Ageing affects plasma steroid concentrations and testicular volume, echotexture and haemodynamics in rams

Andrologia ◽  
2021 ◽  
Author(s):  
Mohamed Hedia ◽  
Amr El‐Shalofy
Keyword(s):  

2007 ◽  
Vol 177 (4S) ◽  
pp. 122-122
Author(s):  
Stephen A. Poon ◽  
G. Joel DeCastro ◽  
Carl K. Gjertson ◽  
Kenneth I. Glassberg


2005 ◽  
Vol 173 (4S) ◽  
pp. 119-119 ◽  
Author(s):  
Gerald Puehse ◽  
Armin Secker ◽  
Sebastian Kemper ◽  
Lothar Hertle ◽  
Sabine Kliesch


Author(s):  
Omer Yumusak ◽  
Mehmet Cinar ◽  
Serkan Kahyaoglu ◽  
Yasemin Tasci ◽  
Gul Nihal Buyuk ◽  
...  

<p><strong>Objective:</strong> Non-obstructive azoospermia, defined as absence of spermatozoa in the ejaculate caused by impaired spermatogenesis, is the most severe cause of male infertility. It is typically presented as high serum follicle stimulating hormone levels and atrophic testis. The combination of intracytoplasmic sperm injection and Microdissection testicular sperm extraction allows these infertile men the opportunity to have their own children from their own testis. Our aim was to evaluate the outcomes of micro-Testicular sperm extraction in men with atrophic testis.</p><p><strong>Study Design:</strong> The medical records of 80 non-obstructive men with azoospermia who underwent micro-TESE were retrospectively evaluated. We assessed clinical parameters; age, duration of infertility, smoking, chromosomal karyotype, Y chromosome microdeletion, follicle stimulating hormone, luteinizing hormone, total testosterone and testicular volume in relation with Microdissection testicular sperm extraction results.</p><p><strong>Results:</strong> Testicular sperm retrieval rate was 53% in 80 patients. Testicular volume, serum follicle stimulating hormone and total testosterone concentrations showed correlation with the results of sperm retrieval. These three parameters were found to be significant risk factors with testicular sperm extraction negative patients (p&lt;0.001). The odds ratios (95% CI) were 6.39 (1.25–26.58), 1.24 (1.11-1.36), 1.13 (0.99-1.21) respectively. Testicular volume was found to be a discriminative parameter in patients with negative sperm retrieval. The cut-off point was established as 6.75 ml for testicular volume with 88.1% sensitivity, 62.1% specificity.</p><p><strong>Conclusion:</strong> Microdissection testicular sperm extraction is the most effective procedure for patients with non-obstructive azoospermia. Testicular volume, serum follicle stimulating hormone and testosterone levels can be predictive factors for sperm retrieval in men with non-obstructive azoospermia.</p>



2006 ◽  
Vol 91 (7) ◽  
pp. 2732-2737 ◽  
Author(s):  
Katharina M. Main ◽  
Jorma Toppari ◽  
Anne-Maarit Suomi ◽  
Marko Kaleva ◽  
Marla Chellakooty ◽  
...  

Abstract Context: Recent studies showed that male reproductive health problems, such as cryptorchidism, hypospadias, testicular cancer, and low sperm quality, are more prevalent in Denmark than in Finland. Objectives: We hypothesized that, if fetal testicular dysgenesis contributed to these observations, differences in gonadal development and the hypothalamus-pituitary-testis axis would already be detectable perinatally. Thus, we investigated healthy newborn boys in both countries. Design: This was a prospective, longitudinal population-based study. Setting: Two primary obstetric centers were included at the University Hospitals of Copenhagen, Denmark, and Turku, Finland. Participants: The participants of the study included 633 Danish and 1044 Finnish boys, born at term with appropriate weight for gestational age. Interventions: Ultrasound determination of testis size at 0, 3, and 18 months and blood sampling (n = 727) at 3 months were analyzed. Main Outcome Measures: Testicular volume and reproductive hormones were measured. Results: Testis volume was significantly higher at all ages in Finnish than in Danish boys (medians, 98 vs. 95, 185 vs. 119, and 188 vs. 136 mm3, respectively; P &lt; 0.00001). Testis growth from birth to 3 months was larger in Finnish than in Danish boys (mean, 75 vs. 26 mm3; P &lt; 0.0001). Serum hormone levels were higher in Finnish than Danish boys for inhibin B (median, 456 vs. 385 pg/ml; P &lt; 0.0001), FSH (1.33 vs. 1.21 IU/liter; P &lt; 0.036), and SHBG (143 vs. 136 nmol/liter; P &lt; 0.022). Inhibin B was significantly positively correlated to testicular volume (r = 0.25; P &lt; 0.006). Conclusions: The larger testes and higher inhibin B levels most likely represent a bigger volume of seminiferous tubules in Finnish compared with Danish boys. Although this phenomenon may be attributable to a genetic difference between the two countries, it may also reflect environmental factors influencing testicular development.



