scholarly journals Dietary fat composition influences glomerular and proximal convoluted tubule cell structure and autophagic processes in kidneys from calorie-restricted mice

Aging Cell ◽  
2016 ◽  
Vol 15 (3) ◽  
pp. 477-487 ◽  
Author(s):  
Miguel Calvo-Rubio ◽  
Mª Isabel Burón ◽  
Guillermo López-Lluch ◽  
Plácido Navas ◽  
Rafael de Cabo ◽  
...  
Metabolism ◽  
2016 ◽  
Vol 65 (7) ◽  
pp. 987-997 ◽  
Author(s):  
Hong Wang ◽  
Matthew D. Taussig ◽  
Nicholas V. DiPatrizio ◽  
Kimberley Bruce ◽  
Daniele Piomelli ◽  
...  

2019 ◽  
Vol 78 (02) ◽  
pp. 234-245 ◽  
Author(s):  
Yvonne M. Lenighan ◽  
Breige A. McNulty ◽  
Helen M. Roche

SFA intakes have decreased in recent years, both in Ireland and across other European countries; however a large proportion of the population are still not meeting the SFA recommendation of <10% of total energy (TE). High SFA intakes have been associated with increased CVD and type-2 diabetes (T2D) risk, due to alterations in cholesterol homoeostasis and adipose tissue inflammation. PUFA, in particular EPA and DHA, have been associated with health benefits, including anti-inflammatory effects. It is well established that dietary fat composition plays an important role in biological processes. A recent review of evidence suggests that replacement of SFA with PUFA has potential to reduce risk of CVD and T2D. The public health and molecular impact of EPA and DHA have been well-characterised, while less is known of effects of α-linolenic acid (ALA). The current dietary guideline for ALA is 0·5% TE; however evidence from supplementation trials suggests that benefit is observed at levels greater than 2 g/d (0·6–1% TE). This review highlights the gap in the evidence base relating to effects of the replacement of SFA with ALA, identifying the need for randomised controlled trials to determine the optimal dose of ALA substitution to define the efficacy of dietary fat modification with ALA.


2002 ◽  
Vol 76 (6) ◽  
pp. 1222-1229 ◽  
Author(s):  
Agneta Andersson ◽  
Cecilia Nälsén ◽  
Siv Tengblad ◽  
Bengt Vessby

1972 ◽  
Vol 49 (7) ◽  
pp. 395-402 ◽  
Author(s):  
Roslyn B. Alfin-Slater ◽  
Yaichiro Shimma ◽  
Herbert Hansen ◽  
Penelope Wells ◽  
Lilla Aftergood ◽  
...  

2006 ◽  
Vol 38 (Supplement) ◽  
pp. S483
Author(s):  
Chihoko Ueda ◽  
Stephen F. Burns ◽  
Masashi Miyashita ◽  
David J. Stensel ◽  
Ron Maughan

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