C‐reactive protein assessment to predict early septic complications after laparoscopic bowel resection for endometriosis: a diagnostic study

2019 ◽  
Vol 126 (9) ◽  
pp. 1176-1182 ◽  
Author(s):  
A Scattarelli ◽  
M Carriou ◽  
L Boulet ◽  
R Chati ◽  
J Coget ◽  
...  
Keyword(s):  
Bowel Resection ◽  
Diagnostic Study ◽  
C Reactive Protein ◽  
Septic Complications ◽  
Reactive Protein ◽  
Laparoscopic Bowel Resection

scholarly journals Kinetics of C-reactive protein, interleukin-6 and -10, and phospholipase A2-II in severely traumatized septic patients

2010 ◽  
Vol 67 (11) ◽  
pp. 893-897 ◽  
Author(s):  
Zeljko Lausevic ◽  
Goran Vukovic ◽  
Biljana Stojimirovic ◽  
Jasna Trbojevic-Stankovic ◽  
Vladimir Resanovic ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Injury Severity ◽  
C Reactive Protein ◽  
Surgical Intensive Care ◽  
Septic Complications ◽  
Mean Values ◽  
Protein Levels ◽  
Reactive Protein ◽  
Significant Difference ◽  
Kinetics Of

Background/Aim. Injury-induced anergy is one of the key factors contributing to trauma victims' high susceptibility to sepsis. This group of patients is mostly of young age and it is therefore essential to be able to predict as accurately as possible the development of septic complications, so appropriate treatment could be provided. The aim of this study was to assess kinetics of interleukin (IL) -6 and -10, phospholipase A2- II and C-reactive protein (CRP) in severely traumatized patients and explore the possibilities for early detection of potentially septic patients. Methods. This prospective study included 65 traumatized patients with injury severity score (ISS) > 18, requiring treatment at surgical intensive care units, divided into two groups: 24 patients without sepsis and 41 patients with sepsis. C-reactive protein, IL-6 and -10 and phospholipase A2 group II, were determined within the first 24 hours, and on the second, third and seventh day of hospitalization. Results. Mean values of IL-6 and phospholipase A2-II in the patients with and without sepsis did not show a statistically significant difference on any assessed time points. In the septic patients with ISS 29-35 and > 35 on the days two and seven a statistically significantly lower level of IL-10 was found, compared with those without sepsis and with the same ISS. C-reactive protein levels were significantly higher in septic patients with ISS 18-28 on the first day. On the second, third and seventh day CRP levels were significantly lower in the groups of septic patients with ISS 29-35 and > 35, than in those with the same ISS but without sepsis. Conclusion. Mean levels of CRP on the first day after the injury may be useful predictor of sepsis development in traumatized patients with ISS score 18-28. Mean levels of CRP on the days two, three and seven after the injury may be a useful predictor of sepsis development in traumatized patients with ISS score more than 28. Mean levels of IL-10 on the second and seventh day after the injury may be a useful predictor of sepsis development in traumatized patients with ISS score > 28.

scholarly journals C-reactive protein and procalcitonin - laboratory markers of degrees of severity and complications of an acute necrotic pancreatitis

2020 ◽  
Vol 87 (3-4) ◽  
pp. 14-17
Author(s):  
O. V. Rotar ◽  
I. V. Khomiak ◽  
V. I. Rotar ◽  
A. I. Khomiak ◽  
S. I. Railianu
Keyword(s):  
Septic Shock ◽  
Protein Concentration ◽  
Inflammatory Process ◽  
Clinical Laboratory ◽  
C Reactive Protein ◽  
Septic Complications ◽  
Reactive Protein ◽  
Laboratory Markers ◽  
Necrotic Pancreatitis ◽  
Degrees Of Severity

Objective. To conduct comparative estimation of efficacy of C-reactive protein and procalcitonin as laboratory markers for stratification of the patients severity state suffering an acute necrotic pancreatitis. Materials and methods. Prospective cohort investigation, including 151 patients with an acute necrotic pancreatitis, was conducted. Clinical, laboratory and bacteriological investigations were accomplished. The levels of C-reactive protein and procalcitonin were determined in the blood plasm. Results. The necrotic accumulations infectioning was diagnosed in 89 (58.9%) patients: local purulent complications - in 27, sepsis - in 33,septic shock - in 29. In 62 patients with sterile pancreonecrosis a C-reactive protein concentration have raised from (5.6 ± 0.89) to (206 ± 29) mg/l (p˂0.001). Development of purulent-septic complications was accompanied by significant and trustworthy (p<0.01) elevation of procalcitonin concentration: in the patients with sepsis - up to (5.05 ± 0.92) ng/ml, in the patients with septic shock - up to (7.25 ± 2.15) ng/ml. Conclusion. Simultaneous measurement of levels of C-reactive protein and procalcitonin in the blood plasm in patients, suffering acute necrotic pancreatitis, gives permission to determine the inflammatory process character and stratify the disease severity in its early terms.