2003 ◽  
Vol 88 (1) ◽  
pp. 179-184 ◽  
Author(s):  
A. M. Mahmoud ◽  
S. Goemaere ◽  
Y. El-Garem ◽  
I. Van Pottelbergh ◽  
F. H. Comhaire ◽  
...  


2009 ◽  
Vol 30 (6) ◽  
pp. 685-689 ◽  
Author(s):  
C.-C. Lin ◽  
W. J. S. Huang ◽  
K.-K. Chen
Keyword(s):  


Urology ◽  
1993 ◽  
Vol 41 (5) ◽  
pp. 466-468 ◽  
Author(s):  
Ihor S. Sawczuk ◽  
Terry W. Hensle ◽  
Kevin A. Burbige ◽  
Harris M. Nagler
Keyword(s):  


2018 ◽  
Vol 21 (6) ◽  
pp. 507-519 ◽  
Author(s):  
Stefano Romagnoli ◽  
Anna Baldan ◽  
Silvia Ferro ◽  
Camilla Righetti ◽  
Ludovico Scenna ◽  
...  

Objectives The objective of this study was to assess duration of efficacy, side effects and return to fertility following use of the 9.4 mg deslorelin implant (Suprelorin 12; Virbac) in cats, and test whether efficacy and duration of action are influenced by implantation site (interscapular vs periumbilical). Methods Sixteen healthy adult tom cats were checked with (1) reproductive examination, (2) gonadotropin-releasing hormone stimulation test and (3) semen collection until achievement of sterility, then with (1) and (2) only at 2, 4, 6 and 12 months, and every 6 months thereafter until treatment effect disappeared. Results Serum testosterone reached basal levels by 7 days post-treatment. Semen quality improved initially then started to worsen by 1 month post-treatment and after 70 days post-treatment all cats were sterile. Early in the third month post-treatment there was a significant decrease in testicular volume and penile spikes. Testicular histology was normal upon neutering performed after resumption of fertility. No injection site lesions or treatment-related side effects were observed. There was no difference between periumbilical and interscapular placement for all criteria, but there was a trend for the decrease in testicular volume to last longer and for the regression of penile spikes to start sooner after interscapular administration. One of 16 cats did not respond to treatment. Six cats were lost at variable times during the study while fully responding to treatment. In the cats that completed the study, normal fertility was regained after 805 days, on average, but with a variable duration of effect from 750–850 days. Conclusions and relevance Treatment with a 9.4 mg deslorelin implant in male cats was effective for a period of 750–850 days, which is 1.5–2 times longer than the effect of the 4.7 mg deslorelin implant. Fertility (based on serum testosterone production and the presence of penile spikes) was regained at the end of the study. Placing implants in the intrascapular vs periumbilical location did not affect duration of suppression of testosterone production. The interscapular location may be characterised by a better efficacy, although further studies are needed to clarify this issue.



Reproduction ◽  
1982 ◽  
Vol 65 (2) ◽  
pp. 439-446 ◽  
Author(s):  
C. M. Howles ◽  
J. Craigon ◽  
N. B. Haynes


2012 ◽  
Vol 52 (5) ◽  
pp. 267
Author(s):  
Rizky Adriansyah ◽  
Muhammad Ali ◽  
Hakimi Hakimi ◽  
Melda Deliana ◽  
Siska Mayasari Lubis

Background Evidence suggests that obesity may be related toearly onset of puberty in girls. However, few studies have found alink between body mass index (BMI) and puberty onset in boys.More study is needed to assess the relationship of BMI to penilelength and testicular volume.Objective To investigate the relationship ofBMI to penile lengthand testicular volume in adolescent boys.Methods A cross􀀿sectional study was carried out on adolescentboys aged 9 to 14 years in Secanggang District, Langkat Regency,North Sumatera Province in August 2009. Subjects' BMIs werecalculated by dividing body weight (BW) in kilograms by bodyheight (BH) in meters squared. Penile length (em) was measuredwith a spatula. We took the average of three measurements fromthe symphysis pubis to the tip of the glans penis. Testicular volume(mL) was estimated by palpation using an orchidometer. Pearson'scorrelation test (r) was used to assess the relationship of BMI topenile length and BMI to testicular volume.Resu lts There were 108 participants, consisting of 64primary school students and 44 junior high school students.Subjects' mean age was 11.7 (SO 1.62) years; mean BWwas 35.2 (SO 8.48) kg; mean BH was 1.4 (SO 0.11) m;mean BMI was 17.5 (SO 2.34) kg/m'; mean penile lengthwas 4.5 (SO 1.25) cm; and mean testicular volume was 3.6(SD 1.20) mL. We found no significant association betweenBMI and penile length (r􀀻-0.25, P􀀻0.06), nor betweenBMI and testicular volume (r􀀻-O.21; P􀀻O.09).Conclusion T here was no significant relationship ofBMI to penilelength nor BMI to testicular volume in adolescent boys.[Paediatr lndanes. 2012;52:267-71].



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