scholarly journals Sex‐specific impact of major depressive disorder on 12‐year change in glycemic status: results from a nationwide cohort study of adults without diabetes in Germany

2021 ◽  
Author(s):  
Julia Nübel ◽  
Julia Truthmann ◽  
Christin Heidemann ◽  
Yong Du ◽  
Rebecca Paprott ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Cohort Study ◽  
Depressive Disorder ◽  
Glycemic Status ◽  
Major Depressive ◽  
Specific Impact

scholarly journals Clinical laboratory tests and five-year incidence of major depressive disorder: a prospective cohort study of 433,890 participants from the UK Biobank

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Michael Wainberg ◽  
Stefan Kloiber ◽  
Breno Diniz ◽  
Roger S. McIntyre ◽  
Daniel Felsky ◽  
...  
Keyword(s):  
Public Health ◽  
Major Depressive Disorder ◽  
Cohort Study ◽  
Confidence Interval ◽  
Depressive Disorder ◽  
Blood Cell ◽  
Biological Processes ◽  
Uk Biobank ◽  
Major Depressive ◽  
The Uk

AbstractPrevention of major depressive disorder (MDD) is a public health priority. Identifying biomarkers of underlying biological processes that contribute to MDD onset may help address this public health need. This prospective cohort study encompassed 383,131 white British participants from the UK Biobank with no prior history of MDD, with replication in 50,759 participants of other ancestries. Leveraging linked inpatient and primary care records, we computed adjusted odds ratios for 5-year MDD incidence among individuals with values below or above the 95% confidence interval (<2.5th or >97.5th percentile) on each of 57 laboratory measures. Sensitivity analyses were performed across multiple percentile thresholds and in comparison to established reference ranges. We found that indicators of liver dysfunction were associated with increased 5-year MDD incidence (even after correction for alcohol use and body mass index): elevated alanine aminotransferase (AOR = 1.35, 95% confidence interval [1.16, 1.58]), aspartate aminotransferase (AOR = 1.39 [1.19, 1.62]), and gamma glutamyltransferase (AOR = 1.52 [1.31, 1.76]) as well as low albumin (AOR = 1.28 [1.09, 1.50]). Similar observations were made with respect to endocrine dysregulation, specifically low insulin-like growth factor 1 (AOR = 1.34 [1.16, 1.55]), low testosterone among males (AOR = 1.60 [1.27, 2.00]), and elevated glycated hemoglobin (HbA1C; AOR = 1.23 [1.05, 1.43]). Markers of renal impairment (i.e. elevated cystatin C, phosphate, and urea) and indicators of anemia and macrocytosis (i.e. red blood cell enlargement) were also associated with MDD incidence. While some immune markers, like elevated white blood cell and neutrophil count, were associated with MDD (AOR = 1.23 [1.07, 1.42]), others, like elevated C-reactive protein, were not (AOR = 1.04 [0.89, 1.22]). The 30 significant associations validated as a group in the multi-ancestry replication cohort (Wilcoxon p = 0.0005), with a median AOR of 1.235. Importantly, all 30 significant associations with extreme laboratory test results were directionally consistent with an increased MDD risk. In sum, markers of liver and kidney dysfunction, growth hormone and testosterone deficiency, innate immunity, anemia, macrocytosis, and insulin resistance were associated with MDD incidence in a large community-based cohort. Our results support a contributory role of diverse biological processes to MDD onset.

scholarly journals Neighborhood income and major depressive disorder in a large Dutch population: results from the LifeLines Cohort study

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Bart Klijs ◽  
Eva U. B. Kibele ◽  
Lea Ellwardt ◽  
Marij Zuidersma ◽  
Ronald P. Stolk ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Cohort Study ◽  
Depressive Disorder ◽  
Dutch Population ◽  
Major Depressive ◽  
Neighborhood Income

scholarly journals Major depressive disorder, suicidal thoughts and behaviours, and cannabis involvement in discordant twins: a retrospective cohort study

