Design and development of novel fasudil derivatives as potent anti‐breast cancer agent that improves intestinal flora and intestinal barrier function in rats

2021 ◽  
Author(s):  
Jinghui Liang ◽  
Mu Tang ◽  
Lieliang Wang ◽  
Rui Huang ◽  
Ailong Fu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Barrier Function ◽  
Intestinal Flora ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Design And Development ◽  
Cancer Agent

The effect of fucoidan on intestinal flora and intestinal barrier function in rats with breast cancer

2018 ◽  
Vol 9 (2) ◽  
pp. 1214-1223 ◽  
Author(s):  
Meilan Xue ◽  
Xinqiang Ji ◽  
Hui Liang ◽  
Ying Liu ◽  
Bing Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Barrier Function ◽  
Intestinal Flora ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Prevention Of Breast Cancer

Fucoidan could be used as an intestinal flora modulator for potential prevention of breast cancer.

Endogenous intoxication syndrome in pyelonephritis and methods of its therapy with the use of nutrient support

2021 ◽  
pp. 40-45
Author(s):  
G. M. Letifov
Keyword(s):  
Barrier Function ◽  
Nutritional Support ◽  
Intestinal Flora ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Antibacterial Prophylaxis ◽  
Urinary System ◽  
Dietary Fibers ◽  
Endogenous Intoxication ◽  
Medical University

Endogenous intoxication syndrome in pyelonephritis and methods of its therapy using nutritional support G.M. Letifov FSBEI HE «Rostov State Medical University Ministry of Health of Russia Rostov-on-Don Summary The aim of the study was to scientifically substantiate and determine the prospects for the use of nutritional support in the form of the use of dietary supplements containing a complex of natural dietary fibers, inulin (from artichoke), effective probiotics-short-chain fructooligosaccharides, maltodextrin 1.5 teaspoon 2 times a day. The course of treatment is 3 weeks. The appointment of a prebiotic complex, prevention of dysbiosis and restoration of the intestinal barrier function significantly reduced the risk of re-entry of opportunistic intestinal flora into the urinary system, thereby reducing the need for antibacterial prophylaxis of recurrent pyelonephritis.

scholarly journals The effects of fluorouracil, epirubicin, and cyclophosphamide (FEC60) on the intestinal barrier function and gut peptides in breast cancer patients: an observational study

BMC Cancer ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Francesco Russo ◽  
Michele Linsalata ◽  
Caterina Clemente ◽  
Benedetta D’Attoma ◽  
Antonella Orlando ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Observational Study ◽  
Cancer Patients ◽  
Barrier Function ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Breast Cancer Patients ◽  
Gut Peptides

scholarly journals Luhong Granules Prevent Ventricular Remodelling after Myocardial Infarction by Reducing the Metabolites TMAO and LPS of the Intestinal Flora

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Tianshu Yang ◽  
Huiyan Qu ◽  
Xiaolong Song ◽  
Qian Liu ◽  
Xiaoli Yang ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Barrier Function ◽  
Intestinal Flora ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Sham Operation ◽  
Plasma Samples ◽  
Ventricular Remodelling ◽  
Sham Operation Group ◽  
Operation Group

Background. Ventricular remodelling is a common pathological change at all stages of heart disease. Luhong granules are widely used in patients with chronic ventricular remodelling after myocardial infarction and can alleviate chest tightness, shortness of breath, and other symptoms. However, its effect on ventricular remodelling remains to be studied. Purpose. In this study, we investigated the effects of these granules on myocardial fibrosis in a rat model of myocardial infarction in vivo. Methods. Male Wistar rats were randomly divided into four groups: the sham operation group, the acute myocardial infarction (AMI) group, the Luhong granule group, and the vancomycin group, with a sample size (n) of 10 rats in each group. The AMI model was established in all rats by ligation of the left anterior descending (LAD) coronary artery (the sham operation group did not undergo ligation). Luhong granules (0.5 ml·kg−1·d−1), vancomycin (0.075 g·ml−1·d−1), and 0.9% saline (5 ml·kg−1·d−1 for the sham operation and AMI groups) were administered orally for 6 weeks. Echocardiography was used to check cardiac structure and function. Myocardial and small intestinal tissue morphology was observed by haematoxylin and eosin (H&E) staining, and heart samples were stained with Masson’s trichrome to analyse myocardial fibrosis. 16S rDNA sequencing was performed to detect changes in the gut flora. The level of trimethylamine N-oxide (TMAO) in plasma samples was quantified by stable isotope dilution liquid chromatography-tandem mass spectrometry (LC-MS). Results. H&E and Masson’s trichrome staining of cardiac tissues showed that Luhong granules could partially reverse ventricular remodelling and improve intestinal barrier function (P<0.05). Echocardiographic analysis showed that, compared with the AMI group, the left ventricular ejection fraction (LVEF) in the Luhong granule group was increased (P<0.05). Stool sequencing and microbiological analysis showed changes in Bacteroidales, Alistipes, Phascolarctobacterium, etc., which can produce TMAO. We found that Luhong granules can reduce Bacteroidales, Alistipes, and Phascolarctobacterium at the genus level. The levels of TMAO and lipopolysaccharides (LPS) in plasma samples were reduced in the Luhong granule group (P<0.05). Conclusions. Our results indicate that Luhong granules reduce TMAO and LPS levels in circulating blood by improving intestinal flora and intestinal barrier function to delay ventricular remodelling after myocardial infarction.

