Assessment of Circulating t(14;18)-Positive Cells in 4152 Individuals without Lymphoma Shows Association with Age and Gender, but Not with Smoking Status: Results From the Population-Based Study of Health in Pomerania (SHIP).

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 3921-3921
Author(s):  
Carsten Hirt ◽  
Kerstin Weitmann ◽  
Frank Schueler ◽  
Christian Späth ◽  
Wolfgang Hoffmann ◽  
...  
Keyword(s):  
Risk Factors ◽  
Conflicts Of Interest ◽  
Smoking Status ◽  
Epidemiological Data ◽  
Population Based ◽  
Geographical Differences ◽  
Population Based Study ◽  
Study Region ◽  
Blood Samples ◽  
Significant Difference

Abstract Abstract 3921 Poster Board III-857 The t(14;18)(BCL2/IgH) translocation is the genetic hallmark of follicular lymphoma (FL). Circulating t(14;18)-positive cells can not only be detected in FL patients but also in healthy subjects without lymphoma. Several epidemiological and molecular studies suggest that these t(14;18)-positive cells might represent lymphoma precursor cells and are associated with known FL risk factors like age and geographical differences in lymphoma incidence. We used epidemiological data and blood samples of a population-based study to verify associations of FL risk factors and t(14;18)-positive cells reported so far and to test for new associations. The study of health in Pomerania (SHIP) collects epidemiological data, a basic health status and blood samples from 4310 randomly selected inhabitants of the study region in the northeastern part of Germany. We tested buffy coat-DNA samples from 4152 study participants (median age 50 years, range 20-81 years, 2100 women) by real-time PCR for the presence and frequency of t(14;18)-positive cells. t(14;18)-PCR results were evaluable from 2620 subjects, 1533 subjects were tested positive (58.1%, median number of t(14;18)-positive cells in positive subjects 3.9 per million nucleated cells, range 0.6 – 9299 per million nucleated cells). t(14;18)-prevalence was lowest in the age group 20-29 years (42.2%) and increased up to the group 50-59 years (67.0%) but did not further increase up to the age of 81 years. In accordance with previous reports there was a significant increase of the t(14;18)-frequency with age up to the age of 69 years (linear regression, p< 0.0001) in this study. In the SHIP cohort, t(14;18)-prevalence was lower in females compared to males (53.2% versus 63.5%, p< 0.0001), but there was no significant difference in t(14;18)-frequency between males and females. Smoking status (current, former and never smoker) had no influence on t(14;18)-prevalence or frequency. This study confirms the association of t(14;18)-prevalence with age and shows for the first time that the t(14;18)-prevalence in females is lower than in males. The later finding parallels the observation of a lower FL incidence in females. In contrast to previous studies, smoking was not associated with detection of t(14;18)-positive cells when the analysis was adjusted for age and sex. In summary, this study confirms that the prevalence of t(14;18)-positive cells in non-lymphoma subjects is associated with established FL risk factors. Thus our report adds to the accumulating evidence that circulating t(14;18)-positive cells in non-lymphoma subjects may represent a biomarker of FL risk. Disclosures: No relevant conflicts of interest to declare.

scholarly journals 1504. Epidemiology and Etiology of Pyogenic Liver Abscess in the Calgary Health Zone: A Population-Based Study

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S548-S548
Author(s):  
Jennifer A Losie ◽  
John Lam ◽  
Dan Gregson ◽  
Michael Parkins
Keyword(s):  
Risk Factors ◽  
Liver Abscess ◽  
Klebsiella Oxytoca ◽  
Epidemiological Data ◽  
Pyogenic Liver Abscess ◽  
Population Based ◽  
Population Based Study ◽  
Streptococcus Anginosus ◽  
Health Zone ◽  
General Populations

