scholarly journals Intraoperative perfusion assessment of the proximal colon by a visual grading system for safe anastomosis after resection in left-sided colorectal cancer patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hyo Seon Ryu ◽  
Seok-Byung Lim ◽  
Eu-Tteum Choi ◽  
Inho Song ◽  
Jong Lyul Lee ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colorectal Anastomosis ◽  
Proximal Colon ◽  
Grading System ◽  
Visual Grading ◽  
Old Patients ◽  
Factors Affecting ◽  
Poor Grade ◽  
Perfusion Assessment ◽  
Colorectal Cancer Patients

AbstractWe aimed to evaluate the clinical feasibility of a new visual grading system. We included 50 patients who underwent resection of primary colorectal cancer. Before anastomosis, the marginal vessel was cut and the perfusion status was assessed by a visual grading system. The visual grading system is comprised of five grades according to the bleeding from the marginal vessel and is categorized into 4 groups: good (grade A and B), moderate (grade C), poor (grade D) and none (grade E). Colorectal anastomosis was performed only in the good and moderate groups. We compared postoperative outcomes between the good and moderate groups and analysed the factors affecting the perfusion grade. Among the patients, 48% were grade A, 12% were grade B, and 40% were grade C. There was no anastomotic leakage. Only one patient with grade C showed ischemic colitis and needed reoperation. Age was the only factor correlated with perfusion grade in multivariate analysis (OR 1.080, 95% CI 1.006–1.159, p = 0.034). The perfusion grades were significantly different between > 65 and < 65 year-old patients (> 65, A 29.2% B 12.5% C 58.3% vs. < 65, A 65.4% B 11.5% C 23.1%, p = 0.006). Our intraoperative perfusion assessment that uses a cutting method and a visual grading system is simple and useful for performing a safe anastomosis after colorectal resection. If the perfusion grade is better than grade C, an anastomosis can be performed safely. Age was found to be an important factor affecting the perfusion grade.

scholarly journals Trends and Clinical Outcomes in Young-onset Colorectal Cancer Patients

2020 ◽  
Vol 49 (11) ◽  
pp. 848-856 ◽  
Author(s):  
Serene SN Goh ◽  
Edith XL Loo ◽  
Daniel JK Lee
Keyword(s):  
Colorectal Cancer ◽  
Emergency Surgery ◽  
Elective Surgery ◽  
Stage Iv ◽  
Tertiary Hospital ◽  
Signet Ring Cell ◽  
Factors Affecting ◽  
Young Onset ◽  
Signet Ring ◽  
Colorectal Cancer Patients

Introduction: Young individuals with colorectal cancer (CRC) tend to be diagnosed at advanced stages and are not routinely included in screening programmes. This study describes the incidence, disease pattern and factors affecting overall survival in young- onset CRC. Methods: A retrospective study of young-onset CRC patients diagnosed between 2010 and 2017 in a tertiary hospital was conducted. Results: There were 99 patients, 69.7% had left-sided while 30.3% had right-sided CRC. The mean age was 43.3 years (43.3±5.0) and 62 patients (62.6%) were male. The incidence of young-onset CRC has been on the rise since 2014. Out of 99 patients, 65 (65.7%) underwent elective surgery, 30 (30.3%) underwent emergency surgery and the remainder 5 (4.0%) were palliated. The most common presenting complaints for patients who underwent elective surgery were abdominal pain, per-rectal bleeding and altered bowel habits. For patients who required emergency surgery, 20 (66.6%) presented with intestinal obstruction and 10 (33.3%) had intestinal perforation. There were 42 (42.4%) stage III CRC and 20 (20.2%) stage IV CRC. The most frequent metastatic site was the liver (20/20, 100%). Five patients had signet ring cells (5.1%) in their histology while 15 (15.2%) had mucinous features. The overall 5-year survival of young-onset CRC was 82.0%. Advanced overall stage (hazard ratio (HR) 6.1, CI 1.03–3.62) and signet ring histology (HR 34.2, CI 2.24–5.23) were associated with poor prognosis. Conclusion: Young-onset CRC tend to be left-sided with advanced presentations. However, their 5-year survival remains favourable as compared to the general population. Keywords: Colorectal screening in the young, early-onset colorectal cancer, signet ring cell colorectal cancer

scholarly journals Factors Affecting Prognosis in Metastatic Colorectal Cancer Patients

