The protective effect of esculetin against aluminium chloride‐induced reproductive toxicity in rats

Andrologia ◽  
2020 ◽  
Author(s):  
Erdinç Türk ◽  
Ibrahim Ozan Tekeli ◽  
Hüseyin Özkan ◽  
Ahmet Uyar ◽  
Mustafa Cellat ◽  
...  
Keyword(s):  
Protective Effect ◽  
Reproductive Toxicity ◽  
Aluminium Chloride

scholarly journals Protective Effect of Propolis against Aluminium Chloride Reproductive Toxicity Histopathological and Ultrastruchtural Study

2020 ◽  
pp. 1-10
Author(s):  
Essam Eldin Abdelhady Salama
Keyword(s):  
Mechanical Properties ◽  
Wound Healing ◽  
Free Radical ◽  
Herpes Simplex ◽  
Protective Effect ◽  
Harmful Effect ◽  
Reproductive Toxicity ◽  
Antimicrobial Properties ◽  
Aluminium Chloride ◽  
Male Rats

Human impact on the environment was steadily increasing the amounts of aluminum in the ecosystems. This element accumulated in plants and water. Potentially increased its harmful effect; particularly, it induced free radical-mediated cytotoxicity and reproductive toxicity. Propolis was a resinous material collected by bees from bud and exudates of the plants, mixed with bee enzymes, pollen, and wax. Due to its waxy nature and mechanical properties, bees used propolis in the construction and repair of their hives, and as a protective barrier against external invaders, or weathering threats, Current antimicrobial properties of propolis, was helping for wound healing, treatment of burns, herpes simplex and genital herpes. The present work studied the protective effect of propolis against the reproductive toxicity of aluminum chloride in male rats.

scholarly journals Protective effect of Centella asiatica against D-galactose and aluminium chloride induced rats: Behavioral and ultrastructural approaches

2019 ◽  
Vol 109 ◽  
pp. 853-864 ◽  
Author(s):  
Samaila Musa Chiroma ◽  
Mohamad Taufik Hidayat Baharuldin ◽  
Che Norma Mat Taib ◽  
Zulkhairi Amom ◽  
Saravanan Jagadeesan ◽  
...  
Keyword(s):  
Protective Effect ◽  
Centella Asiatica ◽  
Aluminium Chloride

An in vitro study on reproductive toxicity of aluminium chloride on rabbit sperm: The protective role of some antioxidants

Toxicology ◽  
2007 ◽  
Vol 239 (3) ◽  
pp. 213-223 ◽  
Author(s):  
Mokhtar I. Yousef ◽  
Kamel I. Kamel ◽  
Marwa I. El-Guendi ◽  
Fatma M. El-Demerdash
Keyword(s):  
Reproductive Toxicity ◽  
In Vitro Study ◽  
Protective Role ◽  
Vitro Study ◽  
Aluminium Chloride

Chemoprotection of ethylene glycol monoethyl ether-induced reproductive toxicity in male rats by kolaviron, isolated biflavonoid from Garcinia kola seed

2011 ◽  
Vol 31 (5) ◽  
pp. 506-517 ◽  
Author(s):  
IA Adedara ◽  
EO Farombi
Keyword(s):  
Vitamin E ◽  
Ethylene Glycol ◽  
Protective Effect ◽  
Reproductive Toxicity ◽  
Male Rats ◽  
Antioxidant Systems ◽  
Sod Activity ◽  
Garcinia Kola ◽  
Monoethyl Ether ◽  
Glycol Monoethyl Ether

The present study investigated the protective effect of kolaviron, a biflavonoid from the seed of Garcinia kola, on ethylene glycol monoethyl ether (EGEE)–induced reproductive toxicity in male rats. The protective effect of kolaviron was validated using vitamin E, a standard antioxidant. EGEE was administered at a dose of 200 mg/kg. Other groups of rats were simultaneously treated with kolaviron (100 and 200 mg/kg) and vitamin E (50 mg/kg) for 14 days. EGEE treatment resulted in significant decrease in glutathione (GSH) level, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities but markedly increased the glutathione-S-transferase (GST) and lactate dehydrogenase (LDH) activities in the testes. In the spermatozoa, administration of EGEE caused significant decrease in the activities of CAT, GPx, GST and LDH as well as in the level of GSH but significantly increased SOD activity with concomitant increase in hydrogen peroxide and malondialdehyde levels in both testes and spermatozoa. EGEE-exposed rats showed marked testicular degeneration with concomitant decrease in spermatozoa quantity and quality. Overall, EGEE causes reproductive dysfunction in rats by altering antioxidant systems in the testes and spermatozoa. Kolaviron or vitamin E exhibited protective effects against EGEE-induced male reproductive toxicity by enhancement of antioxidant status and improvement in spermatozoa quantity and quality.

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