scholarly journals Is Nickel Chloride really a Non-Genotoxic Carcinogen?

2016 ◽  
Vol 121 ◽  
pp. 10-15 ◽  
Author(s):  
Leanne Stannard ◽  
Shareen H. Doak ◽  
Ann Doherty ◽  
Gareth J. Jenkins
Keyword(s):  
Nickel Chloride ◽  
Genotoxic Carcinogen

EFFECTS OF NICKEL CHLORIDE ON INDICES OF HEMOCOAGULATION AND LIPID PEROXIDATION IN RATS

2019 ◽  
pp. 83-90
Author(s):  
Э.М. Гаглоева ◽  
В.Б. Брин ◽  
С.В. Скупневский ◽  
Н.В. Боциева ◽  
Т.В. Молдован
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Enzymes ◽  
Platelet Aggregation ◽  
Prothrombin Time ◽  
Partial Thromboplastin Time ◽  
Nickel Chloride ◽  
Activated Partial Thromboplastin Time ◽  
Fibrinogen Concentration ◽  
Thrombin Time ◽  
Hemostasis System

Цель исследования - изучить состояние системы гемостаза при хронической интоксикации хлоридом никеля, исследовать взаимосвязь показателей гемокоагуляции с процессами липопероксидации у крыс в эксперименте. Методика. Опыты проводили на крысах-самцах Вистар (n=50, 230-250 г). Раствор NiCl2 (5 мг/кг) вводили внутрижелудочно ежедневно в течение 2 нед, 1 и 2 мес. По завершении эксперимента исследовали состояние тромбоцитарного и коагуляционного звеньев гемостаза, антикоагулянтную и фибринолитическую активность крови, а также определяли активность процессов перекисного окисления липидов и антиоксидантных ферментов. Результаты. Установлено, что через 2 нед и 1 мес интоксикации у крыс отмечались гиперкоагуляционные изменения показателей свертывающей системы крови: повышение агрегационной активности тромбоцитов, увеличение концентрации фибриногена, снижение активированного частичного тромбопластинового времени (АЧТВ) и протромбинового времени. В этот период регистрировалось увеличение антитромбиновой и фибринолитической активности крови. Через 2 мес наблюдалось подавление активности клеточного звена гемостаза - тромбоцитопения, ослабление степени АДФ-индуцируемой агрегации тромбоцитов. Выявлялась тенденция к уменьшению концентрации фибриногена. На фоне снижения АЧТВ и тромбинового времени отмечалось увеличение протромбинового времени. В то же время регистрировалось угнетение противосвертывающего звена системы гемостаза (снижалась активность антитромбина III), наблюдалось истощение резервных возможностей фибринолитического звена (замедление фXIIа-зависимого эуглобулинового лизиса) и увеличение содержания растворимых фибрин мономерных комплексов, что свидетельствует о наличии тромбинемии. Через 2 нед, один и два месяца интоксикации у животных выявлялись корреляционные связи между основными показателями системы гемостаза и активностью процессов перекисного окисления липидов и антиоксидантных ферментов. Заключение. Полученные данные подтверждают наличие взаимосвязи активности процессов липопероксидации и системы гемостаза, в том числе при хронической никелевой интоксикации. Результаты исследования позволяют рекомендовать применение антиоксидантов для разработки способов коррекции гемостатических сдвигов при воздействии на организм тяжелых металлов. The aim. To study the state of the hemostasis system in chronic nickel intoxication and to investigate the relationship between hemocoagulation indices and lipoperoxidation processes in rats. Methods. Experiments were carried out on male Wistar rats (n=50, 230-250 g). A solution of nickel chloride (5 mg/kg) was administered daily intragastrically for two weeks, one and two months. At the end of the experiments, indices of platelet and coagulation hemostasis systems, anticoagulant and fibrinolytic activity of blood plasma, and activities of lipid peroxidation and antioxidant enzymes were studied. Results. Hypercoagulative changes in indices of the coagulation system were observed in rats after two weeks and one month of intoxication, including increased platelet aggregation and fibrinogen concentration and shortened activated partial thromboplastin time and prothrombin time. During the same period, increased antithrombin and fibrinolytic activities were observed. The depressed activity of the cellular component of hemostasis evident as thrombocytopenia and impaired ADP-induced platelet aggregation was detected after two months of intoxication. A tendency to decrease in fibrinogen concentration was observed. The shortened activated partial thromboplastin time and thrombin time were associated with prolonged prothrombin time. At the same time, inhibition of the anticoagulant component of hemostasis (decreased antithrombin III activity), exhaustion of the fibrinolysis system reserve (delayed fXIIa-dependent euglobulin lysis), and a significant increase in soluble fibrin monomeric complexes indicative of thrombinemia were observed. After two weeks, one and two months of nickel intoxication, a correlation was found between the major indices of the hemostasis system and the activities of lipid peroxidation and antioxidant enzymes. Conclusion. The study confirmed a relationship between the lipid peroxidation activity and the hemostasis system, specifically in chronic nickel intoxication. This result allows to recommend the use of antioxidants in developing methods for correction of hemostatic induced affected by heavy metals.