2017 ◽  
Vol 4 (9) ◽  
pp. 706-714 ◽  
Author(s):  
Arpana Agrawal ◽  
Elliot C Nelson ◽  
Kathleen K Bucholz ◽  
Rebecca Tillman ◽  
Richard A Grucza ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Cohort Study ◽  
Depressive Disorder ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Major Depressive ◽  
Suicidal Thoughts ◽  
Discordant Twins

scholarly journals The effect of anaesthetic dose on response and remission in electroconvulsive therapy for major depressive disorder: nationwide register-based cohort study

BJPsych Open ◽  
2021 ◽  
Vol 7 (2) ◽  
Author(s):  
Alexander Kronsell ◽  
Axel Nordenskjöld ◽  
Max Bell ◽  
Ridwanul Amin ◽  
Ellenor Mittendorfer-Rutz ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Cohort Study ◽  
Depressive Disorder ◽  
Electroconvulsive Therapy ◽  
Treatment Effect ◽  
Odds Ratio ◽  
High Dose ◽  
Major Depressive ◽  
Remission Rates ◽  
Deep Anaesthesia

Background Electroconvulsive therapy (ECT) is a safe and effective treatment for major depressive disorder (MDD). ECT treatment effect relies on induced generalised seizures. Most anaesthetics raise the seizure threshold and shorten seizure duration. There are no conclusive studies on the effect of anaesthetic dose on response and remission rates with ECT for MDD. Aims We aimed to examine the effect of different dose intervals of anaesthetics on response and remission after ECT for MDD. Method We conducted a nationwide cohort study, using data from Swedish registers. Low-, medium- and high-dose intervals, adjusted for age and gender, were constructed for each anaesthetic drug. Response and remission were measured with the Clinical Global Impression – Severity and Improvement scales (CGI-I and CGI-S), and a self-rated version of the Montgomery–Åsberg Depression Rating Scale (MADRS-S). Logistic regression models were used to calculate adjusted odds ratios for response and remission rates. Results The study included 7917 patients who received ECT for MDD during 2012–2018. Patients were given either thiopental (64.1%) or propofol (35.9%). Low-dose intervals of anaesthetics were associated with increased rates of response (CGI-I: odds ratio 1.22, 95% CI 1.07–1.40, P = 0.004; MADRS-S: odds ratio 1.31, 95% CI 1.09–1.56, P = 0.004) and remission (CGI-S: odds ratio 1.37, 95% CI 1.17–1.60, P ≤ 0.001; MADRS-S: odds ratio 1.31, 95% CI 1.10–1.54, P = 0.002). Conclusions We found improved treatment outcomes with low- compared with high-dose anaesthetic during ECT for MDD. To enhance treatment effect, deep anaesthesia during ECT for MDD should be avoided.

Major depressive disorder increased risk of psoriasis: A propensity score matched cohort study

2021 ◽  
Vol 278 ◽  
pp. 407-412 ◽  
Author(s):  
Yi-Hsien Chen ◽  
Wei-Ming Wang ◽  
I-Hsun Li ◽  
Hui-Han Kao ◽  
Chin-Bin Yeh ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Cohort Study ◽  
Propensity Score ◽  
Depressive Disorder ◽  
Matched Cohort ◽  
Major Depressive ◽  
Matched Cohort Study ◽  
Increased Risk

scholarly journals Remote assessment of disease and relapse in major depressive disorder (RADAR-MDD): a multi-centre prospective cohort study protocol

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
F. Matcham ◽  
◽  
C. Barattieri di San Pietro ◽  
V. Bulgari ◽  
G. de Girolamo ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Cohort Study ◽  
Depressive Disorder ◽  
Prospective Cohort Study ◽  
Study Protocol ◽  
Prospective Cohort ◽  
Major Depressive ◽  
Remote Assessment
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