Abstract Background Pyogenic liver abscess (PLA) is a significant cause of morbidity and mortality. Epidemiological data regarding risk factors and outcome determinants are often ascertained from referral population bases. We utilized a population-based study design to better understand PLA. Methods Calgary Health Zone (CHZ) residents ≥18 years of age (population ~1.3 million) who were hospitalized with PLA in 2017 were included. Charts were manually reviewed to determine demographics and clinical outcomes. Univariate and multivariate logistic regression were used to assess for factors associated with 30-day mortality using STATA 15.1 (College Stn., TX). Results Forty-four patients with PLA were identified (39% female, median age 61 [IQR 56–68] years) corresponding to an incidence rate of 3.7 cases per 100,000 population. Prevalent co-morbidities with PLA included; hemodialysis dependence (4.5%), cancer (25%), diabetes (23%), and cirrhosis (6.8%), each of which was significantly more common (P < 0.05) than in the general population; 85.3X, 11.2X, 3.6X, 29.9X, respectively. Rates of other comorbidities including ischemic heart disease, COPD, and rheumatoid arthritis did not differ from general populations (P > 0.05). The etiology of PLA was established in 72% of cases, of which biliary was most common (48%). Most (91%) cases had at least one organism identified via blood or liver aspirate culture. The most common organisms were Streptococcus anginosus group (12), Klebsiella pneumoniae (11), Klebsiella oxytoca (6), Escherichia coli (4), and obligate anaerobes (3). Blood cultures were positive in 25/44 (56%) cases. Thirty-day mortality from admission was 11% and had multiple risk factors (Table-1). Conclusion PLA in the CHZ is common and associated with high mortality. Understanding factors influencing PLA occurrence and outcome can assist in correctly identifying and optimally treating patients. Disclosures All authors: No reported disclosures.

scholarly journals Young Women With Breast Cancer in Brazil: A Population‐Based Study Epidemiology of Breast Cancer in Young Women

2021 ◽  
Author(s):  
Rebecca Lapenda do Monte ◽  
Thais Loyola da Silva ◽  
Ythalo Hugo da Silva Santos ◽  
Diana Taissa Marinho Navarro ◽  
Teresa Cristina Andrade de Oliveira ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Young Women ◽  
Young Patients ◽  
Population Based ◽  
Clinical Staging ◽  
Population Based Study ◽  
Study Region ◽  
Poor Region ◽  
Significant Difference ◽  
History Of

Abstract Background: Worldwide, breast cancer is the most frequent cancer in woman. The incidence in young women has been increasing in the last decade, mainly in developing countries. The aim of this study was to report the incidence of breast cancer in young patients (≤ 40 y) from 2007 to 2014 in a poor region of Brazil. Results: There were a total of 660 cases within a period of 8 years, with an average of 82 cases per year, and with median age of 36 years, ranging from 16 to 40 years. The most frequent cases were invasive carcinoma of no special type (87%), stage II (34.2%), positive for the progesterone receptor (PR, 51.6%), and for estrogen receptor (ER, 59.1%) and positive familial history of cancer (44.5%). These patients are mainly from the urban area (90%) and poorly educated (66.6% completed elementary school). Significant differences were observed for overall survival for the independent variables: age group (p = 0.012), clinical staging (p< 0.001), PR (p= 0.003), ER (p= 0.029) and pregnancy (p= 0.021). No significant difference was found between the survival curves of patients HER2+ or HER2-. The standardized rates for age (ASR) per 100,000 was 3.0-5.3%, which is low when compared to the Global Cancer Observatory (ASR 8.3%) or Brazil (ASR 10.8%). Conclusion: although the incidence of young women has increased in the country, especially in the study region, it has remained stable in the population studied in the last 8 years.

scholarly journals Epidemiology of craniopharyngiomas: a population based study in Malta

2021 ◽  
Author(s):  
Sarah Craus ◽  
Mark Gruppetta
Keyword(s):  
Prevalence Rate ◽  
Adult Population ◽  
Epidemiological Data ◽  
Population Based ◽  
Incidence Rates ◽  
Adult Onset ◽  
Population Based Study ◽  
Background Population ◽  
Number Of Patients ◽  
Significant Difference

