scholarly journals Colorectal cancer‐related pulmonary metastasectomy: Factors affecting survival time

2021 ◽  
Author(s):  
Norman R. Williams ◽  
Fergus Macbeth ◽  
Tom Treasure
2017 ◽  
Vol 9 (S12) ◽  
pp. S1282-S1290 ◽  
Author(s):  
Luca Ampollini ◽  
Letizia Gnetti ◽  
Matteo Goldoni ◽  
Lorenzo Viani ◽  
Elisabetta Faedda ◽  
...  

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Guodong Li ◽  
Jiangang Liu

Colorectal cancer (CRC) is one of the most common malignant tumors with high morbidity and mortality. The early symptoms are latent, and most patients are in the middle or late stage when they are diagnosed. The best opportunity for surgery has been lost, and surgical resection has failed to achieve good results. In clinical practice, targeted therapy or chemotherapy is usually the main treatment. The mFOLFOX6 regimen is a standardized regimen for the treatment of advanced CRC. The main drugs in this regimen are oxaliplatin and 5-fluorouracil (5-FU). Patients with advanced CRC combined with standard chemotherapy regimens can achieve a higher resection rate of liver metastases in unresectable patients, which can achieve significant survival improvement. Therefore, in this study, oxaliplatin + calcium folinate + 5-Fu + mFOLFOX6 regimen was combined with cetuximab and simvastatin to treat CRC patients, and the clinical efficacy and prognosis were analyzed, as well as the prognostic factors. The results showed that the addition of simvastatin on the basis of conventional mFOLFOX6 regimen combined with cetuximab chemotherapy could effectively improve the efficacy, reduce the total incidence of adverse reactions, improve the overall survival rate, and prolong the overall survival time of patients. Pathological grade and peritoneal metastasis were the factors affecting the mean survival time of CRC patients.


1986 ◽  
Vol 144 (12) ◽  
pp. 621-623 ◽  
Author(s):  
Finlay A. Macrae ◽  
D. James B. St. John ◽  
Arunasalam Ambikapathy ◽  
Ken Sharpe ◽  
John F. Garner ◽  
...  

2012 ◽  
Vol 143 (1) ◽  
pp. 51-54.e4 ◽  
Author(s):  
Amanda I. Phipps ◽  
Polly A. Newcomb ◽  
Xabier Garcia–Albeniz ◽  
Carolyn M. Hutter ◽  
Emily White ◽  
...  

2015 ◽  
Vol 11 (2s) ◽  
pp. 15-18 ◽  
Author(s):  
Marcello Migliore ◽  
Mišel Milošević ◽  
Belinda Lees ◽  
Tom Treasure ◽  
Giuseppe Di Maria

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hyo Seon Ryu ◽  
Seok-Byung Lim ◽  
Eu-Tteum Choi ◽  
Inho Song ◽  
Jong Lyul Lee ◽  
...  

AbstractWe aimed to evaluate the clinical feasibility of a new visual grading system. We included 50 patients who underwent resection of primary colorectal cancer. Before anastomosis, the marginal vessel was cut and the perfusion status was assessed by a visual grading system. The visual grading system is comprised of five grades according to the bleeding from the marginal vessel and is categorized into 4 groups: good (grade A and B), moderate (grade C), poor (grade D) and none (grade E). Colorectal anastomosis was performed only in the good and moderate groups. We compared postoperative outcomes between the good and moderate groups and analysed the factors affecting the perfusion grade. Among the patients, 48% were grade A, 12% were grade B, and 40% were grade C. There was no anastomotic leakage. Only one patient with grade C showed ischemic colitis and needed reoperation. Age was the only factor correlated with perfusion grade in multivariate analysis (OR 1.080, 95% CI 1.006–1.159, p = 0.034). The perfusion grades were significantly different between > 65 and < 65 year-old patients (> 65, A 29.2% B 12.5% C 58.3% vs. < 65, A 65.4% B 11.5% C 23.1%, p = 0.006). Our intraoperative perfusion assessment that uses a cutting method and a visual grading system is simple and useful for performing a safe anastomosis after colorectal resection. If the perfusion grade is better than grade C, an anastomosis can be performed safely. Age was found to be an important factor affecting the perfusion grade.


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