Long‐term alcohol drinking in High Drinking in the Dark mice is stable for many months and does not show alcohol deprivation effects

2021 ◽  
Author(s):  
John C. Crabbe ◽  
Wyatt R. Hack ◽  
Angela R. Ozburn ◽  
Antonia M. Savarese ◽  
Pamela Metten
Keyword(s):  
Alcohol Drinking ◽  
Drinking In The Dark

scholarly journals Ethanol Induces Long-Term Facilitation of NR2B-NMDA Receptor Activity in the Dorsal Striatum: Implications for Alcohol Drinking Behavior

2007 ◽  
Vol 27 (13) ◽  
pp. 3593-3602 ◽  
Author(s):  
J. Wang ◽  
S. Carnicella ◽  
K. Phamluong ◽  
J. Jeanblanc ◽  
J. A. Ronesi ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Alcohol Drinking ◽  
Drinking Behavior ◽  
Dorsal Striatum ◽  
Receptor Activity ◽  
Long Term Facilitation

Studies on a model of long term alcohol drinking

2001 ◽  
Vol 123 (2) ◽  
pp. 193-200 ◽  
Author(s):  
Jonathon D.S Holt ◽  
William P Watson ◽  
Hilary J Little
Keyword(s):  
Alcohol Drinking

scholarly journals Effects of Long-Term Alcohol Drinking on the Dopamine D2 Receptor: Gene Expression and Heteroreceptor Complexes in the Striatum in Rats

2018 ◽  
Vol 42 (2) ◽  
pp. 338-351 ◽  
Author(s):  
Kristin Feltmann ◽  
Dasiel Oscar Borroto-Escuela ◽  
Joëlle Rüegg ◽  
Luca Pinton ◽  
Thatiane de Oliveira Sergio ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alcohol Drinking ◽  
Dopamine D2 Receptor ◽  
Receptor Gene ◽  
D2 Receptor ◽  
Heteroreceptor Complexes ◽  
Dopamine D2 ◽  
Receptor Gene Expression

scholarly journals Female mice are more prone to develop an addictive-like phenotype for sugar consumption

2020 ◽  
Author(s):  
Shoupeng Wei ◽  
Sarah Hertle ◽  
Rainer Spanagel ◽  
Ainhoa Bilbao
Keyword(s):  
Drugs Of Abuse ◽  
Phase Iii ◽  
Sugar Consumption ◽  
Self Administration ◽  
Male And Female ◽  
Female Mice ◽  
Deprivation Effect ◽  
Sugar Addiction ◽  
Drinking In The Dark

AbstractBackgroundThe concept of “sugar addiction” is gaining increasing attention in both the lay media and scientific literature. However, the concept of sugar addiction is controversial and only a few studies have attempted to determine the “addictive” properties of sugar using rigorous scientific criteria.ObjectiveHere we set out to systematically test the addictive properties of sugar in male and female mice using established paradigms and models from the drug addiction field.MethodsMale and female C57BL/6N (8-10 weeks old) were evaluated in 4 experimental procedures to study the addictive properties of sugar: (i) a drinking in the dark (DID) procedure to model sugar binging; (ii) a long-term free choice home cage drinking procedure measuring the sugar deprivation effect (SDE) following an abstinence phase; (iii) a long-term operant sugar self-administration with persistence, motivation and compulsivity measures and (iv) intracranial self-administration (ICSS).ResultsFemale mice were more vulnerable to the addictive properties of sugar than male mice, showing higher binge and long-term, excessive drinking, a more pronounced relapse-like drinking following deprivation, and higher persistence and motivation for sugar. No sex differences were seen in a compulsivity test or reward sensitivity measured using ICSS following extended sugar consumption.ConclusionThis study demonstrates the occurrence of an addictive-like phenotype for sugar in male and female mice, similar to drugs of abuse, and suggests sex-dependent differences in the development of sugar addiction.

scholarly journals Long-term epigenetic changes in offspring mice exposed to alcohol during gestation and lactation

2019 ◽  
Vol 33 (12) ◽  
pp. 1562-1572 ◽  
Author(s):  
Lídia Cantacorps ◽  
Silvia Alfonso-Loeches ◽  
Consuelo Guerri ◽  
Olga Valverde
Keyword(s):  
Prefrontal Cortex ◽  
Alcohol Drinking ◽  
Alcohol Exposure ◽  
Learning Task ◽  
Spectrum Disorder ◽  
Epigenetic Changes ◽  
Histone H4 ◽  
Spectrum Disorders ◽  
Foetal Alcohol Spectrum Disorders

