P30: A humanized mouse model of gestational diabetes mellitus mimicking metabolic and immune pathologies of human pregnancy complication

2021 ◽  
Vol 85 (S1) ◽  
pp. 77-77
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Mouse Model ◽  
Gestational Diabetes Mellitus ◽  
Pregnancy Complication ◽  
Humanized Mouse ◽  
Humanized Mouse Model ◽  
Human Pregnancy

Abstract 390: A New Humanized Mouse Model to Study Lipid Abnormalities and HDL Function in Poorly Controlled Type 1 Diabetes Mellitus

2018 ◽  
Vol 38 (Suppl_1) ◽  
Author(s):  
Vishal Kothari ◽  
Yi He ◽  
Farah Kramer ◽  
Shelley Barnhart ◽  
Jenny E Kanter ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Mouse Model ◽  
Type 1 Diabetes Mellitus ◽  
Humanized Mouse ◽  
Humanized Mouse Model ◽  
Hdl Function ◽  
Lipid Abnormalities

scholarly journals Gestational Diabetes Mellitus Affects Offspring’s Epigenome. Is There a Way to Reduce the Negative Consequences?

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2792
Author(s):  
Monika Słupecka-Ziemilska ◽  
Piotr Wychowański ◽  
Monika Puzianowska-Kuznicka
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnancy Complication ◽  
Epigenetic Changes ◽  
Negative Consequences ◽  
Short Term ◽  
Related Factors ◽  
Epigenetic Programming

Gestational diabetes mellitus (GDM) is the most common pregnancy complication worldwide and may result in short-term and long-term consequences for offspring. The present review highlights evidence of epigenetic programming, mostly from human studies, which occurs in offspring exposed to maternal GDM during different stages of development, paying special attention to the differences in sensitivity of offspring to maternal hyperglycemia as a result of sex-related factors. We also aim to answer the following question: If these epigenetic changes are constant throughout the lifetime of the offspring, how do they present phenotypically?

scholarly journals Gestational diabetes mellitus: a (nearly) perfect mouse model

2019 ◽  
Vol 597 (18) ◽  
pp. 4689-4690
Author(s):  
N. Blysniuk ◽  
A. Visram ◽  
K. T. Lam
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Mouse Model ◽  
Gestational Diabetes Mellitus

scholarly journals Immunobiology of Gestational Diabetes Mellitus in Post-Medawar Era

2022 ◽  
Vol 12 ◽  
Author(s):  
Surendra Sharma ◽  
Sayani Banerjee ◽  
Paula M. Krueger ◽  
Sandra M. Blois
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Immune Responses ◽  
Gestational Diabetes Mellitus ◽  
Systemic Inflammation ◽  
Pregnancy Complication ◽  
Low Grade ◽  
Autoimmune Pathology ◽  
Treg Population ◽  
Maternal Fetal Interface

Although the concepts related to fetal immune tolerance proposed by Sir Peter Medawar in the 1950s have not withstood the test of time, they revolutionized our current understanding of the immunity at the maternal-fetal interface. An important extension of the original Medawar paradigm is the investigation into the underlying mechanisms for adverse pregnancy outcomes, including recurrent spontaneous abortion, preterm birth, preeclampsia and gestational diabetes mellitus (GDM). Although a common pregnancy complication with systemic symptoms, GDM still lacks understanding of immunological perturbations associated with the pathological processes, particularly at the maternal-fetal interface. GDM has been characterized by low grade systemic inflammation that exacerbates maternal immune responses. In this regard, GDM may also entail mild autoimmune pathology by dysregulating circulating and uterine regulatory T cells (Tregs). The aim of this review article is to focus on maternal-fetal immunological tolerance phenomenon and discuss how local or systemic inflammation has been programmed in GDM. Specifically, this review addresses the following questions: Does the inflammatory or exhausted Treg population affecting the Th17:Treg ratio lead to the propensity of a pro-inflammatory environment? Do glycans and glycan-binding proteins (mainly galectins) contribute to the biology of immune responses in GDM? Our understanding of these important questions is still elementary as there are no well-defined animal models that mimic all the features of GDM or can be used to better understand the mechanistic underpinnings associated with this common pregnancy complication. In this review, we will leverage our preliminary studies and the literature to provide a conceptualized discussion on the immunobiology of GDM.

scholarly journals Effects of Astaxanthin on Inflammation and Insulin Resistance in a Mouse Model of Gestational Diabetes Mellitus

Dose-Response ◽  
2020 ◽  
Vol 18 (2) ◽  
pp. 155932582092676
Author(s):  
Weihong Feng ◽  
Yanxia Wang ◽  
Na Guo ◽  
Pu Huang ◽  
Yang Mi
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Gestational Diabetes ◽  
Glucose Tolerance ◽  
Mouse Model ◽  
Gestational Diabetes Mellitus ◽  
The Body ◽  
Ros Generation

Gestational diabetes mellitus (GDM) is a condition in which a hormone made by the placenta prevents the body from using insulin effectively. It is important to find an effective treatment. A mouse model of GDM was used to testify the effects of astaxanthin on glucose tolerance and insulin sensitivity. Production of inflammatory cytokines, reactive oxygen species (ROS), and glucose transporter type 4 (GLUT4) translocation and insulin-related signaling were measured in the presence of astaxanthin both in vivo and in vitro. It was found that astaxanthin improved insulin sensitivity, glucose tolerance, and litter size of offspring and reduced birth weight of offspring and inflammation in GDM mouse. Moreover, astaxanthin increased GLUT4 translocating to membrane without altering its secretion/expression and glucose uptake and consumption in C2C12 skeletal muscle cells. Furthermore, ROS generation and insulin-related signaling inhibited by tumor necrosis factor α was restored by astaxanthin. It is concluded that astaxanthin has the potential to attenuate GDM symptoms by regulating inflammation and insulin resistance in skeletal muscle of pregnant mice. Our findings suggest that astaxanthin could be a promising and effective molecule to treat GDM.

scholarly journals The Effects of Myo-Inositol and B and D Vitamin Supplementation in the db/+ Mouse Model of Gestational Diabetes Mellitus

Nutrients ◽  
2017 ◽  
Vol 9 (2) ◽  
pp. 141 ◽  
Author(s):  
Jasmine Plows ◽  
Florence Budin ◽  
Rebecka Andersson ◽  
Valerie Mills ◽  
Katherine Mace ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Mouse Model ◽  
Gestational Diabetes Mellitus ◽  
Vitamin Supplementation
Sign in / Sign up

Export Citation Format

Share Document