THE PROTECTIVE EFFECT OF IRBESARTAN AGAINST BLEOMYCIN-INDUCED MALE RATS REPRODUCTIVE TOXICITY

2021 ◽  
Vol 24 (04) ◽  
Author(s):  
MAHDI M. THUWAINI
Keyword(s):  
Protective Effect ◽  
Reproductive Toxicity ◽  
Male Rats

Chemoprotection of ethylene glycol monoethyl ether-induced reproductive toxicity in male rats by kolaviron, isolated biflavonoid from Garcinia kola seed

2011 ◽  
Vol 31 (5) ◽  
pp. 506-517 ◽  
Author(s):  
IA Adedara ◽  
EO Farombi
Keyword(s):  
Vitamin E ◽  
Ethylene Glycol ◽  
Protective Effect ◽  
Reproductive Toxicity ◽  
Male Rats ◽  
Antioxidant Systems ◽  
Sod Activity ◽  
Garcinia Kola ◽  
Monoethyl Ether ◽  
Glycol Monoethyl Ether

The present study investigated the protective effect of kolaviron, a biflavonoid from the seed of Garcinia kola, on ethylene glycol monoethyl ether (EGEE)–induced reproductive toxicity in male rats. The protective effect of kolaviron was validated using vitamin E, a standard antioxidant. EGEE was administered at a dose of 200 mg/kg. Other groups of rats were simultaneously treated with kolaviron (100 and 200 mg/kg) and vitamin E (50 mg/kg) for 14 days. EGEE treatment resulted in significant decrease in glutathione (GSH) level, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities but markedly increased the glutathione-S-transferase (GST) and lactate dehydrogenase (LDH) activities in the testes. In the spermatozoa, administration of EGEE caused significant decrease in the activities of CAT, GPx, GST and LDH as well as in the level of GSH but significantly increased SOD activity with concomitant increase in hydrogen peroxide and malondialdehyde levels in both testes and spermatozoa. EGEE-exposed rats showed marked testicular degeneration with concomitant decrease in spermatozoa quantity and quality. Overall, EGEE causes reproductive dysfunction in rats by altering antioxidant systems in the testes and spermatozoa. Kolaviron or vitamin E exhibited protective effects against EGEE-induced male reproductive toxicity by enhancement of antioxidant status and improvement in spermatozoa quantity and quality.

scholarly journals Vitamin B17 Ameliorates Methotrexate-Induced Reproductive Toxicity, Oxidative Stress, and Testicular Injury in Male Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-11 ◽  
Author(s):  
Shatha G. Felemban ◽  
Maha A. Aldubayan ◽  
Ahmad H. Alhowail ◽  
Ibtesam S. Almami
Keyword(s):  
Protective Effect ◽  
Antioxidant Properties ◽  
Reproductive Toxicity ◽  
Male Rats ◽  
Nuclear Antigen ◽  
Plasma Testosterone ◽  
Control Group ◽  
Albino Rats ◽  
Testicular Toxicity ◽  
Testicular Weight

Methotrexate (MTX; 4-amino-10-methylfolic acid) is a folic acid reductase inhibitor used to treat autoimmune diseases and certain types of cancer. Testicular toxicity resulting from MTX is a significant side effect that may cause subsequent infertility. The present study was conducted to examine the ameliorating effects of vitamin B17 (VitB17) against testicular toxicity induced by MTX in male rats. A total of 50 male albino rats were equally divided into five groups [control group; vitamin B17 group (VitB17) administered VitB17 only; methotrexate group administered MTX only; cotreated group, (VitB17+MTX) and posttreated group (MTX+VitB17)]. In methotrexate group (MTX), a significant decrease was observed in body weight and the testicular weight, as well as the levels of plasma testosterone, luteinizing hormone and follicle-stimulating hormone compared with control. The sperm count, viability, morphology index, total motility, and progressive motility also decreased in MTX rats compared with control. Furthermore, the levels of reduced glutathione, catalase, and superoxide dismutase, as well as proliferating cell nuclear antigen protein expression, in the testicular tissue decreased in MTX compared with control. In addition, MTX caused a significant increase in DNA and tissue damage compared with control. However, VitB17 ameliorated these effects, indicating that it has a preventative and curative effect against MTX-induced reproductive toxicity in male rats. The protective effect of VitB17 may be associated to its antioxidant properties as it possibly acts as a free-radical scavenger and lipid peroxidation inhibitor, as well as its protective effect on the levels of GSH, SOD, and CAT.

