Antioxidant enzymes activity, lipid peroxidation, oxidative damage in the testis and epididymis, and steroidogenesis in rats after co-exposure to atrazine and ethanol

Andrologia ◽  
2015 ◽  
Vol 48 (5) ◽  
pp. 548-557 ◽  
Author(s):  
S. O. Abarikwu ◽  
Q. C. Duru ◽  
O. V. Chinonso ◽  
R.-C. Njoku
2012 ◽  
Vol 134 (3-4) ◽  
pp. 184-190 ◽  
Author(s):  
Agnieszka Partyka ◽  
Ewa Łukaszewicz ◽  
Wojciech Niżański

2005 ◽  
Vol 30 (2) ◽  
pp. 186-195 ◽  
Author(s):  
Helga Ogonovszky ◽  
Maria Sasvári ◽  
Agoston Dosek ◽  
István Berkes ◽  
Takao Kaneko ◽  
...  

Physical exercise above a certain load has been suggested as being a cause of oxidative stress. We have tested whether training with moderate (MT), strenuous (ST), or over (OT) load can cause alterations in the activities of antioxidant enzymes, lipid peroxidation, protein oxidation, DNA damage, or activity of 8-oxoG-DNA glycosylase (OGG1) in rat liver. The levels of corticosterone decreased in all exercising groups but the differences were not significant. Adrenocorticotrophin hormone (ACTH) levels decreased, not significantly, in MT and OT compared to C. Activity levels of antioxidant enzymes did not change significantly in the liver. The levels of reactive carbonyl derivative (RCD) content decreased in the liver of exercising animals, and the differences reached significance between control and moderately trained groups. The changes in the levels of lipid peroxidation (LIPOX) were not significant, but were lower in the exercised groups. The 8-hydroxydeoxyguanosine (8-OHdG) levels increased in the OT group, and the activity of OGG1 measured from crude cell extracts tended to increase in MT and ST. The findings of this study imply that overtraining induces oxidative damage to nuclear DNA, but not to liver lipids and proteins. Key words: exercise, oxidative damage, adaptation, OGG1


2009 ◽  
Vol 25 (8) ◽  
pp. 557-563 ◽  
Author(s):  
Sameeh A Mansour ◽  
Abdel-Tawab H Mossa ◽  
Tarek M Heikal

Erythrocytes are a convenient model to understand the membrane oxidative damage induced by various xenobiotic pro-oxidants. This study was designed to investigate the possibility of methomyl (Lannate® 90% SP), S-methyl N-(methylcarbamoyloxy) thioacetimidate, to induce oxidative stress response in rat erythrocytes in vitro. Erythrocytes were incubated for 4 hours at 37°C with different concentrations (0.0, 0.1, 0.5, 1.0, 1.5 and 2.0 mM) of methomyl. The results showed that methomyl decreased acetylcholinesterase (AChE), superoxide dismutase (SOD) and glutathione S-transferase (GST) activities and increased level of lipid peroxidation (LPO) as well as the percentage of haemolysis. The response occurred in a concentration-dependent manner. The study suggested that methomyl has the capability to induce oxidative damage as evidenced by increasing LPO and perturbations in various antioxidant enzymes.


2013 ◽  
Vol 12 (1) ◽  
pp. 315 ◽  
Author(s):  
Camila Fabbri ◽  
Rita de Cássia Mascarenhas-Netto ◽  
Pritesh Lalwani ◽  
Gisely C Melo ◽  
Belisa ML Magalhães ◽  
...  

2004 ◽  
Vol 42 (3) ◽  
pp. 429-438 ◽  
Author(s):  
M Jurczuk ◽  
M M. Brzóska ◽  
J Moniuszko-Jakoniuk ◽  
M Gałażyn-Sidorczuk ◽  
E Kulikowska-Karpińska

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