Human basophil chemotaxis and activation are regulated via the histamine H4 receptor

Allergy ◽  
2016 ◽  
Vol 71 (9) ◽  
pp. 1264-1273 ◽  
Author(s):  
S. Mommert ◽  
S. Kleiner ◽  
M. Gehring ◽  
B. Eiz-Vesper ◽  
H. Stark ◽  
...  
Keyword(s):  
Human Basophil ◽  
Histamine H4 Receptor ◽  
H4 Receptor

Targeting the Histamine H4 Receptor: Future Drugs for Inflammatory Diseases

2018 ◽  
Vol 22 (17) ◽  
pp. 1663-1672 ◽  
Author(s):  
Michelle Fidelis Correa ◽  
Joao Paulo dos Santos Fernandes
Keyword(s):  
Inflammatory Diseases ◽  
Histamine H4 Receptor ◽  
H4 Receptor

scholarly journals Mouse Colonic Epithelial Cells Functionally Express the Histamine H4 Receptor

2020 ◽  
Vol 373 (2) ◽  
pp. 167-174 ◽  
Author(s):  
Bastian Schirmer ◽  
Luisa Lindemann ◽  
Kaya Saskia Bittkau ◽  
Rukijat Isaev ◽  
Daniela Bösche ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Histamine H4 Receptor ◽  
Colonic Epithelial Cells ◽  
H4 Receptor

Hepatic gene expression in genetically histamine H4 receptor deficient mice in normal and inflammatory conditions

2007 ◽  
Vol 56 (S1) ◽  
pp. S49-S50 ◽  
Author(s):  
A. K. Fülöp ◽  
D. Ribita ◽  
A. Falus
Keyword(s):  
Gene Expression ◽  
Hepatic Gene Expression ◽  
Histamine H4 Receptor ◽  
Inflammatory Conditions ◽  
H4 Receptor ◽  
Deficient Mice

Allergic inflammation is augmented via histamine H4 receptor activation: The role of natural killer cells in vitro and in vivo

2016 ◽  
Vol 83 (2) ◽  
pp. 106-115 ◽  
Author(s):  
Sarah Ehling ◽  
Kristine Roßbach ◽  
Stanley M. Dunston ◽  
Holger Stark ◽  
Wolfgang Bäumer
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Allergic Inflammation ◽  
Receptor Activation ◽  
Histamine H4 Receptor ◽  
Killer Cells ◽  
H4 Receptor

scholarly journals Liver-Expressed Chemokine/CC Chemokine Ligand 16 Attracts Eosinophils by Interacting with Histamine H4 Receptor

2004 ◽  
Vol 173 (3) ◽  
pp. 2078-2083 ◽  
Author(s):  
Takashi Nakayama ◽  
Yoshiko Kato ◽  
Kunio Hieshima ◽  
Daisuke Nagakubo ◽  
Yuichi Kunori ◽  
...  
Keyword(s):  
Histamine H4 Receptor ◽  
Cc Chemokine ◽  
Chemokine Ligand ◽  
H4 Receptor

scholarly journals The Function of the Histamine H4 Receptor in Inflammatory and Inflammation-Associated Diseases of the Gut

2021 ◽  
Vol 22 (11) ◽  
pp. 6116
Author(s):  
Bastian Schirmer ◽  
Detlef Neumann
Keyword(s):  
Inflammatory Diseases ◽  
Allergic Inflammation ◽  
Histamine H4 Receptor ◽  
Ongoing Research ◽  
Inflammatory Reactions ◽  
Beneficial Effects ◽  
Associated Diseases ◽  
Physiological Processes ◽  
H4 Receptor ◽  
Deficient Mice

Histamine is a pleiotropic mediator involved in a broad spectrum of (patho)-physiological processes, one of which is the regulation of inflammation. Compounds acting on three out of the four known histamine receptors are approved for clinical use. These approved compounds comprise histamine H1-receptor (H1R) antagonists, which are used to control allergic inflammation, antagonists at H2R, which therapeutically decrease gastric acid release, and an antagonist at H3R, which is indicated to treat narcolepsy. Ligands at H4R are still being tested pre-clinically and in clinical trials of inflammatory diseases, including rheumatoid arthritis, asthma, dermatitis, and psoriasis. These trials, however, documented only moderate beneficial effects of H4R ligands so far. Nevertheless, pre-clinically, H4R still is subject of ongoing research, analyzing various inflammatory, allergic, and autoimmune diseases. During inflammatory reactions in gut tissues, histamine concentrations rise in affected areas, indicating its possible biological effect. Indeed, in histamine-deficient mice experimentally induced inflammation of the gut is reduced in comparison to that in histamine-competent mice. However, antagonists at H1R, H2R, and H3R do not provide an effect on inflammation, supporting the idea that H4R is responsible for the histamine effects. In the present review, we discuss the involvement of histamine and H4R in inflammatory and inflammation-associated diseases of the gut.

scholarly journals An Immunohistochemical Investigation of Renal Phospholipidosis and Toxicity in Rats

2017 ◽  
Vol 36 (5) ◽  
pp. 386-394 ◽  
Author(s):  
Jing Ying Ma ◽  
Sandra Snook ◽  
Sheryl Garrovillo ◽  
Charles Johnson ◽  
David La
Keyword(s):  
Electron Microscopy ◽  
Membrane Protein ◽  
Kidney Injury ◽  
Tubular Epithelial Cell ◽  
Vehicle Group ◽  
Tubular Injury ◽  
Histamine H4 Receptor ◽  
Outer Stripe ◽  
H4 Receptor ◽  
Renal Tubular

Immunohistochemical staining for the lysosome-associated membrane protein 2 (LAMP-2) has been proposed previously as an alternative to electron microscopy to identify hepatic phospholipidosis. This study used LAMP-2 immunohistochemistry (IHC) to diagnose phospholipidosis in rats exhibiting renal tubular injury. Rats were administered toreforant, a histamine H4 receptor antagonist by oral gavage at a dose of 3, 10, or 100 mg/kg/d for 6 months. Hematoxylin and eosin staining revealed renal tubular epithelial cell vacuolation, hypertrophy, degeneration, and luminal dilation in the 100 mg/kg/d group animals. Renal tubular injury was confirmed using kidney injury marker 1 (KIM-1) IHC. The involvement of phosopholipidosis in the renal injury was investigated by LAMP-2. Adipophilin IHC was included to differentiate phospholipidosis from lipidosis. Increased LAMP-2 staining was observed in the 100 mg/kg/d group animals when compared to vehicle group animals. Lysosome-associated membrane protein-2 staining was most prominent in the outer stripe of the outer medulla where KIM-1 staining was also most prominent. By contrast, adipophilin staining was not increased. Phospholipidosis was also confirmed by electron microscopy. These data support the use of LAMP-2 IHC as a diagnostic tool and suggest an association between phospholipidosis and the renal tubular injury caused by toreforant.

Basophils Contribute To Allergic Rhinitis Through Engagement Of The Histamine H4 Receptor

2011 ◽  
Author(s):  
Yoshiki Shiraishi ◽  
Katsuyuki Takeda ◽  
Yi Jia ◽  
Joanne Domenico ◽  
Robin L. Thurmond ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Histamine H4 Receptor ◽  
H4 Receptor
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