scholarly journals Mode of Action of Dietary Dexamethasone May Not Be Dependent Upon Microbial Mechanisms in Broilers

2019 ◽  
Vol 7 (9) ◽  
pp. 346
Author(s):  
Audrey F. Duff ◽  
Mikayla F. A. Baxter ◽  
B. Danielle Graham ◽  
Billy M. Hargis ◽  
Lisa R. Bielke
Keyword(s):  
Barrier Function ◽  
Mode Of Action ◽  
Intestinal Flora ◽  
Intestinal Barrier ◽  
Fluorescein Isothiocyanate ◽  
Intestinal Barrier Function ◽  
Intestinal Microbes ◽  
Opportunistic Disease ◽  
Microbial Profile ◽  
Gut Barrier Function

Dexamethasone (Dex), a synthetic glucocorticoid (GC), in feed has been shown to increase gut permeability via stress-mediated mechanisms, but the exact mode of action on gut barrier function is not fully understood. Stress has been reported to alter the profile and virulence of intestinal flora predisposing for opportunistic disease. This study aimed to evaluate the relationship between dietary Dex and recoverable intestinal microbial profile in broilers to better understand mode of action and refine future uses of the model. Three experiments were conducted that administered Dex-treated feed for one week in conjunction with the antibiotics BMD (bacitracin methylene disalicylate) or Baytril® (enrofloxacin) to evaluate if enteric microbial mechanisms were important in Dex-induced permeability. Serum fluorescein isothiocyanate-dextran (FITC-d) and bacterial translocation (BT) have been reported to increase after Dex treatment and were used to assess gut epithelial leakage. Shifts in bacterial profiles were also measured on selective agar. Combining Dex with BMD or Baytril resulted in increased (P < 0.05) serum FITC-d versus Dex-only. Additionally, Baytril did not reduce aerobic BT and bacterial profiles remained similar after Dex. These results suggest a minimal role of intestinal microbes in Dex-induced changes to intestinal barrier function.

scholarly journals Effect of Fermented Traditional Chinese Prescription With Lactobacillus Plantarum on Dysbacteriotic Diarrhea Mice Induced by Ceftriaxone Sodium

2021 ◽  
Author(s):  
Xin Guo ◽  
Zipeng Yan ◽  
Jixiang Wang ◽  
Xinfeng Fan ◽  
Jie Kang ◽  
...  
Keyword(s):  
Lactobacillus Plantarum ◽  
Barrier Function ◽  
High Performance ◽  
Intestinal Flora ◽  
Intestinal Barrier ◽  
Intestinal Morphology ◽  
Intestinal Barrier Function ◽  
Flight Mass Spectrometry ◽  
Ceftriaxone Sodium ◽  
Fecal Output

Abstract Background: Buzhongyiqi decoction (B), Sijunzi decoction (S), and Shenlingbaizhu decoction (SH) have been extensively clinically used for the treatment of health status and diseases caused by spleen-qi deficiency for many years and microbial fermentation has been widely applied in Traditional Chinese Medicine (TCM) for thousands of years in China. This study was aimed to investigate the mitigative effect of TCM and fermented TCM (FTCM) with Lactobacillus plantarum (LP) in antibiotic-associated diarrhea (AAD), and identify the compounds of S and Fermented S (FS). Methods: The dysbacteriotic diarrhea mice induced by ceftriaxone sodium (CS) were treated with LP, B, S, SH, Fermented B, S, and SH. The diarrhea indexes, the abundance of some gut bacteria, intestinal morphometrics, and the mRNA expressions related to intestinal barrier function were assessed at multilevels. In addition, S and FS were chosen to identify and relatively quantify the compounds by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF/MS), and different expressed compounds were analysed. Results: Results showed that CS significantly increased the fecal output weight, the total number of fecal output, and fecal water content, indicating the occurrence of diarrhea, while TCM, LP, and FTCM alleviated the diarrhea to different degrees and FTCM showed more sustained effects. Then, bacterial culture test showed above symptoms were accompanied with the disruption of some intestinal flora. Meanwhile, the diarrhea mice showed abnormal intestinal morphology and destroyed intestinal barrier manifested as reduced mRNA expression of Aquaporins (AQPs) and tight junction (TJ) protein. Notably, the above indices were alleviated in other treatments mice.Conclusions: All these findings imply that the intestinal side effects caused by antibiotics can be alleviated by TCM, LP, and fermented TCM through regulating the intestinal flora and barrier function, which provides an idea of further development and application of them in the clinical use of antibiotics.

Protein kinase C (PKC)-β1 mediates EGF-induced protection of the microtubule (MT) cytoskeleton & intestinal barrier function (BF) against oxidant injury

2001 ◽  
Vol 120 (5) ◽  
pp. A701-A701
Author(s):  
A BANAN ◽  
J FIELDS ◽  
Y ZHANG ◽  
E MUTLU ◽  
A KESHAVARZIAN
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Barrier Function ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Oxidant Injury ◽  
Kinase C
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