2015 ◽  
Vol 16 (7) ◽  
pp. 3015-3021 ◽  
Author(s):  
Baki Eker ◽  
Ersin Ozaslan ◽  
Halit Karaca ◽  
Veli Berk ◽  
Oktay Bozkurt ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Cancer Patients ◽  
Factors Affecting ◽  
Colorectal Cancer Patients

scholarly journals Factors Affecting Survival Trend in Colorectal Cancer- A Hospital Based Study

2019 ◽  
Vol 31 (2) ◽  
pp. 12-16
Author(s):  
Md Khalequzzaman Sarker ◽  
Md Moniruzzaman Sarker ◽  
Nasrin Ara Parveen ◽  
Anisur Rahman ◽  
Mohammad Sofiul Kadir ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colorectal Carcinoma ◽  
Cancer Patients ◽  
Median Survival ◽  
Palliative Treatment ◽  
Curative Treatment ◽  
Age Group ◽  
Factors Affecting ◽  
Colorectal Cancer Patients ◽  
Common Malignancy

Colorectal carcinoma is the second most common malignancy and the second leading cause of cancer deaths in Western countries. The condition becomes increasingly common over the age of 50 years. The total number of colorectal cancer patients available for the study within the stipulated time was 56. Among them 64.29% patients were male and 35.71% patients were female. 01.79% patient belonged to age group ≤ 20, 12.5% belonged to age group 21-30, 19.64% belonged to age group 31-40, 25.0% belonged to age group 41-50, 26.79% belonged to age group 51-60, 08.93% belonged to age group 61-70 and 05.35% patients were >70 years of age. Mean age was 48.05 years ± 13.97 SD. In our study, 27.2% survived ≤3 months, 36.4% 4-6 months, 09.1% 7-9 months, 18.2% 10-12 months, 09.1% 13-24 months and 0% >24 months. Among 11 expired patients, 03 got curative treatment and rest of 08 got palliative treatment. Those who got curative treatment, 66.7% survived 10-12 months and 33.3% 13-24 months. Those who got palliative treatment 37.5% survived ≤3 months, 50.0% 4-6 months and 12.5% 7-9 months. Overall median survival was 07 months, for curative treatment 15 months and for palliative treatment 05 months. TAJ 2018; 31(2): 12-16

scholarly journals Preoperative C-reactive protein as a prognostic factor in stage IV colorectal cancer

2021 ◽  
Author(s):  
Hiroka Kondo ◽  
Yasumitsu Hirano ◽  
Toshimasa Ishii ◽  
Shintaro Ishikawa ◽  
Takatsugu Fujii ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Survival Rate ◽  
Stage Iv ◽  
Time Frame ◽  
Long Term Results ◽  
Factors Affecting ◽  
Lower Survival Rate ◽  
Reactive Protein ◽  
Stage Iv Colorectal Cancer ◽  
Colorectal Cancer Patients

Background A prognosis for stage IV colorectal cancer is generally poor. As a result, the development of an appropriate treatment strategy for each individual with this disease within a limited time frame is important. Few studies have been made of CRP in stage IV cases of colorectal cancer so it is unclear whether CRP is a useful prognostic marker for this disease. Thus, the purpose of this study was to clarify the relationship between the preoperative CRP level and the prognosis of stage IV colorectal cancer. Patients and methods Between April 2007 and December 2015, 384 patients with stage IV colorectal cancer who underwent primary resection were included. Patients were divided into high (HCG) and low (LCG) CRP groups based on a preoperative CRP cut-off value of ≥1.0 mg/dL. Postoperative short- and long-term results were examined retrospectively. Results The 5-year survival rate was 24.6% for HCG and 36.7% for LCG, indicating the survival rate for HCG was lower. The study was limited to patients who were unable to undergo R0 surgery. Preoperative CEA levels were higher in HCG while the postoperative chemotherapy induction rate was lower. HCG also showed a significantly lower survival rate than LCG. Multivariate analysis showed that CRP levels above 1.0 mg/dL, poorly differentiated histopathology, and the absence of chemotherapy were risk factors affecting overall survival. Conclusion These results suggest that the preoperative CRP level may be a useful biomarker for the prognosis of incurable stage IV colorectal cancer.

