Cysteamine mitigates torsion/detorsion‐induced reperfusion injury via inhibition of apoptosis, oxidative stress and inflammatory responses in experimental rat model

Andrologia ◽  
2021 ◽  
Author(s):  
Oladele Afolabi ◽  
Babatunde Alabi ◽  
Temidayo Omobowale ◽  
Olufemi Oluranti ◽  
Olugbenga Iwalewa
Keyword(s):  
Oxidative Stress ◽  
Reperfusion Injury ◽  
Rat Model ◽  
Inflammatory Responses ◽  
Experimental Rat Model

Aloe vera gel protects liver from oxidative stress-induced damage in experimental rat model

2013 ◽  
Vol 10 (1) ◽  
Author(s):  
Taslima Nahar ◽  
Borhan Uddin ◽  
Shahdat Hossain ◽  
Abdul Mannan Sikder ◽  
Sohel Ahmed
Keyword(s):  
Oxidative Stress ◽  
Rat Model ◽  
Aloe Vera ◽  
Aloe Vera Gel ◽  
Experimental Rat Model

Cytochrome c limits oxidative stress and decreases acidosis in a rat model of hemorrhagic shock and reperfusion injury

2017 ◽  
Vol 82 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Rebecca D. Powell ◽  
Donna A. Goodenow ◽  
Hannah V. Mixer ◽  
Iain H. Mckillop ◽  
Susan L. Evans
Keyword(s):  
Oxidative Stress ◽  
Cytochrome C ◽  
Hemorrhagic Shock ◽  
Reperfusion Injury ◽  
Rat Model

Protective Effect of Mesna on Intestinal Ischemia-reperfusion Injury by Nitric Oxide and Arginase in an Experimental Rat Model

2017 ◽  
Vol 13 (8) ◽  
pp. 1038-1046
Author(s):  
Sanal Filiz ◽  
Ulucam Enis ◽  
Inan Mustafa ◽  
Cerkezkayabekir Aysegul ◽  
Bakar Elvan
Keyword(s):  
Nitric Oxide ◽  
Protective Effect ◽  
Reperfusion Injury ◽  
Rat Model ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Experimental Rat Model ◽  
Intestinal Ischemia Reperfusion

scholarly journals Saikosaponin A-Induced Gut Microbiota Changes Attenuate Severe Acute Pancreatitis through the Activation of Keap1/Nrf2-ARE Antioxidant Signaling

2020 ◽  
Vol 2020 ◽  
pp. 1-19
Author(s):  
Jing Li ◽  
Jinfeng Han ◽  
Juan Lv ◽  
Shiji Wang ◽  
Lai Qu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Pancreatitis ◽  
Gut Microbiota ◽  
Severe Acute Pancreatitis ◽  
Rat Model ◽  
Inflammatory Responses ◽  
Standard Diet ◽  
Microbiota Composition ◽  
Serum Lipase ◽  
Saikosaponin A

Objective. Severe acute pancreatitis (SAP) is a serious and life-threatening disease associated with multiple organ failure and a high mortality rate and is accompanied by distinct oxidative stress and inflammatory responses. Saikosaponin A has strong antioxidant properties and can affect the composition of gut microbiota. We sought to determine the effects of Saikosaponin A interventions on SAP by investigating the changes of gut microbiota and related antioxidant signaling. Methods. A SAP model was established in Sprague-Dawley (SD) rats through the injection of sodium taurocholate into the biliopancreatic duct and confirmed by elevated levels of serum lipase and amylase. The model was fed a standard diet either with saline solution or with Saikosaponin A. Fecal microbiota transplantation (FMT) from Saikosaponin A-induced rats into the rat model was performed to test the effects of gut microbiota. The composition of gut microbiota was analyzed by using 16S rRNA gene sequencing. We measured apoptotic status, inflammatory biomarkers, and Keap1-Nrf2-ARE ((Kelch-like ECH-associated protein 1) nuclear factor erythroid 2-related factor 2-antioxidant response element) antioxidant signaling. Results. Saikosaponin A intervention attenuated SAP lesions and reduced the levels of serum amylase and lipase, oxidative stress, and inflammatory responses by reducing pathological scores and affecting the serum level of oxidative and inflammatory factors. Meanwhile, the expression of Keap1-Nrf2-ARE was increased. Saikosaponin A intervention improved microbiota composition by increasing the relative abundance of Lactobacillus and Prevotella species. FMT resulted in similar results as those caused by the Saikosaponin A intervention, suggesting Saikosaponin A may exert its function via the improvement of gut microbiota composition. Conclusions. Saikosaponin A-induced gut microbiota changes attenuate SAP progression in the rat model and may be a potential natural drug for adjuvant treatment of SAP. Further work is needed to clear up the points.

scholarly journals Erratum to: Effects of everolimus on hepatic ischemia/reperfusion injury in an experimental rat model

2013 ◽  
Vol 45 (3) ◽  
pp. 184-184
Author(s):  
B.G. Demirci ◽  
M. Cindoruk ◽  
U.T. Yilmaz ◽  
M.D. Demirag ◽  
I.I. Gonul ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Rat Model ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Hepatic Ischemia ◽  
Experimental Rat Model ◽  
Hepatic Ischemia Reperfusion

Protective role of chrysin against oxidative stress ind-galactose-induced aging in an experimental rat model

2012 ◽  
Vol 12 (4) ◽  
pp. 741-750 ◽  
Author(s):  
Kalaiselvi Velayutham Anand ◽  
Mohamed Sultan Mohamed Jaabir ◽  
Philip A Thomas ◽  
Pitchairaj Geraldine
Keyword(s):  
Oxidative Stress ◽  
Rat Model ◽  
Protective Role ◽  
Experimental Rat Model
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