Exploring the characterization of Ni doped MgO nanoparticles using co-precipitation method

2020 ◽  
Vol 3 (1) ◽  
pp. 30-33
Author(s):  
Muthulakshmi M ◽  
Madhumitha G
Keyword(s):  
Magnesium Oxide ◽  
Analytical Techniques ◽  
Nickel Chloride ◽  
Precipitation Method ◽  
Crystalline Powder ◽  
High Melting Point ◽  
Design Synthesis ◽  
Mgo Nanoparticles ◽  
Co Precipitation

Nanotechnology is a field of applied science focused on design, synthesis and characterization of nanomaterials. The nickel and magnesium have improved their applications in transparent electrodes and nano electronics. In addition, magnesium oxide has moisture resistance and high melting point properties. In the present work has been carried out in the development of green crystalline powder of nickel doped magnesium oxide nanoparticles by Co-precipitation method, from the mixture of nickel chloride and magnesium chloride with KOH as solvent. From the XRD results, crystalline size of the particle can be observed. Spherical structure of Ni doped MgO nanoparticles were indicated by SEM results and powdered composition of samples were obtained from FTIR. EDAX represents the peak composition of the nanoparticle. The above analytical techniques have confirmed that the Ni doped MgO nanoparticles obtained from the mixture of NiCl2 and MgCl2.

Studies about Electrochemical Plating with Zinc - nickel Alloys - the Influence of Deposition Potential on Stoichiometric Composition

2008 ◽  
Vol 59 (9) ◽  
Author(s):  
Violeta Vasilache ◽  
Gheorghe Gutt ◽  
Traian Vasilache
Keyword(s):  
Nickel Alloys ◽  
Stoichiometric Composition ◽  
Nickel Chloride ◽  
Deposition Potential ◽  
X Ray Diffraction ◽  
Pure Zinc ◽  
X Ray ◽  
Nickel Cobalt ◽  
Cobalt Iron ◽  
Electrochemical Plating

The electrochemical deposition of zinc and combinations with elements of the 8th group of the Periodic System (nickel, cobalt, iron) have good properties for anticorrosive protection, compared with pure zinc. For steel pieces, these films delay apparition and formation of white and red iron oxide. We used solutions with different concentrations of zinc chloride, nickel chloride and potassium chloride. To analyze the results we used the optic microscope and the X-ray diffraction.

scholarly journals Ethanol extract of Nigella sativa has antioxidant and ameliorative effect against nickel chloride-induced hepato-renal injury in rats

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Kazeem Akinyinka Akinwumi ◽  
Afusat Jagun Jubril ◽  
Oreoluwa Oluwafunke Olaniyan ◽  
Yusuf Yusuf Umar
Keyword(s):  
Renal Injury ◽  
Nigella Sativa ◽  
Ethanol Extract ◽  
Nickel Chloride ◽  
Ameliorative Effect

scholarly journals Surface-Enhanced Infrared Absorption of o-Nitroaniline on Nickel Nanoparticles Synthesized by Electrochemical Deposition

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Yufang Niu ◽  
Jie Yao ◽  
Keyu Wang
Keyword(s):  
Infrared Absorption ◽  
Indium Tin Oxide ◽  
Nickel Nanoparticles ◽  
Ph Value ◽  
Glass Plate ◽  
Nickel Sulfate ◽  
Nickel Chloride ◽  
Attenuated Total Reflection ◽  
Enhancement Effect ◽  
Surface Enhanced

Nickel nanoparticles were electrochemically deposited on indium-tin oxide (ITO) coated glass plate in a modified Watt’s electrolyte. The surface-enhanced infrared absorption (SEIRA) effect of the nanoparticles was evaluated by attenuated total reflection spectroscopy (ATR-FTIR) using o-nitroaniline as a probe molecule. Electrodeposition parameters such as deposition time, pH value, and the type of surfactants were investigated. The morphology and the microstructure of the deposits were characterized by the field emission scanning electron microscope (FESEM) and the atomic force microscope (AFM), respectively. The results indicate that the optimum parameters were potential of 1.3 V, time of 30 s, and pH of 8.92 in the solution of 0.3756 mol/L diethanolamine, 0.1 mol/L nickel sulfate, 0.01 mol/L nickel chloride, and 0.05 mol/L boric acid. The FESEM observation shows that the morphology of nickel nanoparticles with best enhancement effect is spherical and narrowly distributed particles with the average size of 50 nm. SEIRA enhancement factor is about 68.

Nickel chloride/chlorides of divalent metal interactions in nickel-sensitive subjects

1996 ◽  
Vol 5 (5) ◽  
pp. 254-259 ◽  
Author(s):  
B. Santucci ◽  
C. Cannistraci ◽  
A. Cristaudo ◽  
M. Picardo
Keyword(s):  
Nickel Chloride ◽  
Divalent Metal ◽  
Metal Interactions

X‐ray study of Kr and Xe adsorbed on the basal plane of nickel chloride

1988 ◽  
Vol 88 (1) ◽  
pp. 451-456 ◽  
Author(s):  
K. Morishige ◽  
M. Hanayama ◽  
S. Kittaka
Keyword(s):  
Basal Plane ◽  
Nickel Chloride ◽  
X Ray

Free radicals-mediated induction of oxidized DNA bases and DNA−protein cross-links by nickel chloride

2002 ◽  
Vol 514 (1-2) ◽  
pp. 233-243 ◽  
Author(s):  
Katarzyna Woźniak ◽  
Janusz Błasiak
Keyword(s):  
Free Radicals ◽  
Nickel Chloride ◽  
Dna Bases ◽  
Cross Links
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