The impact of treatment choices on potential drug‐drug interactions in hypertensive patients

2021 ◽  
Author(s):  
Aneta Perić ◽  
Ana Udilović ◽  
Silva Dobrić ◽  
Sandra Vezmar Kovačević
Keyword(s):  
Drug Interactions ◽  
Potential Drug ◽  
Hypertensive Patients ◽  
Treatment Choices ◽  
The Impact

scholarly journals POTENTIAL DRUG INTERACTIONS IN HYPERTENSIVE PATIENTS IN LIWA DISTRICT HOSPITAL, LAMPUNG BARAT, INDONESIA

2017 ◽  
Vol 9 (6) ◽  
pp. 134
Author(s):  
Erna Yanti ◽  
Erna - Kristin ◽  
Alfi Yasmina
Keyword(s):  
Drug Interactions ◽  
District Hospital ◽  
Antihypertensive Agents ◽  
Potential Interaction ◽  
Multiple Drug ◽  
Potential Drug ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Multiple Drugs ◽  
Potential Interactions

Objective: Patients with hypertension often suffer from other comorbidities, resulting in prescriptions of multiple drugs to treat the conditions. Multiple drug treatment is potentially associated with drug interactions. This aim of the study was to assess potential drug interactions in hypertensive patients in Liwa District Hospital.Methods: The design of the study was cross-sectional. The prescriptions for in-patients with essential hypertension in the Internal Medicine Unit in Liwa District Hospital during April-December 2012 were collected. Potential drug interactions were analyzed with the Drug Interaction Facts version 4.0, and classified into minor, significant, and serious.Results: A total of 60 hypertensive patients were included. They were prescribed 265 prescriptions, with a median total of 6 (range 1-21) drugs prescribed per prescription. There were 1616 potential drug interactions, with 6 (1-31) potential interactions per prescription. Most interactions (75.6%) were classified as significant. Serious potential interactions were most common in the combinations of diltiazem-amlodipine and spironolactone-potassium chloride, while significant potential interaction may occur most often with the combinations of calcium chloride-amlodipine and bisoprolol-amlodipine.Conclusion: Numerous potential drug interactions might occur in hypertensive patients, and most interactions were significant in severity. The largest proportion of the interactions occurred between antihypertensive agents and other drugs. 

scholarly journals Polypharmacy in the Management of Arterial Hypertension—Friend or Foe?

Medicina ◽  
2021 ◽  
Vol 57 (12) ◽  
pp. 1288
Author(s):  
Camelia Cristina Diaconu ◽  
Matei-Alexandru Cozma ◽  
Elena-Codruța Dobrică ◽  
Gina Gheorghe ◽  
Alexandra Jichitu ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Chart Review ◽  
Retrospective Chart Review ◽  
Database Search ◽  
Potential Drug ◽  
Hypertensive Patients ◽  
Normotensive Subjects ◽  
The Mean ◽  
Review Study ◽  
Internal Medicine Clinic

Background and Objectives: Polypharmacy is associated with drug–drug or food–drug interactions that may pose treatment difficulties. The objective of the study was to investigate the use of polypharmacy in hypertensive patients hospitalized in the Internal Medicine Clinic of a European referral hospital. Materials and Methods: We conducted a retrospective chart review study on patients identified by a database search of discharge diagnoses to assess the use of polypharmacy and identify potential drug-drug and food-drug interactions. Results: In total, 166 hypertensive patients (68.46 ± 12.70 years, range 42–94 years) were compared to 83 normotensive subjects (67.82 ± 14.47 years, range 22–94 years) who were hospitalized in the clinic during the same period. Polypharmacy was more common in hypertensive versus normotensive subjects (p = 0.007). There were no differences in terms of age, as well as major (0.44 ± 0.77 versus 0.37 ± 0.73 interactions/patient, p = 0.52) and minor (1.25 ± 1.50 versus 1.08 ± 1.84 interactions/patient, p = 0.46) drug–drug interactions between patients with and without hypertension. The mean number of drug–drug interactions (6.55 ± 5.82 versus 4.93 ± 5.59 interactions/patient, p = 0.03), moderate drug–drug interactions (4.94 ± 4.75 versus 3.54 ± 4.17, p = 0.02) and food–drug interactions (2.64 ± 1.29 versus 2.02 ± 1.73, p = 0.00) was higher in patients with hypertension versus their counterparts. Conclusions: The present study reinforces that polypharmacy is a serious concern in hypertensive patients, as reflected by the high number of potentially harmful drug–drug or food–drug interactions. We recorded higher numbers of comorbidities, prescribed drugs, and moderate drug–drug/food–drug interactions in hypertensive versus normotensive patients. A strategy to evaluate the number of discharge medications and reduce drug–drug interactions is essential for the safety of hypertensive patients.

scholarly journals THE CLINICAL SIGNIFICANCE OF POTENTIAL DRUG-DRUG INTERACTIONS AND THEIR TARGETS FOR MINIMIZATION AMONG HYPERTENSIVE DIABETIC OUTPATIENTS AT A KENYAN REFERRAL HOSPITAL

2020 ◽  
pp. 6-11
Author(s):  
MAKITE SIMON LATI ◽  
NYAMU GITONGA DAVID ◽  
ROSALINE NJOKI KINUTHIA
Keyword(s):  
Drug Interaction ◽  
Drug Interactions ◽  
Clinical Significance ◽  
Blood Pressure Monitoring ◽  
Adverse Outcomes ◽  
Potential Drug ◽  
National Hospital ◽  
Hypertensive Patients ◽  
Kenyatta National Hospital ◽  
Arterial Blood