scholarly journals Protective effect of propolis against aluminum chloride-induced reproductive toxicity in male rats

2021 ◽  
Vol 9 (2) ◽  
pp. 083-088
Author(s):  
Essam Eldin Abdelhady Salama ◽  
Ahmed Fathalla El Fouhil ◽  
Khaleel Ibrahim Alyahya ◽  
Sameerah Yasain Shaheen ◽  
Sanaa Ahmed Alshaarawy ◽  
...  
Keyword(s):  
Protective Effect ◽  
Aluminum Chloride ◽  
Testosterone Level ◽  
Reproductive Toxicity ◽  
Ethanol Extract ◽  
Treated Group ◽  
Male Rats ◽  
Serum Testosterone Level ◽  
Plasma Testosterone ◽  
Daily Ingestion

The aim of the present study was to investigate the toxic effects of aluminum chloride (AlCl3) on the reproductive organs, as well as, the protective effect of propolis against AlCl3-induced reproductive toxicity in male rats. Eighty adult male fertile Sprague Dawley albino rats were randomly divided into four groups of 20 each. Group 1: served as control group and received only distilled water. Group 2: received a daily ingestion of 80 mg/kg of AlCl3. Group 3: received a daily ingestion of 200 mg/kg of an ethanol extract of propolis. Group 4: received a daily ingestion of 80 mg/kg of AlCl3 in addition to 200 mg/kg of an ethanol extract of propolis. The duration of experiment was six weeks. At the end of the experiment, the testes, seminal vesicles, prostate glands and epididymides were dissected out, and weighed. Sperm characteristics were evaluated and plasma testosterone level was estimated. There were no significant changes between the control and the propolis-treated group. AlCl3-treated group showed a highly significant decrease in the index weights of testes and prostate glands, a highly significant lower sperm count, motility and viability, a highly significant increase in the number of abnormal sperms, as well as, a highly significant decrease in serum testosterone level (p < 0.001), compared to control. Rats of AlCl3+propolis-treated group showed a highly significant improvement in all previous alterations. In conclusion, propolis appeared to ameliorate AlCl3-induced reproductive toxicity in male rats.

scholarly journals Protective Effect of Vitamin E on Nicotine Induced Reproductive Toxicity in Male Rats

2015 ◽  
Vol 23 (1) ◽  
pp. 7 ◽  
Author(s):  
WA Oyeyemi ◽  
ST Shittu ◽  
TA Kolawole ◽  
P Ubanecheand ◽  
AO Akinola
Keyword(s):  
Vitamin E ◽  
Protective Effect ◽  
Reproductive Toxicity ◽  
Male Rats

Reproductive toxicity of methomyl insecticide in male rats and protective effect of folic acid

2010 ◽  
Vol 48 (11) ◽  
pp. 3221-3226 ◽  
Author(s):  
M.A. Shalaby ◽  
H.Y. El Zorba ◽  
Reem M. Ziada
Keyword(s):  
Folic Acid ◽  
Protective Effect ◽  
Reproductive Toxicity ◽  
Male Rats

scholarly journals Protective Effect of Propolis against Aluminium Chloride Reproductive Toxicity Histopathological and Ultrastruchtural Study

2020 ◽  
pp. 1-10
Author(s):  
Essam Eldin Abdelhady Salama
Keyword(s):  
Mechanical Properties ◽  
Wound Healing ◽  
Free Radical ◽  
Herpes Simplex ◽  
Protective Effect ◽  
Harmful Effect ◽  
Reproductive Toxicity ◽  
Antimicrobial Properties ◽  
Aluminium Chloride ◽  
Male Rats

Human impact on the environment was steadily increasing the amounts of aluminum in the ecosystems. This element accumulated in plants and water. Potentially increased its harmful effect; particularly, it induced free radical-mediated cytotoxicity and reproductive toxicity. Propolis was a resinous material collected by bees from bud and exudates of the plants, mixed with bee enzymes, pollen, and wax. Due to its waxy nature and mechanical properties, bees used propolis in the construction and repair of their hives, and as a protective barrier against external invaders, or weathering threats, Current antimicrobial properties of propolis, was helping for wound healing, treatment of burns, herpes simplex and genital herpes. The present work studied the protective effect of propolis against the reproductive toxicity of aluminum chloride in male rats.

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