scholarly journals Modeling CSF‐1 receptor deficiency diseases – how close are we?

FEBS Journal ◽  
2021 ◽  
Author(s):  
Violeta Chitu ◽  
Şölen Gökhan ◽  
E. Richard Stanley
Keyword(s):  
Author(s):  
Dale E. Bockman ◽  
L. Y. Frank Wu ◽  
Alexander R. Lawton ◽  
Max D. Cooper

B-lymphocytes normally synthesize small amounts of immunoglobulin, some of which is incorporated into the cell membrane where it serves as receptor of antigen. These cells, on contact with specific antigen, proliferate and differentiate to plasma cells which synthesize and secrete large quantities of immunoglobulin. The two stages of differentiation of this cell line (generation of B-lymphocytes and antigen-driven maturation to plasma cells) are clearly separable during ontogeny and in some immune deficiency diseases. The present report describes morphologic aberrations of B-lymphocytes in two diseases in which second stage differentiation is defective.


1917 ◽  
Vol 31 (1) ◽  
pp. 229-253 ◽  
Author(s):  
E.V. McCollum ◽  
W. Pitz
Keyword(s):  

1981 ◽  
Vol 2 (9) ◽  
pp. 72-73
Author(s):  
Bruce S. Rabin ◽  
Kathryn Kraus
Keyword(s):  

1967 ◽  
Vol 21 (1) ◽  
pp. 127-136 ◽  
Author(s):  
J. Bunyan ◽  
J. Green ◽  
A. T. Diplock ◽  
D. Robinson

1. The activities of several lysosomal hydrolases were measured in the tissues of chicks suffering from nutritional muscular dystrophy, encephalomalacia or exudative diathesis.2. In dystrophic breast muscle, β-glucuronidase was raised five- to six-fold, cathepsin fourfold and acid phosphatase 1.5-fold. No change was found in the subcellular distribution of β-glucuronidase.3. Chicks with encephalomalacia showed no changes in the β-glucuronidase, β-galactosidase, acid phosphatase or β-acetylglucosaminase activities of cerebellum or brain. Subcellular distribution of β-glucuronidase and β-galactosidase in these tissues was also unchanged.4. In exudative diathesis, hydrolases were found in the exudate, and there was increased activity in the subcutaneous tissue first showing haemorrhages. Increased hydrolytic activity was found in liver, spleen and kidney. Breast muscle was not always affected by the exudative condition, but, when it too degenerated, its hydrolase activity increased.5. β-Glucuronidase activity was measured in the serums of chicks suffering from each of the three deficiency diseases. None of the diseases caused a rise in activity.


Cephalalgia ◽  
2000 ◽  
Vol 20 (3) ◽  
pp. 164-169 ◽  
Author(s):  
B de Lignières ◽  
E A MacGregor

Menopause, the permanent cessation of menstruation, is due to ovarian failure, which may lead to oestrogen deficiency diseases, particularly osteoporosis, cardiovascular disease and cerebrovascular disease. Mortality and morbidity caused by these conditions can be modified by using hormone replacement therapy, but the benefits of this therapy must be weighed against the increased risk of breast cancer and the symptomatic side-effects the treatment may cause. The combination of transdermal oestrogen and natural progesterone offers the most favourable risk-to-benefit profile.


1934 ◽  
Vol 59 (1) ◽  
pp. 21-34 ◽  
Author(s):  
H. M. Zimmerman ◽  
Ethel Burack

Adult dogs maintained on an artificial, balanced ration adequate in all dietary essentials as far as is known except water-soluble, heat-stable vitamin B2 (G) developed, after a sufficient time, a slowly progressive disease characterized by loss of weight, persistent vomiting and diarrhea, and marked muscular weakness, which ended fatally in from 200 to over 300 days. The clinical features of this condition, as pointed out in the discussion, are quite different from those characterizing the canine disease known as black tongue. The anatomic changes in this condition consist of marked demyelination of the peripheral nerves, including the vagus; degeneration of the medullary sheaths and replacement by gliosis of the posterior columns of the spinal cord, particularly the fasciculi graciles; degeneration of the medullary sheaths of the posterior and less often of the anterior nerve roots of the cord; occasionally slight degenerative changes in most of the other fiber tracts of the cord. Attention is called to the fact that degenerative lesions in the central nervous system similar or identical with these have frequently been described in pellagra in man.


PEDIATRICS ◽  
1963 ◽  
Vol 31 (2) ◽  
pp. 329-338
Author(s):  

MANAGEMENT of the allergic infant often includes extensive dietary restriction in addition to avoidance of milk. A milkfree formula may thus become a major or even sole source of most essential nutrients for many months. Furthermore, the occasional coexistence of anorexia and intercurrent infection in children with allergic manifestations, and losses of proteinthrough the skin of patients with severe eczema, makes adequacy of diet a major concern of the physician caring for such patients. Published reports of deficiency diseases developing in infants receiving various milk-free formulas indicate the importance of an awareness of composition and nutritional properties of these diets. Deficiencies of vitamin A and thiamine, have occurred in infants receiving milk-free formulas not fortified with vitamins, and goiter due to iodine deficiency (or increased iodine requirement) has been reported to occur in infants receiving a soya bean formula unsupplemented with iodine. The present report provides information regarding composition and nutritional adequacy of certain infant formulas commonly employed as cow milk substitutes. SOYA BEAN PRODUCTS Composition Information on the composition of the most frequently used commercial preparations is given in Table I. Soyalac: Liquid and powder products are prepared from an aqueous extrat of whole soya beans to which has been added soya oil, sucrose, dextrose, dextrins, maltose, and iodised sodium chloride, When diluted with water to supply 67 cal/100 ml (20 cal/oz). Soyalac liquid supplies 2.05 gm of protein/100 ml, the least protein content of commercially available soya bean formulas. Formulas of Soyalac Powder with the same caloric strength provide 2.85 gm of protein/100 ml and differ in other important respects from Soyalac liquid (Table I).


PEDIATRICS ◽  
1948 ◽  
Vol 1 (6) ◽  
pp. 846-846
Author(s):  
R. A. GOOD

In the fifth edition of "Diagnostik der Kinderkrankheiten" Dr. Feer has once again attempted to present the elements of pediatric diagnosis in the form of a timely practical handbook for medical students and busy practitioners. Following the semeiotic arrangement employed in previous editions the author draws on his extensive pediatric experience to provide a wealth of accurate diagnostic detail in a refreshingly familiar style. Although the spectrum of pediatric diagnosis is, in general, covered admirably, certain important aspects are neglected. Problems peculiar to the diagnosis of virus and parasitic infections in childhood receive little attention; only the bare elements in the diagnosis of deficiency diseases and endocrine disturbances are discussed; and the fields of acute and chronic poisoning, as well as the subject of malignancy in childhood, are incompletely elucidated.


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