scholarly journals A Promising New Predictive Factor for Detecting Bowel Resection in Childhood Intussusception: Lymphocyte-C Reactive Protein Ratio

2021 ◽  
Author(s):  
Bailin Chenilin Chen ◽  
Jian Cao ◽  
Chengwei Yan ◽  
Chao Zheng ◽  
Jingyu Chen ◽  
...  
Keyword(s):  
Receiver Operating Characteristic ◽  
Operating Characteristic ◽  
Bowel Resection ◽  
Intestinal Resection ◽  
Inflammatory Factors ◽  
C Reactive Protein ◽  
Intestinal Necrosis ◽  
Lymphocyte Ratio ◽  
Reactive Protein ◽  
Receiver Operating

Abstract Background: The most critical concern for management of childhood intussusception is the bowel resection due to the intestinal ischemia and necrocis. It is of great importance for early prediction of this problem. We investigate the value of various combinations of inflammatory factors to predict the intestinal necrocis and resection.Methods: We retrospectively reviewed the medical records of pediatric patients with intussusception, which undergone surgical management. During the research period, 47 patients undergone intestinal resection due to intestinal necrocis and 68 patients without intestinal resection were enrolled. We evaluated the diagnostic values of various combination of inflammatory markers from preoperative period laboratory analyses using the receiver operating characteristic (ROC) method.Results: In the current cohort, 115 patients were operated for intussusception, among them, 47 patients (40.9%) undergone intestinal resections. In patients with intestinal resections, neutrophil count(p=0.013), CRP(p=0.002), platelet–lymphocyte ratio(PLR, p=0.008), NLR(neutrophil–lymphocyte ratio, p=0.026), and LCR(lymphocyte–CRP ratio, p<0.001) values were significantly higher than those in the patients without any resections. Receiver operating characteristic (ROC) analysis results showed that the combination of lymphocytic count along with C-reactive protein levels (LCR) demonstrated the highest correlation with intestinal resection due to intussusception compared with other parameters in patients, with sensitivity of 0.82(0.73–0.86) and specifficity of 0.80(0.57–0.94) for the diagnosis of strangulation. Conclusion: The preoperative LCR level is a useful marker to predict the need for intestinal resection due to intestinal necrosis in patients with intussusception.

C-Reactive Protein as a Marker of Postoperative Septic Complications

2012 ◽  
Vol 84 (2) ◽  
Author(s):  
Andrzej Witczak ◽  
Piotr Jurałowicz ◽  
Bogdan Modzelewski ◽  
Małgorzata Gawlik
Keyword(s):  
C Reactive Protein ◽  
Septic Complications ◽  
Reactive Protein ◽  
Postoperative Septic Complications

Сlinical use of immune plasma in septic conditions

2020 ◽  
Vol 22 (3) ◽  
pp. 127-131
Author(s):  
L. A. Skripay ◽  
V. N. Vilyaninov ◽  
N. V. Belgesov
Keyword(s):  
Antibiotic Therapy ◽  
Total Protein ◽  
Fresh Frozen Plasma ◽  
C Reactive Protein ◽  
Average Volume ◽  
Septic Complications ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation ◽  
Fresh Frozen ◽  
Frozen Plasma

Abstract. The effectiveness of clinical use of immune plasma in comparison with conventional fresh-frozen plasma in septic conditions is considered. It was found that the use of immune plasma in the treatment of patients suffering from septic complications, against the background of antibiotic therapy, is more effective than the use of conventional freshly frozen plasma. In patients who received immune plasma transfusions, there was a significant decrease in the inflammatory response of the blood (decrease in leukocytosis, erythrocyte sedimentation rate, C-reactive protein), and the level of procalcitonin also decreased. The level of total protein, on the contrary, increased after each transfusion of this component. In patients who received fresh frozen plasma transfusion, there were no positive changes in the indicators of inflammatory blood reaction (the number of white blood cells and the rate of erythrocyte sedimentation after each transfusion increased, changes in C-reactive protein were insignificant). The level of procalcitonin and total protein increased after each infusion. In all patients who were transfused blood components, against the background of antibiotic therapy, the result of treatment was also influenced by the number of microorganisms seeded from the wound surface during primary bacteriological seeding. In General, in septic conditions, transfusion of immune plasma was more effective than transfusion of freshly frozen plasma. This effect on normalization of laboratory blood parameters was observed with a smaller average volume of transfused immune plasma (0,58 l) compared to a larger average volume (0,83 l) of transfused freshly frozen plasma.

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