scholarly journals Review article: evidence for the role of gut microbiota in irritable bowel syndrome and its potential influence on therapeutic targets

2014 ◽  
Vol 39 (10) ◽  
pp. 1033-1042 ◽  
Author(s):  
H. L. DuPont
Keyword(s):  
Irritable Bowel Syndrome ◽  
Gut Microbiota ◽  
Therapeutic Targets ◽  
Review Article ◽  
Potential Influence ◽  
Irritable Bowel

scholarly journals Gut Microbiota-Derived Metabolites in Irritable Bowel Syndrome

2021 ◽  
Vol 11 ◽  
Author(s):  
Lin Xiao ◽  
Qin Liu ◽  
Mei Luo ◽  
Lishou Xiong
Keyword(s):  
Amino Acids ◽  
Fatty Acids ◽  
Irritable Bowel Syndrome ◽  
Gut Microbiota ◽  
Short Chain Fatty Acids ◽  
Functional Bowel Disorder ◽  
Irritable Bowel ◽  
The Brain ◽  
Bowel Disorder

Irritable bowel syndrome (IBS) is the most common functional bowel disorder worldwide and is associated with visceral hypersensitivity, gut motility, immunomodulation, gut microbiota alterations, and dysfunction of the brain-gut axis; however, its pathophysiology remains poorly understood. Gut microbiota and its metabolites are proposed as possible etiological factors of IBS. The aim of our study was to investigate specific types of microbiota-derived metabolites, especially bile acids, short-chain fatty acids, vitamins, amino acids, serotonin and hypoxanthine, which are all implicated in the pathogenesis of IBS. Metabolites-focused research has identified multiple microbial targets relevant to IBS patients, important roles of microbiota-derived metabolites in the development of IBS symptoms have been established. Thus, we provide an overview of gut microbiota and their metabolites on the different subtypes of IBS (constipation-predominant IBS-C, diarrhea-predominant IBS-D) and present controversial views regarding the role of microbiota in IBS.

The Role of Acupuncture on the Gut–Brain–Microbiota Axis in Irritable Bowel Syndrome

2021 ◽  
pp. 1-30
Author(s):  
Kiangyada Yaklai ◽  
Sintip Pattanakuhar ◽  
Nipon Chattipakorn ◽  
Siriporn C. Chattipakorn
Keyword(s):  
Irritable Bowel Syndrome ◽  
Gut Microbiota ◽  
Clinical Studies ◽  
Work Productivity ◽  
Action Mechanisms ◽  
Wide Range ◽  
Potential Link ◽  
Irritable Bowel

Irritable bowel syndrome (IBS) is a chronic dysfunction of the gastrointestinal tract, commonly characterized by abdominal pain or abdominal discomfort. These symptoms can substantially reduce the quality of life and work productivity of the patients. The exact pathogenesis of IBS remains unclear, as it has become apparent that multiple pathways are activated in the condition, including inflammation, immunology, neurology and psychology. Recent evidence has shown that symptoms in IBS are related to the dysfunction of the nervous system, particularly the viscerosomatic pathway, through immune-to-brain communication. The potential link between brain–gut relationships is gut microbiota. The management of IBS mostly focuses on symptomatically treating the patients. There are a wide range of standard treatments, including pharmacological to psychological interventions which are effective in some patients. Therefore, a combination of therapies including both standard and complimentary treatments, including Traditional Chinese Medicine (TCM) such as acupuncture, have been used in treating IBS patients. Several in vivo and clinical studies have demonstrated the efficacy of acupuncture in treating IBS. Increasing attention has been paid to research regarding the action mechanisms of acupuncture for IBS. This paper summarizes and discusses the possible mechanisms associated with acupuncture on the pathophysiology of IBS, including gastrointestinal (GI) motility, visceral hypersensitivity, the immune system, neurotransmitters, and the brain–gut axis. The results fromin vivo and clinical studies have been included. In addition, the effects of acupuncture on gut microbiota in IBS are included and any contradictory findings are deliberated.

scholarly journals Irritable bowel syndrome in a patient with obesity: accident or regularity?

2019 ◽  
Vol 2 (13) ◽  
pp. 14-19
Author(s):  
V. I. Simanenkov ◽  
S. V. Tikhonov ◽  
V. D. Dekkanova
Keyword(s):  
Irritable Bowel Syndrome ◽  
Depressive Disorders ◽  
Review Article ◽  
Irritable Bowel

The review article is about the mechanisms of comorbidity of irritable bowel syndrome and obesity. Special attention is paid to the genetic, hormonal mechanisms of comorbidity, the role of anxiety and depressive disorders, the influence of microbiota. Studying the mechanisms of comorbidity may be appropriate in terms of a more detailed study of the pathophysiology and optimization of the treatment of irritable bowel syndrome and obesity and obesity.

