A modular and reusable model of epithelial transport in the proximal convoluted tubule

We review a collection of published renal epithelial transport models, from which we build a consistent and reusable mathematical model able to reproduce many observations and predictions from the literature. The flexible modular model we present here can be adapted to specific configurations of epithelial transport, and in this work we focus on transport in the proximal convoluted tubule of the renal nephron. Our mathematical model of the epithelial proximal convoluted tubule describes the cellular and subcellular mechanisms of the transporters, intracellular buffering, solute fluxes, and other processes. We provide free and open access to the Python implementation to ensure our multiscale proximal tubule model is accessible; enabling the reader to explore the model through setting their own simulations, reproducibility tests, and sensitivity analyses.

The Kidney

This chapter puts forward a series of experiments in which scientists bioprinted one of the critical components of a kidney’s nephron (the filtering unit of the kidney), namely the proximal convoluted tubule where the majority of nutrient absorption back into the bloodstream takes place (and where most drug-induced toxicities of the kidney occur). The same team of researchers bioprinted colocalized (printed very close together) proximal tubules and blood vessels and, with the use of fluorescence microscopy, were able to observe vectorial transport, the process in which valuable nutrients such as serum albumin are selectively reabsorbed into the bloodstream. They also induced a state of hyperglycemia and administered a countermeasure drug, thus demonstrating the ability of their bioprinted kidney tissue to functionally respond as native kidney tissue does to an overdose of glucose and to a drug designed to mitigate this undesirable condition.

Idiopathic Adult Onset Fanconi’s Syndrome in a Patient Treated with Oxaliplatin

Proximal tubular injury is known complication of chemotherapy such as carboplatin. However, there are far more other causes of injury and in many situations, the etiology is difficult to elucidate. Here we describe a case of a patient who presented with a urine analysis consistent of Fanconi’s syndrome with signs and symptoms of the disorder prior to chemotherapy but requiring admission for aggressive electrolyte replacement soon after the chemotherapy was completed. We further discuss causes of Fanconi’s syndrome and the importance of evaluation of the proximal convoluted tubule prior to administration of chemotherapy.

Histological Structure of the Varanus Salvator Kidney

Varanus salvator is known as the monitor lizard. This animal is a subspecies of endemic Indonesian monitor lizards which is only found in Java, Bali and Nusa Tenggara (except Timor Island). This study aims to determine the histological structure of the monitor lizard (Varanus salvator). The research was carried out for two months starting from September 2019 to October 2019 at the Animal Physics Laboratory and Zoology of UIN Sunan Kalijaga. The method used is the paraffin method. The results of the study were analyzed in a comparative descriptive manner by observation through a microscope and then taken using a camera. Based on the results of studies lizards (Varanus salvator) have distal convoluted tubule, proximal convoluted tubule, glomerulus, medullary ray and bowman’s capsule.