scholarly journals Characterization of circulating immune cells in acute Kawasaki disease suggests exposure to different antigens

2020 ◽  
Vol 202 (3) ◽  
pp. 263-272
Author(s):  
J. C. Burns ◽  
L. E. Hsieh ◽  
J. Kumar ◽  
N. Behnamfar ◽  
C. Shimizu ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Immune Cells ◽  
Acute Kawasaki Disease

scholarly journals Memory T-cells and characterization of peripheral T-cell clones in acute Kawasaki disease

Autoimmunity ◽  
2010 ◽  
Vol 43 (4) ◽  
pp. 317-324 ◽  
Author(s):  
Alessandra Franco ◽  
Chisato Shimizu ◽  
Adriana H. Tremoulet ◽  
Jane C. Burns
Keyword(s):  
T Cells ◽  
T Cell ◽  
Kawasaki Disease ◽  
Memory T Cells ◽  
T Cell Clones ◽  
Cell Clones ◽  
Acute Kawasaki Disease

Efficacy of Intravenous Immunoglobulin Combined with Prednisolone Following Resistance to Initial Intravenous Immunoglobulin Treatment of Acute Kawasaki Disease

2013 ◽  
Vol 163 (2) ◽  
pp. 521-526.e1 ◽  
Author(s):  
Tohru Kobayashi ◽  
Tomio Kobayashi ◽  
Akihiro Morikawa ◽  
Kentaro Ikeda ◽  
Mitsuru Seki ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Intravenous Immunoglobulin ◽  
Acute Kawasaki Disease ◽  
Immunoglobulin Treatment

Therapy of acute Kawasaki disease

1991 ◽  
Vol 1 (3) ◽  
pp. 254-255
Author(s):  
Jane W. Newburger
Keyword(s):  
Myocardial Infarction ◽  
Early Childhood ◽  
Kawasaki Disease ◽  
Sudden Death ◽  
Cervical Lymphadenopathy ◽  
Unknown Etiology ◽  
Acute Kawasaki Disease ◽  
Arterial Insufficiency ◽  
Infancy And Early Childhood ◽  
Arterial Aneurysms

Kawasaki disease is an acute vasculitis of unknown etiology that occurs predominantly in infancy and early childhood. It is characterize by fever, bilateral nonexudative conjunctivitis, erythema of the lips and oral mucosa, changes in the extremities, rash, and cervical lymphadenopathy.1,2 Coronary arterial aneurysms, or ectasia, develop in approximately 15 to 25% of children with the disease, and may lead to myocardial infarction, sudden death, or chronic coronary arterial insufficiency.2–4

Characterization of the immunomodulatory effect in vitro of microvesicles isolated from mesenchymal stromal cells on immune cells

2013 ◽  
Vol 41 (8) ◽  
pp. S64
Author(s):  
Antonella Conforti ◽  
Marco Scarsella ◽  
Ezio Giorda ◽  
Simone Biagini ◽  
Nadia Starc ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Immune Cells ◽  
Stromal Cells ◽  
Immunomodulatory Effect

scholarly journals Gatekeepers of the fetus: Characterization of placental macrophages

2020 ◽  
Vol 218 (1) ◽  
Author(s):  
Christina Megli ◽  
Carolyn B. Coyne
Keyword(s):  
Immune Cells ◽  
Depth Analysis ◽  
Hofbauer Cells ◽  
Placental Macrophages ◽  
Maternal Fetal Interface

In this issue of JEM, Thomas et al. (https://doi.org/10.1084/jem.20200891) provide elegant technological and conceptual advances that further our understanding of the immune cells enriched at the maternal–fetal interface. Using new isolation strategies to better separate maternal- and fetal-derived cells, the authors identify previously undefined maternal-derived immune cells associated with the fetal-derived placenta and provide an in-depth analysis of the markers and characteristics of placental Hofbauer cells.

scholarly journals Characterization of Oral Squamous Cell Carcinoma Associated Inflammation: A Pilot Study

2021 ◽  
Vol 2 ◽  
Author(s):  
Catherine Laliberté ◽  
Nicole Ng ◽  
Denise Eymael ◽  
Kevin Higgins ◽  
Aiman Ali ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Immune Cells ◽  
Tumor Development ◽  
Tissue Analysis ◽  
Fluorescent Immunohistochemistry ◽  
Pro Inflammatory Cytokines

Background: Oral squamous cell carcinoma (OSCC) is a devastating disease that is usually associated with a dense associated inflammatory infiltrate. Characterizing tumor-associated inflammation is critical to understand the pathogenies of tumor development and progression.Methods: We have tested a protocol to analyze tissue and salivary immune cells and mediators of 37 patients with OSCC at different stages and compared to eight chronic periodontitis patients and 24 healthy controls. Tissue analysis was based on fluorescent immunohistochemistry (FIHC) and inflammatory mediators were analyzed using a Luminex-based 30-Plex panel. Immune cells were analyzed using multichannel flow cytometry including CD45, CD66b, CD3, CD4, CD8, CD25, CD56, CD68, CD138, PD-1, and PD-L1.Results: We show an increase in OSCC-associated inflammation characterized by increased pro-inflammatory cytokines including IL-6, IL-8, TNFα, and GMCSF and increased salivary immune cells.Conclusion: We described a new method to analyze salivary inflammatory markers that can be used in future studies to monitor disease progression and prognosis.

scholarly journals Immune cell-specific Cre reporter mouse labels a subset of CNS neurons

2019 ◽  
Author(s):  
Aurélie Bouteau ◽  
Botond Z. Igyártó
Keyword(s):  
Immune Cells ◽  
Langerhans Cells ◽  
Immune Cell ◽  
Neuronal Marker ◽  
Reporter Mouse ◽  
Cns Neurons ◽  
The Central Nervous System ◽  
Antigen Presenting

AbstractHuLangerin-Cre-YFPf/f mice were generated to specifically mark a subset of antigen presenting immune cells, called Langerhans cells (LCs). During histological characterization of these mice, we found that, in addition to LCs an uncharacterized cell population in the central nervous system (CNS) also expressed YFP. In this study, we found that the CNS YFP+ cells were negative for microglia and astrocyte markers, but they expressed mature neuronal marker NeuN and showed neuronal localization/morphology. Thus, these mice might be used to study the ontogeny, migration and the role of a subset of CNS neurons.

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