The evolution of IgE‐mediated type I hypersensitivity and its immunological value

AbstractHistamine is a monoamine synthesized from the amino acid histidine that is well-known for its role in IgE-mediated anaphylaxis but has shown pleiotropic effects on the immune system, especially in order to promote inflammatory responses. H1-receptor antagonist are common drugs used in mild/moderate allergic reactions whereas H2-receptor antagonist are commonly administered in gastric ulcer but showed some properties in allergy too. The EAACI guidelines for diagnosis and treatment of anaphylactic reactions recommend their use as third-line therapy in adjunct to H1-antagonists. The purpose of this article is to produce a complete summary of findings and evidence known so far about the usefulness of H2-receptor antagonist in allergic reactons.

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Morin inhibits Fyn kinase in mast cells and IgE-mediated type I hypersensitivity response in vivo

Biochemical Pharmacology ◽

10.1016/j.bcp.2009.01.019 ◽

2009 ◽

Vol 77 (9) ◽

pp. 1506-1512 ◽

Cited By ~ 50

Author(s):

Jie Wan Kim ◽

Jun Ho Lee ◽

Bang Yeon Hwang ◽

Se Hwan Mun ◽

Na Young Ko ◽

...

Keyword(s):

Mast Cells ◽

Type I ◽

Hypersensitivity Response ◽

Fyn Kinase ◽

Ige Mediated ◽

Type I Hypersensitivity

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Profile of the canine population with atopic dermatitis at the dermatology service of the Veterinary Hospital from Federal University of Minas Gerais

Research Society and Development ◽

10.33448/rsd-v10i11.19645 ◽

2021 ◽

Vol 10 (11) ◽

pp. e378101119645

Author(s):

Jéssica Ragazzi Calesso ◽

Vanessa Stuart Marques ◽

Adriane Pimenta da Costa-Val Bicalho

Keyword(s):

Atopic Dermatitis ◽

Skin Barrier ◽

Minas Gerais ◽

Type I ◽

Mixed Breed ◽

Canine Population ◽

Ige Mediated ◽

Genetic And Environmental Factors ◽

Type I Hypersensitivity ◽

Veterinary Hospital

Canine atopic dermatitis (AD) is an IgE-mediated type I hypersensitivity reaction to sensitization to environmental allergens. Pathogenesis is quite complex, involving genetic and environmental factors, food allergens, skin barrier defects and immune dysfunction. Data on its prevalence and epidemiological aspects in Europe and North America are easily found in the literature. However, when searching for specific national locations, studies are still scarce. Thus, the objective of this study was to determine the prevalence and characteristics of canine AD at the dermatology service of the Veterinary Hospital from Federal University of Minas Gerais (UFMG). For this purpose, 761 medical records of dogs attended at the service from January 2015 to December 2020 were analyzed. The results revealed that of all dermatological diagnoses in the species, 28,12% (214/761) of the cases were of dogs with AD. 34,51% (291/761) of the dermatological cases were from allergic etiology, and of these, AD corresponded to 73,56% (214/291), representing the most prevalent allergic disease in dogs at the Veterinary Hospital from UFMG. Females were more affected than males, as well as dogs of defined breeds in comparison to mixed breed dogs, with shih tzu being the most prevalent pure breed, followed by mixed breed dogs. Because it is a highly pruritic disease that affects the quality of life of dogs and their owners, this study contributes to a better understanding and diagnostic approach to the disease in the local canine population.

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Anaphylaxis

Emergencies in Respiratory Medicine ◽

10.1093/med/9780199202447.003.0018 ◽

2007 ◽

pp. 109-112

Keyword(s):

Hypersensitivity Reaction ◽

Specific Antigen ◽

Platelet Activating Factor ◽

Prior Exposure ◽

Type I ◽

Subsequent Exposure ◽

Mucosal Oedema ◽

Ige Mediated ◽

The Individual ◽

Type I Hypersensitivity

Anaphylaxis 110 Anaphylactic reactions (type I hypersensitivity reaction) are the consequence of the cascade caused by an IgE-mediated response to a specific antigen. Prior exposure to the antigen sensitizes the individual, so that subsequent exposure results in prostaglandin, leukotriene, and platelet activating factor generation and thereby histamine release. This results in vasodilatation, bronchial mucosal oedema, and bronchoconstriction....

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Protein and Antibody Engineering: Suppressing Degranulation of the Mast Cells and Type I Hypersensitivity Reaction

Current Protein and Peptide Science ◽

10.2174/1389203721666200511094717 ◽

2020 ◽

Vol 21 (8) ◽

pp. 831-841

Author(s):

Huda Fatima Rajani ◽

Solmaz Shahidi ◽

Mohammad Mahmoudi Gomari

Keyword(s):

Mast Cells ◽

Hypersensitivity Reaction ◽

Review Paper ◽

Antibody Engineering ◽

Type I ◽

Hypersensitivity Response ◽

Ige Mediated ◽

Biological Environment ◽

Type I Hypersensitivity

With an increase in atopic cases and owing to a significant role of mast cells in type I hypersensitivity, a therapeutic need to inhibit degranulation of mast cells has risen. Mast cells are notorious for IgE-mediated allergic response. Advancements have allowed researchers to improve clinical outcomes of already available therapies. Engineered peptides and antibodies can be easily manipulated to attain desired characteristics as per the biological environment. A number of these molecules are designed to target mast cells in order to regulate the release of histamine and other mediators, thereby controlling type I hypersensitivity response. The aim of this review paper is to highlight some of the significant molecules designed for the purpose.

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Molecular insight into Nickel(II) binding by Her2-specific IgE: a possible mechanistic insight into the pathogenesis of Type I nickel hypersensitivity

10.1101/2020.07.14.203539 ◽

2020 ◽

Author(s):

Chinh Tran-To Su ◽

Wai-Heng Lua ◽

Jun-Jie Poh ◽

Wei-Li Ling ◽

Joshua Yi Yeo ◽

...

Keyword(s):

Specific Ige ◽

Type I ◽

Type Iv ◽

Mechanistic Insight ◽

Ige Mediated ◽

Underlying Mechanisms ◽

Type I Hypersensitivity ◽

Insight Into ◽

Shed Light ◽

Selection Of

SUMMARYNickel (Ni) allergy has been reported in contact dermatitis Type IV (Ni-specific T cells mediated) and asthmatic Type I (IgE-mediated) hypersensitivities. Associations between the two hypersensitivities have been found in some patients, but the underlying mechanisms remain enigmatic. Using Her2-specific IgEs as models, we found additional binding to Ni-NTA without observable changes in binding to Her2 and that glutamine, together with the canonical Ni2+-binding histidine, could form Ni2+ binding signatures. This mechanism may underlie Type I hypersensitivity in the selection of anti-Ni2+ IgEs. This mechanism may also underlie Type IV hypersensitivity and the interaction of immunoglobulin proteins with other heavy metal ions. Our findings shed light to how Ni hypersensitivities can occur and how they can be avoided in therapeutics design, or even incorporated for biotechnological purification purposes.

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