Looking at Differences in Stage and Treatment of Colorectal Cancers across Italy: A EUROCARE-5 High Resolution Study

2012 ◽  
Vol 98 (6) ◽  
pp. 671-677 ◽  
Author(s):  
Pamela Minicozzi ◽  
Adele Caldarella ◽  
Adriano Giacomin ◽  
Maurizio Ponz de Leon ◽  
Rosaria Cesaraccio ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Relative Survival ◽  
Cancer Registries ◽  
Northern Italy ◽  
Italian Population ◽  
Odds Ratios ◽  
Old Patients ◽  
Colorectal Cancer Patients

Aims and background The high incidence and the estimate of a five-year relative survival of 59% for colorectal cancer in Italy were the main reasons to investigate the management of Italian patients with colorectal cancer diagnosed in the early 2000s. Methods Samples of adult (≥15 years) patients diagnosed in 2003–2005 with a colorectal cancer were randomly selected in 8 Italian population-based cancer registries. The z test was used to evaluate differences in proportions of Dukes stage, patients with at least 12 examined lymph nodes, and of cases treated with curative surgery plus chemotherapy or plus radiotherapy and diagnosed with colon or rectal tumors, respectively. Logistic regression models were used to estimate odds ratios of receiving the selected treatment in each cancer registry, age group and stage category, by anatomical subsite. Results A total of 3,938 colorectal cancer patients were analyzed. About 40% of the cases were over 75 years of age at diagnosis and at Dukes A + B stages. Higher proportions of early stages were found in the northern cancer registries. High percentages of resection with a curative intent were observed in Reggio Emilia (northern Italy), in 15 to 74-year-old patients, and at Dukes B stage. At least 12 lymph nodes were more frequently examined in the north of the country. After adjusting for age and stage, no significant differences were seen in the odds ratios of receiving surgery plus chemotherapy between cancer registries, whereas surgery plus radiotherapy was more frequent in Napoli (southern Italy) and less frequent in Biella (northern Italy). Conclusions Some disparities in staging and treatment of colorectal cancer patients persist across Italy. National oncological plans still need to reduce inequalities in provision and access to proper care.

Factors Affecting Cancer Prevention Behaviors and Cancer Screening in First-Degree Relatives of Breast and Colorectal Cancer Patients in Korea: A Cross-Sectional Study

2021 ◽  
pp. RTNP-D-20-00113
Author(s):  
Yoonjung Lee ◽  
Kyunghwa Lee ◽  
Sanghee Kim
Keyword(s):  
Colorectal Cancer ◽  
Cancer Screening ◽  
Cancer Risk ◽  
Cancer Prevention ◽  
Cancer Patients ◽  
Cancer Worry ◽  
Cancer Knowledge ◽  
Cross Sectional ◽  
Factors Affecting ◽  
Colorectal Cancer Patients

BackgroundFirst-degree relatives (FDRs) of cancer patients have a high risk of cancer due to a similar lifestyle and genetic predisposition. However, previous studies rarely examined the level of cancer prevention behaviors and screening and affecting factors in cancer patients’ FDRs.PurposeThis study aimed to describe the levels of cancer knowledge, attitudes toward cancer, cancer worry, perceived cancer risk, and cancer prevention behaviors and cancer screening in FDRs of breast and colorectal cancer patients. Moreover, it sought to identify factors affecting cancer prevention behavior and cancer screening.MethodsA cross-sectional, descriptive correlational design was used. The study enrolled 138 FDRs of breast and colorectal cancer patients. Participants completed self-administered questionnaires at a tertiary hospital in Seoul, Korea. Descriptive statistics, frequencies, chi-square test, independent t test, one-way analysis of variance (ANOVA), Pearson’s correlation, multiple regression, and logistic regression were performed for data analysis.ResultsThe levels of perceived cancer risk, cancer knowledge, attitude toward cancer, and cancer prevention behaviors were moderate, while the level of cancer worry was high. Ninety-two participants reported having undergone cancer screenings, but the types of screening were not associated with their family history. Age, gender, and attitude toward cancer affected cancer prevention behaviors. The cancer screening rate was higher in older participants, in women, and in patients’ FDRs with a longer cancer diagnosis.Implications for PracticeAttitude was the modifiable factor for cancer prevention behaviors. Nurse-led educational and counseling interventions should be developed to improve attitude toward cancer among FDRs of cancer patients.

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