Background: Alcohol exposure impairs brain development and leads to a range of behavioural and cognitive dysfunctions, termed as foetal alcohol spectrum disorders. Although different mechanisms have been proposed to participate in foetal alcohol spectrum disorders, the molecular insights of such effects are still uncertain. Using a mouse model of foetal alcohol spectrum disorder, we have previously shown that maternal binge-like alcohol drinking causes persistent effects on motor, cognitive and emotional-related behaviours associated with neuroimmune dysfunctions. Aims: In this study, we sought to evaluate whether the long-term behavioural alterations found in offspring with early exposure to alcohol are associated with epigenetic changes in the hippocampus and prefrontal cortex. Methods: Pregnant C57BL/6 female mice underwent a model procedure for binge alcohol drinking throughout both the gestation and lactation periods. Subsequently, adult offspring were assessed for their cognitive function in a reversal learning task and brain areas were extracted for epigenetic analyses. Results: The results demonstrated that early binge alcohol exposure induces long-term behavioural effects along with alterations in histone acetylation (histone H4 lysine 5 and histone H4 lysine 12) in the hippocampus and prefrontal cortex. The epigenetic effects were linked with an imbalance in histone acetyltransferase activity that was found to be increased in the prefrontal cortex of mice exposed to alcohol. Conclusions: In conclusion, our results reveal that maternal binge-like alcohol consumption induces persistent epigenetic modifications, effects that might be associated with the long-term cognitive and behavioural impairments observed in foetal alcohol spectrum disorder models.

Long-term changes of salivary exoglycosidases and their applicability as chronic alcohol-drinking and dependence markers

2017 ◽  
Vol 20 (1) ◽  
pp. 64-75 ◽  
Author(s):  
Napoleon Waszkiewicz ◽  
Ewa Maria Kratz ◽  
Sylwia Chojnowska ◽  
Anna Zalewska ◽  
Krzysztof Zwierz ◽  
...  
Keyword(s):  
Alcohol Drinking ◽  
Chronic Alcohol ◽  
Long Term Changes

Scleroma of the Larynx and Associated Squamous Cell Carcinoma: A Causal Relationship?

2000 ◽  
Vol 109 (3) ◽  
pp. 306-310
Author(s):  
Kamal A. Abou El-Hamd
Keyword(s):  
Risk Factors ◽  
Air Pollution ◽  
Squamous Cell Carcinoma ◽  
Risk Factor ◽  
Alcohol Drinking ◽  
Laryngeal Carcinoma ◽  
English Language ◽  
Previous Irradiation ◽  
Language Literature

The known risk factors for development of laryngeal carcinoma are smoking, alcohol drinking, air pollution, laryngeal keratosis, single adult papillomas, and previous irradiation. Laryngeal scleroma as a risk factor for the development of laryngeal carcinoma has not been mentioned in the English-language literature, to my knowledge. This is a report of 2 cases of proven long-term rhinolaryngoscleroma that have changed to laryngeal carcinoma.

Withdrawal Symptoms in a Long-Term Model of Voluntary Alcohol Drinking in Wistar Rats

2000 ◽  
Vol 66 (1) ◽  
pp. 143-151 ◽  
Author(s):  
Sabine M Hölter ◽  
Astrid C.E Linthorst ◽  
Johannes M.H.M Reul ◽  
Rainer Spanagel
Keyword(s):  
Alcohol Drinking ◽  
Wistar Rats ◽  
Withdrawal Symptoms ◽  
Term Model

scholarly journals Synaptic and Morphological Neuroadaptations in the Putamen Associated with Long-Term, Relapsing Alcohol Drinking in Primates

2011 ◽  
Vol 36 (12) ◽  
pp. 2513-2528 ◽  
Author(s):  
Verginia C Cuzon Carlson ◽  
Gail K Seabold ◽  
Christa M Helms ◽  
Natasha Garg ◽  
Misa Odagiri ◽  
...  
Keyword(s):  
Alcohol Drinking

MICROARRAY-BASED GENE EXPRESSION PROFILING IN LONG-TERM ALCOHOL DRINKING AA-, P-, AND HAD-RATS.

2004 ◽  
Vol 28 (Supplement) ◽  
pp. 57A
Author(s):  
R Spanagel ◽  
F Leonardi-Essmann ◽  
P J. Gebicke-Haerter
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Alcohol Drinking ◽  
Expression Profiling
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