N-acyl dopamines induce cell death in PC12 cell line via induction of nitric oxide generation and oxidative stress

2016 ◽  
Vol 467 (1) ◽  
pp. 81-84 ◽  
Author(s):  
A. M. Ashba ◽  
M. G. Akimov ◽  
N. M. Gretskaya ◽  
V. V. Bezuglov
2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Peng Zhang ◽  
Jian Cui ◽  
Shirin Mansooridara ◽  
Atoosa Shahriyari Kalantari ◽  
Akram Zangeneh ◽  
...  

This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1038/s41598-020-77741-4.


2005 ◽  
Vol 25 (2) ◽  
pp. 154-162 ◽  
Author(s):  
Joëlle A Hillion ◽  
Kenzo Takahashi ◽  
Dragan Maric ◽  
Christl Ruetzler ◽  
Jeffery L Barker ◽  
...  

Although ischemic tolerance has been described in a variety of primary cell culture systems, no similar in vitro models have been reported with any cell line. A model of ischemic preconditioning in the rat pheochromocytoma PC12 cell line is described here. When compared to nonpreconditioned cells, preexposure of PC12 cells to 6 hours of oxygen and glucose deprivation (OGD) significantly increased cell viability after 15 hours of OGD 24 hours later. Flow cytometry analysis of cells labeled with specific markers for apoptosis, Annexin V, and Hoechst 33342, and of DNA content, revealed that apoptosis is involved in OGD-induced PC12 cell death and that preconditioning of the cells mainly counteracts the effect of apoptosis. Immunocytochemistry of caspase-3, a central executioner in the apoptotic process, further confirmed the activation of apoptotic pathways in OGD-induced PC12 cell death. This model may be useful to investigate the cellular mechanisms involved in neuronal transient tolerance following ischemia.


2011 ◽  
Vol 44 (13) ◽  
pp. S179
Author(s):  
Arezou Rabzia ◽  
Mehri Azadbakht ◽  
Ali Bidmeshki Pour ◽  
Hasan Akrami

Biologia ◽  
2021 ◽  
Author(s):  
Cenk Kig ◽  
Elif Mertoglu ◽  
Alper Caliskan ◽  
Hizlan Hincal Agus ◽  
Evren Onay Ucar ◽  
...  

2019 ◽  
Vol 3 (24) ◽  
pp. 4155-4160 ◽  
Author(s):  
Silvia Masciarelli ◽  
Ernestina Capuano ◽  
Tiziana Ottone ◽  
Mariadomenica Divona ◽  
Serena Lavorgna ◽  
...  

Key Points RA synergizes with the N-glycosylation inhibitor tunicamycin and ATO to induce AML cell death via generation of ER and oxidative stress.


2010 ◽  
Vol 196 ◽  
pp. S216
Author(s):  
S. Abarikwu ◽  
M. Kashyap ◽  
I. Adedara ◽  
A. Pant ◽  
E. Farombi

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