Genome‐wide scan for structural variation underlying psoriasis

2021 ◽  
Author(s):  
N. Dand
Keyword(s):  
Structural Variation ◽  
Genome Wide ◽  
Genome Wide Scan

Genome-wide scan for modifier genes of liver fibrosis in Abcb4/Mdr2 deficient mice

2009 ◽  
Vol 47 (01) ◽  
Author(s):  
F Grünhage ◽  
K Hochrath ◽  
R Hall ◽  
F Lammert
Keyword(s):  
Liver Fibrosis ◽  
Modifier Genes ◽  
Genome Wide ◽  
Deficient Mice ◽  
Genome Wide Scan

P6017 A high density genome-wide scan for genetic risk factors of insect bite hypersensitivity (IBH): A Horsegene Project Initiative

2016 ◽  
Vol 94 (suppl_4) ◽  
pp. 156-157
Author(s):  
B. D. Velie ◽  
M. Shrestha ◽  
L. Francois ◽  
A. Schurink ◽  
A. Stinckens ◽  
...  
Keyword(s):  
Risk Factors ◽  
Genetic Risk ◽  
Genetic Risk Factors ◽  
High Density ◽  
Genome Wide ◽  
Insect Bite Hypersensitivity ◽  
Genome Wide Scan

scholarly journals Genome-wide Scan of IQ Finds Significant Linkage to a Quantitative Trait Locus on 2q

2005 ◽  
Vol 36 (1) ◽  
pp. 45-55 ◽  
Author(s):  
M. Luciano ◽  
M. J. Wright ◽  
D. L. Duffy ◽  
M. A. Wainwright ◽  
G. Zhu ◽  
...  
Keyword(s):  
Quantitative Trait Locus ◽  
Quantitative Trait ◽  
Genome Wide ◽  
Trait Locus ◽  
Significant Linkage ◽  
Genome Wide Scan

A genomewide study of body mass index and its genetic correlation with thromboembolic risk

2014 ◽  
Vol 112 (11) ◽  
pp. 1036-1043 ◽  
Author(s):  
Geórgia Pena ◽  
Andrey Ziyatdinov ◽  
Alfonso Buil ◽  
Sonia López ◽  
Jordi Fontcuberta ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Genetic Correlation ◽  
Body Mass ◽  
Thromboembolic Disease ◽  
Thromboembolic Risk ◽  
Genetic Components ◽  
Genome Wide ◽  
Thrombosis Risk ◽  
Bivariate Linkage Analysis ◽  
Genome Wide Scan

SummaryThrombosis and obesity are complex epidemiologically associated diseases. The mechanism of this association is not yet understood. It was the objective of this study to identify genetic components of body mass index (BMI) and their possible role in the risk of thromboembolic disease. With the self-reported BMI of 397 individuals from 21 extended families enrolled in the GAIT (Genetic Analysis of Idiopathic Thrombophilia) Project, we estimated the heritability of BMI and the genetic correlation with the risk of thrombosis. Subjects were genotyped for an autosomal genome-wide scan with 363 highly-informative DNA markers. Univariate and bivariate multipoint linkage analyses were performed. The heritability for BMI was 0.31 (p= 2.9×10–5). Thromboembolic disease (including venous and arterial) and BMI had a significant genetic correlation (ρG= 0.54, p= 0.005). Two linkage signals for BMI were obtained, one at 13q34 (LOD= 3.36, p= 0.0004) and other at 2q34, highly suggestive of linkage (LOD= 1.95). Bivariate linkage analysis with BMI and thrombosis risk also showed a significant signal at 13q34 (LOD= 3), indicating that this locus influences at the same time normal variation in the BMI phenotype as well as susceptibility to thrombosis. In conclusion, BMI and thrombosis are genetically correlated. The locus 13q34, which showed pleiotropy with both phenotypes, contains two candidate genes, which may explain our linkage pleiotropic signal and deserve further investigation as possible risk factors for obesity and thrombosis.

scholarly journals Genome-wide scan identifies a copy number variable region at 3p21.1 that influences the TLR9 expression levels in IgA nephropathy patients

2014 ◽  
Vol 23 (7) ◽  
pp. 940-948 ◽  
Author(s):  
Fabio Sallustio ◽  
◽  
Sharon N Cox ◽  
Grazia Serino ◽  
Claudia Curci ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Copy Number ◽  
Variable Region ◽  
Expression Levels ◽  
Tlr9 Expression ◽  
Copy Number Variable Region ◽  
Genome Wide ◽  
Genome Wide Scan

A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia

2006 ◽  
Vol 38 (7) ◽  
pp. 794-800 ◽  
Author(s):  
Anelia Horvath ◽  
Sosipatros Boikos ◽  
Christoforos Giatzakis ◽  
Audrey Robinson-White ◽  
Lionel Groussin ◽  
...  
Keyword(s):  
Gene Encoding ◽  
Genome Wide ◽  
A Genome ◽  
Adrenocortical Hyperplasia ◽  
Genome Wide Scan

Genome-wide scan on total serum IgE levels identifies no common variants in a healthy Chinese male population

2013 ◽  
Vol 65 (8) ◽  
pp. 561-568 ◽  
Author(s):  
Ming Liao ◽  
Dianchun Shi ◽  
Yao Wang ◽  
Kai Zhang ◽  
Xin Chen ◽  
...  
Keyword(s):  
Total Serum ◽  
Common Variants ◽  
Male Population ◽  
Serum Ige ◽  
Genome Wide ◽  
Healthy Chinese ◽  
Chinese Male ◽  
Genome Wide Scan
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