scholarly journals Effect of human skin explants on the neurite growth of the PC12 cell line

2013 ◽  
Vol 22 (3) ◽  
pp. 224-225 ◽  
Author(s):  
Nicolas Lebonvallet ◽  
Jean-Pierre Pennec ◽  
Christelle Le Gall ◽  
Ulysse Pereira ◽  
Nicholas Boulais ◽  
...  
Keyword(s):  
Cell Line ◽  
Human Skin ◽  
Pc12 Cell ◽  
Neurite Growth ◽  
Pc12 Cell Line ◽  
Skin Explants

scholarly journals Establishment and Characterization of Methylmercury-Resistant PC12 Cell Line

1994 ◽  
Vol 102 ◽  
pp. 313 ◽  
Author(s):  
Kyoko Miura ◽  
Thomas W. Clarkson ◽  
Kazumasa Ikeda ◽  
Akira Naganuma ◽  
Nobumasa Imura
Keyword(s):  
Cell Line ◽  
Pc12 Cell ◽  
Pc12 Cell Line

scholarly journals Synaptotagmin VII Is Targeted to Dense-core Vesicles and Regulates Their Ca2+-dependent Exocytosis in PC12 Cells

2004 ◽  
Vol 279 (50) ◽  
pp. 52677-52684 ◽  
Author(s):  
Mitsunori Fukuda ◽  
Eiko Kanno ◽  
Megumi Satoh ◽  
Chika Saegusa ◽  
Akitsugu Yamamoto
Keyword(s):  
Plasma Membrane ◽  
Neuropeptide Y ◽  
Cell Line ◽  
Pc12 Cells ◽  
Pc12 Cell ◽  
Small Interfering Rna ◽  
Dense Core ◽  
Dense Core Vesicles ◽  
Pc12 Cell Line ◽  
Interfering Rna

It has recently been proposed that synaptotagmin (Syt) VII functions as a plasma membrane Ca2+sensor for dense-core vesicle exocytosis in PC12 cells based on the results of transient overexpression studies using green fluorescent protein (GFP)-tagged Syt VII; however, the precise subcellular localization of Syt VII is still a matter of controversy (plasma membraneversussecretory granules). In this study we established a PC12 cell line “stably expressing” the Syt VII-GFP molecule and demonstrated by immunocytochemical and immunoelectron microscopic analyses that the Syt VII-GFP protein is localized on dense-core vesicles as well as in other intracellular membranous structures, such as thetrans-Golgi network and lysosomes. Syt VII-GFP forms a complex with endogenous Syts I and IX, but not with Syt IV, and it colocalize well with Syts I and IX in the cellular processes (where dense-core vesicles are accumulated) in the PC12 cell line. We further demonstrated by an N-terminal antibody-uptake experiment that Syt VII-GFP-containing dense-core vesicles undergo Ca2+-dependent exocytosis, the same as endogenous Syt IX-containing vesicles. Moreover, silencing of Syt VII-GFP with specific small interfering RNA dramatically reduced high KCl-dependent neuropeptide Y secretion from the stable PC12 cell line (∼60% of the control cells), whereas the same small interfering RNA had little effect on neuropeptide Y secretion from the wild-type PC12 cells (∼85–90% of the control cells), indicating that the level of endogenous expression of Syt VII molecules must be low. Our results indicate that the targeting of Syt VII-GFP molecules to specific membrane compartment(s) is affected by the transfection method (transient expressionversusstable expression) and suggested that Syt VII molecule on dense-core vesicles functions as a vesicular Ca2+sensor for exocytosis in endocrine cells.

scholarly journals Establishment and characterization of methylmercury-resistant PC12 cell line.

1994 ◽  
Vol 102 (suppl 3) ◽  
pp. 313-315 ◽  
Author(s):  
K Miura ◽  
T W Clarkson ◽  
K Ikeda ◽  
A Naganuma ◽  
N Imura
Keyword(s):  
Cell Line ◽  
Pc12 Cell ◽  
Pc12 Cell Line

N-acyl dopamines induce cell death in PC12 cell line via induction of nitric oxide generation and oxidative stress

2016 ◽  
Vol 467 (1) ◽  
pp. 81-84 ◽  
Author(s):  
A. M. Ashba ◽  
M. G. Akimov ◽  
N. M. Gretskaya ◽  
V. V. Bezuglov
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Cell Death ◽  
Cell Line ◽  
Pc12 Cell ◽  
Pc12 Cell Line ◽  
Induce Cell Death ◽  
And Oxidative Stress

scholarly journals A role for cGMP during tetanus toxin blockade of acetylcholine release in the rat pheochromocytoma (PC12) cell line

1989 ◽  
Vol 9 (11) ◽  
pp. 3946-3954 ◽  
Author(s):  
K Sandberg ◽  
CJ Berry ◽  
E Eugster ◽  
TB Rogers
Keyword(s):  
Cell Line ◽  
Pc12 Cell ◽  
Tetanus Toxin ◽  
Acetylcholine Release ◽  
Pc12 Cell Line ◽  
Pheochromocytoma Pc12

Regulatory networks upon neurogenesis induction in PC12 cell line by small molecules

2019 ◽  
Vol 234 (10) ◽  
pp. 18813-18824
Author(s):  
Nafiseh Falsafi ◽  
Tahereh Soleimani ◽  
Hossein Fallahi ◽  
Mehri Azadbakht
Keyword(s):  
Small Molecules ◽  
Cell Line ◽  
Pc12 Cell ◽  
Regulatory Networks ◽  
Pc12 Cell Line

scholarly journals Retraction Note: Suppressor capacity of copper nanoparticles biosynthesized using Crocus sativus L. leaf aqueous extract on methadone-induced cell death in adrenal phaeochromocytoma (PC12) cell line

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Peng Zhang ◽  
Jian Cui ◽  
Shirin Mansooridara ◽  
Atoosa Shahriyari Kalantari ◽  
Akram Zangeneh ◽  
...  
Keyword(s):  
Cell Death ◽  
Cell Line ◽  
Aqueous Extract ◽  
Copper Nanoparticles ◽  
Pc12 Cell ◽  
Crocus Sativus ◽  
Pc12 Cell Line ◽  
Leaf Aqueous Extract ◽  
Retraction Notice ◽  
Crocus Sativus L

This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1038/s41598-020-77741-4.

Clostridium perfringens type a enterotoxin induces release of noradrenaline from the neurosecretory PC12 cell line

1987 ◽  
Vol 144 (1) ◽  
pp. 217-223 ◽  
Author(s):  
Kunihiro Ozutsumi ◽  
Nakaba Sugimoto ◽  
Morihiro Matsuda
Keyword(s):  
Cell Line ◽  
Clostridium Perfringens ◽  
Pc12 Cell ◽  
Type A ◽  
Release Of Noradrenaline ◽  
Pc12 Cell Line
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