Background: Despite being benign tumours, craniopharyngiomas are challenging to manage and can cause significant morbidity and mortality in both the paediatric and adult population. The aim of the study was to analyse epidemiology of craniopharyngioma, patient and tumour characteristics through a population-based study in Malta, enabling a better quantification of the disease burden. Method: A thorough research was carried out to identify the number of patients who were diagnosed with craniopharyngiomas. Epidemiological data, including both Standardised incidence rates (SIR) and prevalence rates were established in a well-defined population. For incidence estimates, patients who were diagnosed between 2008 and 2019 were included. The background population formed 4.8 million patient-years at risk. Result: 29 subjects were identified and included in our study. The overall SIR was 0.3/100,000/year, with a higher SIR for males compared to females (0.4/100,000/year and 0.2/100,000/year, respectively). The highest SIR was recorded in the 10-19 year age group. The estimated prevalence rate amounted to 5.27/100,000 people, with a lower prevalence rate for childhood onset when compared to the adult-onset category (2.03/100,000 vs 3.24/100,000 people). The median longest tumour diameter was 31.0mm (IQR 21-41), with statistically significant difference between childhood- and adult-onset disease; 43.0mm (IQR 42.5-47.25) vs 27.0mm (IQR 20.55-31.55) (P=0.011). Conclusion: Through this population-based study, accurate and up-to-date prevalence and incidence rates for craniopharyngiomas are reported. These provide a clearer reflection of the true health burden of the disease.

Possible Risk Factors and Precipitants for Migraine with Aura in Discordant Twin-Pairs: A Population-Based Study

Cephalalgia ◽  
2000 ◽  
Vol 20 (9) ◽  
pp. 821-825 ◽  
Author(s):  
V Ulrich ◽  
J Olesen ◽  
M Gervil ◽  
MB Russell
Keyword(s):  
Risk Factors ◽  
Migraine With Aura ◽  
Twin Study ◽  
Smoking Status ◽  
Bright Light ◽  
Population Based ◽  
Tension Type Headache ◽  
Population Based Study ◽  
Type Headache ◽  
Discordant Twin

The aim of the present study was to detect possible risk factors in migraine with aura (MA) by analysis of discordant twin-pairs. In a recent population-based twin study we established that environmental factors account for approximately 50% of the variation in liability to MA. A cohort of 5360 same-gender twin-pairs from the general population was screened for migraine. All twin-pairs with possible migraine were interviewed by a physician. A questionnaire provided information about living conditions and lifestyle. Of the 169 discordant twin-pairs 51 were monozygotic and 118 were dizygotic twin-pairs. Several putative risk factors—schooling, education, marital status, smoking status and alcohol consumption—showed no association with MA. The presence of migraine without aura or tension-type headache did not increase the risk of MA. Stress and mental tension, and bright light precipitated attacks of MA in, respectively, 44% and 28% of the twins.

scholarly journals PREVALENCE OF CHRONIC KIDNEY DISEASE AMONG COMMUNITY REMOTE AREAS IN SABAH: POPULATION-BASED STUDY

2020 ◽  
Vol 4 (2) ◽  
pp. 69-75
Author(s):  
Nor Ain Mior Nizam ◽  
Malehah Mohd Noh ◽  
Shamsul Bahari Shamsuddin
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Smoking Status ◽  
Significant Risk ◽  
Population Based ◽  
Accurate Information ◽  
Population Based Study ◽  
Remote Areas ◽  
Total Prevalence

In this population-based study, we determined the prevalence of chronic kidney disease of community in remote areas of Ranau, Sabah to have accurate information for health-care planning. It also investigated the association of risk factors with the prevalence of CKD. A sample of 270 individuals, compared to the study of the National Health and Morbidity Survey 2011, of the adult population (over 18 years old) undertaken in West Malaysia. We measured the estimated glomerular filtration rate (eGFR) using this CKD-EPI equation. The total prevalence of chronic kidney disease in this group was 53%. An estimated 3.3% had stage 1 chronic kidney disease (eGFR >90 ml/min per 1.73m2), 32.6% had stage 2 (eGFR 60–89 ml/min per 1.73m2), 4.1% had stage 3 (eGFR 30–59 ml/min per 1.73m2), 7% had stage 4 (eGFR 15–29 ml/min per 1.73m2), and 6% had stage 5 chronic kidney disease (eGFR <15 ml/min per 1.73m2). Only 4% of respondents with chronic kidney disease were aware of their diagnosis. The significant risk factors included family history of kidney disease, alcohol consumption, smoking status, hypertension, diabetes mellitus, and dyslipidemia. Thus, chronic kidney disease in East Malaysia is common and warrants early detection, and treatment to potentially improve outcomes can be implemented.

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