e14716 Background: Provenge (Dendreon Co.) is an autologous cellular vaccine and represents a significant milestone for cancer immunotherapy and generates renewed interest in the field. Chemoimmunotherapy as a highly attractive way for cancer treatment has been studied over years but this is not generated a specific powerful immunotherapy yet. Intensity Modulation of Chemoimmunotherapy (IMCIT) is similarly with Provenge function and plays in kill tumor cells and induces patient’s own immunological effect against micro size cancers more than just Introtumoral Chemotherapy(ITCT) alone. Methods: Introtumoral injection of IMCIT into late stages of liver Cancer (447 cases) which is a proprietary therapeutic regimen composed of three components for intensity modulation of chemoimmunotherapy, i.e., an oxidant, a cytotoxic drug and a hapten. Results: After intratumoral injection, coagulate tumor mass for sustained drug release and drug kills tumor cells, a small molecule hapten binds to these antigens and other large carriers for intensity modulation, then autologous tumor antigens released from the dead tumor cells and trigger immune response as a self-vaccination to further boost systemic humoral and cellular immunity for suppression and eradication of tumor recurrence. For single liver tumor, 6 months survival rate for IMCIT 63.03% and ITCT 36.17%(p<0.01), 12 months survival rate for IMCIT 32.77% and ITCT 21.28% (P.0.05);for mutable liver tumors, 6 months survival rate for IMCIT 54.44% and ITCT 20.93%(p<0.01),12 months survival rate for IMCIT 21.11% and ITCT 6.98%(p<0.05). Therefore, more importantly, IMCIT provides a new option for cancer treatment by integrating local chemotherapeutic effect with systemic anti-tumor immunity; cell death induced by chemotherapeutic drugs is a priming event and allows the injected tumor act as its own vaccine. Conclusions: Introtumoral injection of IMCIT is a safe, aggressive and cost-effective clinical treatment for solid tumors. IMCIT displays the following advantages: clinically effective for single and multiple masses liver cancer and minimal side effects and better quality of life; simple and cost-effective treatment and strong intellectual property position..
Nanoparticles in enhancing microwave imaging and microwave Hyperthermia effect for liver cancer treatment