Review article: transient receptor potential channels as possible therapeutic targets in irritable bowel syndrome

2017 ◽  
Vol 46 (10) ◽  
pp. 938-952 ◽  
Author(s):  
A. B. Beckers ◽  
Z. Z. R. M. Weerts ◽  
Z. Helyes ◽  
A. A. M. Masclee ◽  
D. Keszthelyi
Keyword(s):  
Irritable Bowel Syndrome ◽  
Transient Receptor Potential ◽  
Therapeutic Targets ◽  
Receptor Potential ◽  
Review Article ◽  
Transient Receptor Potential Channels ◽  
Potential Channels ◽  
Transient Receptor ◽  
Irritable Bowel

scholarly journals Irritable bowel syndrome: a gut microbiota-related disorder?

2017 ◽  
Vol 312 (1) ◽  
pp. G52-G62 ◽  
Author(s):  
Yogesh Bhattarai ◽  
David A. Muniz Pedrogo ◽  
Purna C. Kashyap
Keyword(s):  
Irritable Bowel Syndrome ◽  
Gut Microbiota ◽  
Life Experiences ◽  
Barrier Dysfunction ◽  
Related Disorder ◽  
Next Generation Sequencing Technology ◽  
Irritable Bowel ◽  
Epithelial Barrier Dysfunction ◽  
Connecting The Dots

Irritable bowel syndrome (IBS) is one of the most common gastrointestinal (GI) disorders. Despite its prevalence, the pathophysiology of IBS is not well understood although multiple peripheral and central factors are implicated. Recent studies suggest a role for alterations in gut microbiota in IBS. Significant advances in next-generation sequencing technology and bioinformatics and the declining cost have now allowed us to better investigate the role of gut microbiota in IBS. In the following review, we propose gut microbiota as a unifying factor in the pathophysiology of IBS. We first describe how gut microbiota can be influenced by factors predisposing individuals to IBS such as host genetics, stress, diet, antibiotics, and early life experiences. We then highlight the known effects of gut microbiota on mechanisms implicated in the pathophysiology of IBS including disrupted gut brain axis (GBA), visceral hypersensitivity (VH), altered GI motility, epithelial barrier dysfunction, and immune activation. While there are several gaps in the field that preclude us from connecting the dots to establish causation, we hope this overview will allow us to identify and fill in the voids.

M1682 Intestinal Inflammation and Irritable Bowel Syndrome: An Unexpected Role of the Gut Microbiota

2009 ◽  
Vol 136 (5) ◽  
pp. A-409
Author(s):  
Alain P. Gobert ◽  
Christophe Del'Homme ◽  
Kevin Garraud ◽  
Jean-Louis Kemeny ◽  
Michel C. Dapoigny ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Gut Microbiota ◽  
Intestinal Inflammation ◽  
Irritable Bowel

scholarly journals I. The Role of the Gut Microbiota on Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS)

2015 ◽  
Vol 104 (1) ◽  
pp. 35-41
Author(s):  
Mari Arai ◽  
Katsuyoshi Matsuoka ◽  
Takanori Kanai
Keyword(s):  
Inflammatory Bowel Disease ◽  
Irritable Bowel Syndrome ◽  
Gut Microbiota ◽  
Bowel Disease ◽  
Inflammatory Bowel ◽  
Irritable Bowel

The role of gut microbiota in the treatment of irritable bowel syndrome

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Hamed Ebrahimzadeh Leylabadlo ◽  
Fatemah Sadeghpour Heravi ◽  
Elghar Soltani ◽  
Amin Abbasi ◽  
Hossein Samadi Kafil ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Gut Microbiota ◽  
Irritable Bowel

scholarly journals Targeting the Gut Microbiota to Relieve the Symptoms of Irritable Bowel Syndrome

Pathogens ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1545
Author(s):  
Tomasz Wollny ◽  
Tamara Daniluk ◽  
Ewelina Piktel ◽  
Urszula Wnorowska ◽  
Anna Bukłaha ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Gut Microbiota ◽  
Current Knowledge ◽  
World Population ◽  
Functional Disorder ◽  
The Central Nervous System ◽  
Health And Disease ◽  
Irritable Bowel ◽  
Functional Responsiveness

Irritable bowel syndrome (IBS) is a common, chronic, functional disorder with a large impact on world population. Its pathophysiology is not completely revealed; however, it is certain that dysregulation of the bidirectional communications between the central nervous system (CNS) and the gut leads to motility disturbances, visceral hypersensitivity, and altered CNS processing characterized by differences in brain structure, connectivity and functional responsiveness. Emerging evidence suggests that gut microbiota exerts a marked influence on the host during health and disease. Gut microbiome disturbances can be also important for development of IBS symptoms and its modulation efficiently contributes to the therapy. In this work, we review the current knowledge about the IBS therapy, the role of gut microbiota in pathogenesis of IBS, and we discuss that its targeting may have significant impact on the effectiveness of IBS therapy.

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