Objective: To characterize the clinical significance of potential drug interactions and identify the targets for their minimization among adult diabetic hypertensive outpatients at Kenyatta National Hospital. Methods: This cross-sectional study collected and analyzed data from 104 diabetic hypertensive outpatients (aged ≥18 y) at the Department of Endocrinology Outpatient Clinic of Kenyatta National Hospital from 1st May 2019 to 31st August 2019. The main outcome measure was the clinical significance of potential drug interactions and the targets for minimization. Participants’ sociodemographic data, drugs prescribed and targets for prevention of potential drug-drug interactions were extracted from patient medical records into predesigned data collection forms. Potential drug interactions were identified using the Micromedex® drug interaction checker. Data was exported to STATA® software version 13 for analysis. Results: The study comprised predominantly females (70.2%) and the mean age was 61.6 (±10.8) years. Over 80% of patients were receiving renin inhibitors or metformin and the commonest potential drug interaction (25.0%) was antidiabetics-beta blockers. The most common potential clinical outcome of the drug-drug interaction was hyperkalemic lactic acidosis (14.4%), induced by combining enalapril with metformin, and hypoglycemia (9.6%) on concomitant use of antidiabetic and beta-blocker. Adverse clinical outcomes were mainly minimized through regular blood sugar checks (100%), blood pressure monitoring (98.1%), and minimal HbA1c (30.8%) checks as well as serum urea and electrolytes (17.3%) measurements. Conclusion: There are potential adverse outcomes of combination pharmacologic therapies among diabetic hypertensive patients in Kenyatta National Hospital. Apart from the clinical monitoring, clinicians should be aware that diabetic hypertensive patients are likely to have serious adverse effects of drug interactions and, therefore, institute or intensify other measures such as arterial blood gases and serum electrolyte tests.

scholarly journals Drug interactions in patients with hypertension at Persahabatan hospital in 2015

2021 ◽  
pp. 309-314
Author(s):  
Zainul Islam ◽  
Atika Vitasari ◽  
Muhammad Arif Ridwan
Keyword(s):  
Drug Interactions ◽  
Medical Records ◽  
Secondary Data ◽  
Sampling Technique ◽  
Descriptive Study ◽  
Retrospective Data ◽  
Potential Drug ◽  
Literature Study ◽  
Hypertensive Disease ◽  
Hypertensive Patients

Introduction: Hypertensive disease can cause various complications, such as cardiovascular disease, stroke, diabetes mellitus, and kidney failure. To overcome these complications, patients are given polypharmacy therapy, which can potentially lead to drug interactions. Aim: The purpose of this study was to determine the potential incidence of drug interactions in hypertensive inpatients at the Persahabatan Hospital in 2015. Methods: The research is a descriptive study with retrospective data by purposive sampling technique using secondary data, medical records of hypertensive inpatients. The study of drug interactions was conducted theoretically, based on a literature study using Drug Interaction Facts 2014. Results: The results showed out of 174 hypertensive patients, 141 (81.0%) had potential drug interactions, with a total of 1444 cases. The highest drug interactions were at three levels of significance in 383 cases (26.5%), with 554 cases (38.4%) of pharmacodynamic mechanisms.

scholarly journals AN ASSESSMENT OF POTENTIAL DRUG-DRUG INTERACTIONS IN HYPERTENSIVE PATIENTS IN A TERTIARY CARE HOSPITAL

2019 ◽  
pp. 32-36
Author(s):  
KAMESWARAN R ◽  
PRAVEEN M. ◽  
KRISHNAVENI KANDASAMY ◽  
SAMBATHKUMAR R.
Keyword(s):  
Drug Interactions ◽  
Prospective Observational Study ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Potential Drug ◽  
Hypertensive Patients ◽  
Hospital Stays

Objective: To an assessment of potential drug-drug interactions in hypertensive patients in a tertiary care hospital. Methods: A prospective, observational study was conducted at a tertiary care hospital, Erode for a period of 8 mo. A sample of 480 patients was assessed for PDDIs using drug checker in Micromedex®-2.7. Results: A total of 430 patients were analyzed and it was found to be 396 (82.50%) hypertensive patients had PDDIs, and a sum total of 1160 PDDIs were observed. Potential drug-drug interactions (PDDIs) higher in female hypertensive patients [255 (64.39%)] compared to males. Incidences of PDDIs were found to be higher in the age group of 60-70 y were [177 (44.69%)] and incidences of interactions based on the duration of (4-6 d) hospital stays were 272 (68.68%). Moreover, 49.24% of patients were found to be prescribed with more than 7 drugs, with higher incidences of PDDIs. Some of the most common drug interacting pair was between aspirin and clopidogrel combination observed in 325 PDDIs in the major, with pharmacodynamics in nature. Conclusion: Clinical pharmacist ought to have the role of regular monitoring of drug therapy in identifying and preventing the medications that have the potential to cause drug-drug interactions, thereby minimizing the undesirable outcomes in drug medical care and improving the quality of care.

OTC Orlistat Poses Potential Drug Interactions

2006 ◽  
Vol 36 (4) ◽  
pp. 8
Author(s):  
ELIZABETH MECHCATIE
Keyword(s):  
Drug Interactions ◽  
Potential Drug

Evaluation of Potential Drug-drug Interactions in the Prescriptions in Outpatient Settings

2020 ◽  
Author(s):  
Seçkin ENGİN ◽  
Elif BARUT ◽  
Feride SEZEN ◽  
Ersin YARIŞ
Keyword(s):  
Drug Interactions ◽  
Potential Drug ◽  
Outpatient Settings
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