Efficient fast-convolution based hybrid carrier system

This study seeks to formulate and evaluate a solid lipid nanoparticle-based, solidified micellar carrier system for oral delivery of cefepime. Cefepime has enjoyed a lot of therapeutic usage in the treatment of susceptible bacterial infections; however, its use is limited due to its administration as an injection only with poor patient compliance. Since oral drug administration encourage high patient compliance with resultant effect in improved therapy, cefepime was formulated as solid lipid microparticles for oral delivery using the concept of solidified micellar carrier system. The carrier system was evaluated based on particle yield, particle size and morphology, encapsulation efficiency (EE %), and thermal analysis using differential scanning calorimeter (DSC). Preliminary microbiological studies were done using gram positive and negative bacteria. In vitro release study was performed using biorelevant media, while in vivo release study was performed in white albino rats. The yield of solid lipid microparticles (SLM) ranged from 84.2 – 98.0 %. The SLM were spherical with size ranges of 3.8 ± 1.2 to 42.0 ± 1.4 µm. The EE % calculated ranged from 83.6 – 94.8 %. Thermal analysis showed that SLM was less crystalline with high potential for drug entrapment. Microbial studies showed that cefepime retained its broad spectrum anti-bacterial activity. In vitro release showed sustained release of cefepime from SLM, and in vivo release study showed high concentration of cefepime released in the plasma of study rats. The study showed that smart engineering of solidified micellar carrier system could be used to improve oral delivery of cefepime.

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Monocyte as an Emerging Tool for Targeted Drug Delivery: A Review

Current Pharmaceutical Design ◽

10.2174/1381612825666190102104642 ◽

2019 ◽

Vol 24 (44) ◽

pp. 5296-5312 ◽

Cited By ~ 5

Author(s):

Fakhara Sabir ◽

Rai K. Farooq ◽

Asim.ur.Rehman ◽

Naveed Ahmed

Keyword(s):

Drug Delivery ◽

Targeted Drug Delivery ◽

The Body ◽

Carrier System ◽

Bone Marrow Precursor ◽

Extensive Introduction ◽

Cancer Inflammation ◽

Targeted Drug ◽

Cluster Of Differentiation

Monocytes are leading component of the mononuclear phagocytic system that play a key role in phagocytosis and removal of several kinds of microbes from the body. Monocytes are bone marrow precursor cells that stay in the blood for a few days and migrate towards tissues where they differentiate into macrophages. Monocytes can be used as a carrier for delivery of active agents into tissues, where other carriers have no significant access. Targeting monocytes is possible both through passive and active targeting, the former one is simply achieved by enhanced permeation and retention effect while the later one by attachment of ligands on the surface of the lipid-based particulate system. Monocytes have many receptors e.g., mannose, scavenger, integrins, cluster of differentiation 14 (CD14) and cluster of differentiation 36 (CD36). The ligands used against these receptors are peptides, lectins, antibodies, glycolipids, and glycoproteins. This review encloses extensive introduction of monocytes as a suitable carrier system for drug delivery, the design of lipid-based carrier system, possible ways for delivery of therapeutics to monocytes, and the role of monocytes in the treatment of life compromising diseases such as cancer, inflammation, stroke, etc.

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Versatile Use of Nanosponge in the Pharmaceutical Arena: A Mini-Review

Recent Patents on Nanotechnology ◽

10.2174/1872210514999200901200558 ◽

2020 ◽

Vol 14 (4) ◽

pp. 351-359

Author(s):

Shubham Shrestha ◽

Sankha Bhattacharya

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Porous Structure ◽

Drug Delivery System ◽

Delivery System ◽

Dosage Form ◽

Carrier System ◽

Current Review ◽

Long Time ◽

Preparation Techniques

Drug delivery for a long time has been a major problem in the pharmaceutical field. The development of a new Nano-carrier system called nanosponge has shown the potential to solve the problem. Nanosponge has a porous structure and can entrap the drug in it. It can carry both hydrophilic and hydrophobic drugs. They also provide controlled release of the drugs and can also protect various substances from degradation. Nanosponge can increase the solubility of drugs and can also be formulated into an oral, topical and parenteral dosage form. The current review explores different preparation techniques, characterization parameters, as well as various applications of nanosponge. Various patents related to nanosponge drug delivery system have been discussed in this study.

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Practical low complexity frequency domain equalizer for IEEE802.16 single-carrier system

IET International Conference on Wireless Mobile and Multimedia Networks Proceedings (ICWMMN 2006) ◽

10.1049/cp:20061488 ◽

2006 ◽

Author(s):

Leilei Liu ◽

Wei Hong ◽

Hongxin Zhao ◽

Haiming Wang ◽

Yuanqing Wang

Keyword(s):

Frequency Domain ◽

Low Complexity ◽

Carrier System ◽

Single Carrier

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Modified Fluorescent PEG-Based Carrier System for In-vitro Imaging

IOP Conference Series Materials Science and Engineering ◽

10.1088/1757-899x/1091/1/012020 ◽

2021 ◽

Vol 1091 (1) ◽

pp. 012020

Author(s):

Aswathi Thomas ◽

Dr. Aravind Kumar Rengan

Keyword(s):

Carrier System

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735. Genetically Modified Stem Cells for the Treatment of Myocardial Infarction Using Novel Lysine-Based Nonviral Carrier System

Molecular Therapy ◽

10.1016/s1525-0016(16)37308-7 ◽

2011 ◽

Vol 19 ◽

pp. S281

Keyword(s):

Myocardial Infarction ◽

Stem Cells ◽

Genetically Modified ◽

Carrier System

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Improving the genistein oral bioavailability via its formulation into the metal–organic framework MIL-100(Fe)

Journal of Materials Chemistry B ◽

10.1039/d0tb02804e ◽

2021 ◽

Vol 9 (9) ◽

pp. 2233-2239

Author(s):

Adrià Botet-Carreras ◽

Cristina Tamames-Tabar ◽

Fabrice Salles ◽

Sara Rojas ◽

Edurne Imbuluzqueta ◽

...

Keyword(s):

Oral Bioavailability ◽

Metal Organic Framework ◽

Drug Carrier ◽

Aqueous Solubility ◽

Carrier System ◽

System P ◽

Metal Organic ◽

Drug Carrier System ◽

Organic Framework

Despite the interesting chemopreventive, antioxidant and antiangiogenic effects of the natural bioflavonoid genistein (GEN), its low aqueous solubility and bioavailability make it necessary to administer it using a suitable drug carrier system.

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