Weekly split‐dose regimen for oral methotrexate reduced polyglutamation in red blood cells in patients with rheumatoid arthritis compared with single‐dose regimen: Results from a multicentered randomized control trial

2020 ◽  
Vol 23 (10) ◽  
pp. 1328-1336
Author(s):  
Shouhei Nagaoka ◽  
Kou Katayama ◽  
Tsuyoshi Kasama ◽  
Masao Sato ◽  
Shigeru Ohno ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Single Dose ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Dose Regimen ◽  
Randomized Control Trial ◽  
Oral Methotrexate ◽  
Split Dose ◽  
Randomized Control

scholarly journals Efficacy of Single Pre-Operative Dose of Glucocorticoid (125mg of Solumedrol Intravenous) in Terms of Seroma Formation in Patients Undergoing Mastectomy with Axillary Clearance For Breast Cancer: A Randomized Control Trial

2020 ◽  
pp. 1-5
Author(s):  
Aliya Ishaq ◽  
Abida Parveen ◽  
Aliya Ishaq ◽  
Mariya Ishaq ◽  
Muhammad Jamshaid Hussain Khan ◽  
...  
Keyword(s):  
Single Dose ◽  
Randomized Control Trial ◽  
Removal Rate ◽  
Fluid Collection ◽  
Study Groups ◽  
Seroma Formation ◽  
Control Group ◽  
Drain Removal ◽  
Randomized Control ◽  
And Control

Objective: The study aimed to determine the efficacy of single dose of glucocorticoid (125 mg of Solumedrol intravenous) in terms of seroma formation after mastectomy in patient with carcinoma of breast. Study Design: Randomized control trial. Place and Duration of Study: Study was conducted in the Department of General Surgery, Liaquat National Hospital Karachi, Pakistan from july 1 to dec 31, 2010. Patients and Methods: Patients were randomly divided in two groups (study and control) each group consisting of 30 patients. Randomization was done by opening of a sealed envelope which had a slip bearing the name of study medication (solumederol or saline as placebo) to be administered. The study group received a single dose of inj 125mg solumedrol IV half an hour prior to surgery by resident scrub in surgery. A similar procedure was applied to the control group and patients in controlled group were administered an equal volume of saline intravenously. After drain removal patients in both groups were observed for a duration of 2 weeks for sermoa formation. Detection of seroma formation was based on clinical grounds by absence of any fluid collection at mastectomy bed as detected by manual palpation. SPSS 10 was used for analysis. Results: Seroma formation was observed in 66.7% (40/60) women 2 weeks post drain removal. Rate of seroma formation was significantly low in study groups than control groups (33.3% vs. 100%; p=0.0001). Conclusion: Single dose of steroid is efficacious in reducing the post mastectomy seroma formation.

scholarly journals Glucocorticoid-Responsive Cold Agglutinin Disease in a Patient with Rheumatoid Arthritis

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Kyoko Honne ◽  
Takao Nagashima ◽  
Masahiro Iwamoto ◽  
Toyomi Kamesaki ◽  
Seiji Minota
Keyword(s):  
Rheumatoid Arthritis ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Bovine Serum ◽  
Cold Agglutinin ◽  
Cold Agglutinin Disease ◽  
Cold Agglutinins ◽  
Thermal Amplitude

A 57-year-old man with rheumatoid arthritis developed severe anemia during treatment with adalimumab plus methotrexate. Cold agglutinin disease was diagnosed because haptoglobin was undetectable, cold agglutinin was positive (1 : 2048), and the direct Coombs test was positive (only to complement). Although the cold agglutinin titer was normalized (1 : 64) after treatment with prednisolone (0.7 mg/kg/day for two weeks), the patient’s hemoglobin did not increase above 8 g/dL. When cold agglutinins were reexamined using red blood cells suspended in bovine serum albumin, the titer was still positive at 1 : 1024. Furthermore, the cold agglutinin had a wide thermal amplitude, since the titer was 1 : 16 at 30°C and 1 : 1 at 37°C. This suggested that the cold agglutinin would show pathogenicity even at body temperature. After the dose of prednisolone was increased to 1 mg/kg/day, the patient’s hemoglobin rapidly returned to the normal range. The thermal amplitude test using red blood cells suspended in bovine serum albumin is more sensitive than the standard test for detecting pathogenic cold agglutinins.

scholarly journals Comparative evaluation of pre-treatment medication on post-instrumentation pain: Randomized control trial.

2020 ◽  
Vol 6 (2) ◽  
pp. 22-27
Author(s):  
Atul Jain ◽  
Chahat Chabra ◽  
Abinay Agarwal ◽  
Rohit Sharma ◽  
Faisal Khan ◽  
...  
Keyword(s):  
Single Dose ◽  
Lower Incidence ◽  
Randomized Control Trial ◽  
Comparative Evaluation ◽  
Endodontic Treatment ◽  
Rotary Instruments ◽  
Randomized Control ◽  
Pre Treatment ◽  
Treatment Medication

Aims and Objectives: To comparatively evaluate, the effect of preoperative single dose, of paracetamol and ibuprofen on PIP, using two different rotary instruments. Materials and Methods: 60 patients were randomly premedicated, with either paracetamol or ibuprofen and canal was instrumented, with either Hyflex or Protaper Gold files. PIP was evaluated at 6, 12, 24, 48 and 72 hrs. Results: Lower incidence and intensity of PIP, occurred in patients, premedicated with Ibuprofen and where canal was instrumented with Hyflex. Conclusion: Use of Ibuprofen, as a premedication during endodontic treatment, with Hyflex rotary instruments, decreases PIP.

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