015], MR-proANP [r = 0.014], MR-proADM [r = –.117]). Adjusting for age and smoking at baseline in a linear regression model did not reveal any significant correlations. Conclusions: Tested biomarker levels at age 47–49 were not associated with aortic diameter at ultrasound examination after 14–19 years of follow-up. If there are relationships between these biomarkers and aortic dilatation, they are not relevant until closer to AAA diagnosis.

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