The serotonin transporter genotype modulates the relationship between early stress and adult suicidality in bipolar disorder

AbstractSLC6A4, which encodes the serotonin transporter, has a functional polymorphism called the serotonin transporter-linked polymorphic region (5-HTTLPR). The 5-HTTLPR consists of short (S) and long (L) alleles, each of which has 14 or 16 tandem repeats. In addition, the extralong (XL) and other rare alleles have been reported in 5-HTTLPR. Although they are more frequent in Asian and African than in other populations, the extent of variations and allele frequencies (AFs) were not addressed in a large population. Here, we report the AFs of the rare alleles in a large number of Japanese subjects (N = 2894) consisting of two cohorts. The first cohort (case-control study set, CCSS) consisted of 1366 subjects, including 485 controls and 881 patients with psychosis (bipolar disorder or schizophrenia). The second cohort (the Arao cohort study set, ACSS) consisted of 1528 elderly subjects. During genotyping, we identified 11 novel 5-HTTLPR alleles, including 3 XL alleles. One novel allele had the longest subunit ever reported, consisting of 28 tandem repeats. We named this XL28-A. An in vitro luciferase assay revealed that XL28-A has no transcriptional activity. XL28-A was found in two unrelated patients with bipolar disorder in the CCSS and one healthy subject in the ACSS who did not show depressive symptoms or a decline in cognitive function. Therefore, it is unlikely that XL28-A is associated with psychiatric disorders, despite its apparent functional deficit. Our results suggest that unraveling the complex genetic variations of 5-HTTLPR will be important for further understanding its role in psychiatric disorders.

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Parent of origin effect and allelic expression imbalance of the serotonin transporter in bipolar disorder and suicidal behaviour

European Archives of Psychiatry and Clinical Neuroscience ◽

10.1007/s00406-011-0192-8 ◽

2011 ◽

Vol 261 (8) ◽

pp. 533-538 ◽

Cited By ~ 14

Author(s):

Crystal Pinto ◽

Renan P. Souza ◽

Diane Lioult ◽

Mawahib Semeralul ◽

James L. Kennedy ◽

...

Keyword(s):

Bipolar Disorder ◽

Serotonin Transporter ◽

Suicidal Behaviour ◽

Allelic Expression ◽

Allelic Expression Imbalance ◽

Parent Of Origin ◽

Origin Effect

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Alcohol use and bipolar disorder comorbidity: Synthesis and perspectives

European Psychiatry ◽

10.1016/j.eurpsy.2017.01.535 ◽

2017 ◽

Vol 41 (S1) ◽

pp. S470-S470

Author(s):

A. Dahdouh ◽

B. Semaoune ◽

A. Tremey ◽

L. Samalin ◽

V. Flaudias ◽

...

Keyword(s):

Bipolar Disorder ◽

Alcohol Use ◽

Dual Diagnosis ◽

Public Health Problem ◽

Major Public Health Problem ◽

Systematic Screening ◽

Electronic Search ◽

Clinical Interest ◽

Competing Interest ◽

The Relationship

ObjectiveAlcohol use disorders and bipolar disorder commonly co-occur and both are associated with more pejorative outcomes, thus constituting a major public health problem. We undertook this synthetic review to provide an update on this issue in order to clarify the nature of the relationship between the two disorders, improve clinical outcomes, prevent complications and therefore optimize management of patients.MethodsWe conducted an electronic search by keywords in databases MEDLINE, EMBASE, PsychINFO, published in English and French from January1985 to December 2015.ResultsThe AUD prevalence is important among BD patients in whom the effects of alcohol are more severe. However, in terms of screening, it appears that the comorbidity is not systematically sought. The concept of co-occurrence finds its clinical interest in the development of specific screening and therapeutic strategies. To date, there are only few recommendations about the management of dual diagnosis and the majority of them support “integrated” approaches.ConclusionsRecommendations should emphasize this strong co-occurrence and promote systematic screening and offered integrated cares.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Associations between residual depressive symptoms, cognition, and functioning in patients with euthymic bipolar disorder: results from the FACE-BD cohort

The British Journal of Psychiatry ◽

10.1192/bjp.bp.117.201335 ◽

2017 ◽

Vol 211 (6) ◽

pp. 381-387 ◽

Cited By ~ 18

Author(s):

Paul Roux ◽

Aurélie Raust ◽

Anne-Sophie Cannavo ◽

Valérie Aubin ◽

Bruno Aouizerate ◽

...

Keyword(s):

Bipolar Disorder ◽

Depressive Symptoms ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Cognitive Component ◽

Cognitive Components ◽

The Face ◽

Sources Of Variation ◽

The Relationship

BackgroundThe relationship between residual depressive symptoms, cognition and functioning in patients with euthymic bipolar disorder is a subject of debate.AimsTo assess whether cognition mediates the association between residual depressive symptoms and functioning in patients with bipolar disorder who were euthymic.MethodWe included 241 adults with euthymic bipolar disorder in a multicentre cross-sectional study. We used a battery of tests to assess six cognition domains. A path analysis was then used to perform a mediation analysis of the relationship between residual depressive symptoms, cognitive components and functioning.ResultsOnly verbal and working memory were significantly associated with better functioning. Residual depressive symptoms were associated with poorer functioning. No significant relationship was found between residual depressive symptoms and any cognitive component.ConclusionsCognition and residual depressive symptoms appear to be two independent sources of variation in the functioning of people with euthymic bipolar disorder.

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Resting-state cerebral blood flow in amygdala is modulated by sex and serotonin transporter genotype

NeuroImage ◽

10.1016/j.neuroimage.2013.03.003 ◽

2013 ◽

Vol 76 ◽

pp. 90-97 ◽

Cited By ~ 10

Author(s):

W. El-Hage ◽

F. Zelaya ◽

J. Radua ◽

B. Gohier ◽

D.C. Alsop ◽

...

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Serotonin Transporter ◽

Resting State ◽

Serotonin Transporter Genotype

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STAGE PERSONA, STAND-UP COMEDY AND MENTAL HEALTH: ‘PUTTING YOURSELF OUT THERE’

Persona Studies ◽

10.21153/psj2019vol5no2art917 ◽

2020 ◽

Vol 5 (2) ◽

pp. 67-82

Author(s):

MATT HARGRAVE

Keyword(s):

Mental Health ◽

Bipolar Disorder ◽

Mental Illness ◽

Depression And Anxiety ◽

Stand Up Comedy ◽

The Subject ◽

The Relationship

This article addresses the subject of stand-up and mental health through the prism of comic persona, generating new, non-diagnostic discourses around mental illness. The article focuses on British and Australian comedians whose material addresses conditions such as bipolar disorder (John Scott), depression and anxiety (Seymour Mace; Lauren Pattison; Felicity Ward), or feigns the staging of mental collapse (Stewart Lee). Based on the analysis of live events and one-on-one interviews, the essay considers the role that persona plays in mediating the relationship between the comedian and their material, arguing that shaping persona is key to developing practices framed within a poetics of vulnerability.

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