Potentially inappropriate medicines for older adults with intellectual disability: Clinical implications from a medication audit

Abstract There are limited studies on the prevalence of epilepsy and co-morbid conditions in older adults with an ID. To begin to address this prevalence of epilepsy was estimated for participants in the Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing. Associations with demographic variables and co morbid health conditions were examined. It was found that prevalence was high (30.7%); but declined as people aged. Those with epilepsy were less likely to live with family, independently or in community settings, rates of refractory epilepsy were high and, despite medication over half of those with epilepsy still reported experiencing seizures. Given these findings, people with ID and their careers have considerable needs for information about epilepsy management, and for support from specialist ID and epilepsy services.

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The use of proton pump inhibitors among older adults with intellectual disability: A cross sectional observational study

Saudi Pharmaceutical Journal ◽

10.1016/j.jsps.2018.05.009 ◽

2018 ◽

Vol 26 (7) ◽

pp. 1012-1021

Author(s):

Hadiah AlMutairi ◽

Máire O'Dwyer ◽

Mary McCarron ◽

Philip McCallion ◽

Martin C. Henman

Keyword(s):

Older Adults ◽

Intellectual Disability ◽

Observational Study ◽

Proton Pump Inhibitors ◽

Proton Pump ◽

Cross Sectional

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Older adults with intellectual disability

Current Opinion in Psychiatry ◽

10.1097/yco.0b013e328355ab26 ◽

2012 ◽

Vol 25 (5) ◽

pp. 359-364 ◽

Cited By ~ 28

Author(s):

Amanda Sinai ◽

Ingrid Bohnen ◽

Andre Strydom

Keyword(s):

Older Adults ◽

Intellectual Disability

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298ASSOCIATIONS BETWEEN MEDICATION USE AND FALLS AMONG OLDER ADULTS WITH INTELLECTUAL DISABILITY IN IRELAND

Age and Ageing ◽

10.1093/ageing/afw159.51 ◽

2016 ◽

Vol 45 (suppl 2) ◽

pp. ii1.51-ii12

Author(s):

Sinead Foran ◽

Maire O Dwyer ◽

Mary McCarron ◽

Martin Henman ◽

Philip McCallion

Keyword(s):

Older Adults ◽

Intellectual Disability ◽

Medication Use

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Causes of Mortality in Older People With Intellectual Disability: Results From the HA-ID Study

American Journal on Intellectual and Developmental Disabilities ◽

10.1352/1944-7558-123.1.61 ◽

2018 ◽

Vol 123 (1) ◽

pp. 61-71 ◽

Cited By ~ 11

Author(s):

Alyt Oppewal ◽

Josje D. Schoufour ◽

Hanne J.K. van der Maarl ◽

Heleen M. Evenhuis ◽

Thessa I.M. Hilgenkamp ◽

...

Keyword(s):

Older Adults ◽

Intellectual Disability ◽

Cause Of Death ◽

Causes Of Death ◽

Circulatory System ◽

Bacterial Diseases ◽

Specific Mortality ◽

Causes Of Mortality ◽

Insight Into

Abstract We aim to provide insight into the cause-specific mortality of older adults with intellectual disability (ID), with and without Down syndrome (DS), and compare this to the general population. Immediate and primary cause of death were collected through medical files of 1,050 older adults with ID, 5 years after the start of the Healthy Ageing and Intellectual Disabilities (HA-ID) study. During the follow-up period, 207 (19.7%) participants died, of whom 54 (26.1%) had DS. Respiratory failure was the most common immediate cause of death (43.4%), followed by dehydration/malnutrition (20.8%), and cardiovascular diseases (9.4%). In adults with DS, the most common cause was respiratory disease (73.3%), infectious and bacterial diseases (4.4%), and diseases of the digestive system (4.4%). Diseases of the respiratory system also formed the largest group of primary causes of death (32.1%; 80.4% was due to pneumonia), followed by neoplasms (17.6%), and diseases of the circulatory system (8.2%). In adults with DS, the main primary cause was also respiratory diseases (51.1%), followed by dementia (22.2%).

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Comparative characterization of PCDH19 missense and truncating variants in PCDH19-related epilepsy

Journal of Human Genetics ◽

10.1038/s10038-020-00880-z ◽

2020 ◽

Author(s):

Mami Shibata ◽

Atsushi Ishii ◽

Ayako Goto ◽

Shinichi Hirose

Keyword(s):

Distribution Function ◽

Intellectual Disability ◽

Cumulative Distribution Function ◽

Clinical Phenotype ◽

Cytoplasmic Domain ◽

Cumulative Distribution ◽

Clinical Implications ◽

Healthy Individuals ◽

Conserved Domains

AbstractMissense and truncating variants in protocadherin 19 (PCDH19) cause PCDH19-related epilepsy. In this study, we aimed to investigate variations in distributional characteristics and the clinical implications of variant type in PCDH19-related epilepsy. We comprehensively collected PCDH19 missense and truncating variants from the literature and by sequencing six exons and intron–exon boundaries of PCDH19 in our cohort. We investigated the distribution of each type of variant using the cumulative distribution function and tested for associations between variant types and phenotypes. The distribution of missense variants in patients was clearly different from that of healthy individuals and was uniform throughout the extracellular cadherin (EC) domain, which consisted of six highly conserved domains. Truncating variants showed two types of distributions: (1) located from EC domain 1 to EC domain 4, and (2) located from EC domain 5 to the cytoplasmic domain. Furthermore, we also found that later onset seizures and milder intellectual disability occurred in patients with truncating variants located from EC domain 5 to the cytoplasmic domain compared with those of patients with other variants. Our findings provide the first evidence of two types of truncating variants in the PCDH19 gene with regard to distribution and the resulting clinical phenotype.

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