scholarly journals The two faces of cyanide: an environmental toxin and a potential novel mammalian gasotransmitter

FEBS Journal ◽  
2021 ◽  
Author(s):  
Karim Zuhra ◽  
Csaba Szabo
Keyword(s):  
Environmental Toxin

scholarly journals Older African Americans’ Perspectives on Exposure to Structural Discrimination Across Contexts and the Life Course

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 689-689
Author(s):  
Sarah LaFave ◽  
Sarah Szanton ◽  
Roland Thorpe
Keyword(s):  
African Americans ◽  
Life Course ◽  
Healthcare Services ◽  
Community Dwelling ◽  
Structured Interviews ◽  
Older African Americans ◽  
Environmental Toxin ◽  
Development Of Instrument ◽  
The Life Course ◽  
Interpersonal Level

Abstract This presentation reports on findings from the first phase of a mixed methods study aimed at developing an instrument to assess older African Americans’ exposure to structural racial discrimination. We conducted semi-structured interviews with older African Americans about their perspectives on and exposure to structural discrimination. Participants (n=20) were community-dwelling African Americans aged fifty and older in Baltimore, MD. Participants described exposure to structural discrimination that had accumulated across the life course and across the contexts of education, employment, healthcare services, criminal justice system, neighborhood factors, media and marketing of unhealthy products, environmental toxin exposures, and income, credit and wealth. In the next phase of the study, we will incorporate these findings into the development of instrument items. Developing and testing a tool to assess exposure to discrimination beyond the interpersonal level is an important step in identifying solutions to mitigate the contribute of discrimination to racial health disparities.

Cadmium (environmental toxin series 2)

1989 ◽  
Vol 57 (1) ◽  
pp. 82-83
Author(s):  
F. Moriarty
Keyword(s):  
Environmental Toxin

scholarly journals Protective effects of Trifolium alexandrinum L. against lung injury induced by environmental toxin CCl4 in experimental rats

2016 ◽  
Vol 60 (1) ◽  
pp. 30433 ◽  
Author(s):  
Rahmat Ali Khan ◽  
Huda Mohammad Alkreathy ◽  
Abdus Saboorshah ◽  
Mushtaq Ahmed ◽  
Samiullah Khan
Keyword(s):  
Lung Injury ◽  
Trifolium Alexandrinum ◽  
Protective Effects ◽  
Environmental Toxin

scholarly journals Prognostic value of p53, c-ErbB2 and tunel data in upper urothelial carcinoma associated with Balkan nephropathy

2014 ◽  
Vol 66 (2) ◽  
pp. 641-649 ◽  
Author(s):  
Marina Savin ◽  
Z. Dzamic ◽  
M. Baralic ◽  
Sanja Radojevic-Skodric ◽  
Jelena Marinkovic ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Prognostic Value ◽  
Growth Factor Receptor ◽  
Nuclear Antigen ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Balkan Nephropathy ◽  
Apoptosis Detection ◽  
Environmental Toxin ◽  
Her 2 ◽  
Epidermal Growth

A characteristic tumor suppressor protein 53 (p53) mutational profile of genotoxic action of aristolochic acid was identified in the upper urothelial carcinoma (UUTT) associated with Balkan nephropathy (BEN). In the present study, we examined the prognostic value of tissue-based molecular markers in overall-survival (OS) risk after surgical treatment of UUTT, adjusted for gender, age and urological characteristics in 32 patients with BEN. Immunohistochemical examination of p53, the proliferation cell nuclear antigen (PCNA), the human epidermal growth factor receptor 2 (c-ErbB2; also known as HER-2/neu) proto-oncogene and the in situ terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay for apoptosis detection were used to examine serial tumor sections. The median OS-time was 60 months for UUTT operation; the mortality rate (18.7%) was related to (new) disease (re)occurrence or invasion in 12-216 months. High-grade (p=0.029), TUNEL>0.36%+ cells (p=0.010), and c-ErbB2+ cells (p=0.014) can define the risk of tumor invasion. Patients with Balkan nephropathy that develop UUTT at a stage greater than pT1 (with apoptosis TUNEL+ cells >0.36% and p53+ cells greater than 10%) were at high risk of poor-OS after the tumor surgery (h(x)=6.35; p=0.045). The obtained data present evidence for p53, cErbB2 and apoptosis deregulation, as a result of environmental toxin action. This is the first report of molecular biomarker linkage with OS for BEN-associated UUTT.

scholarly journals On Membrane Motor Activity and Chloride Flux in the Outer Hair Cell: Lessons Learned from the Environmental Toxin Tributyltin

2005 ◽  
Vol 88 (3) ◽  
pp. 2350-2362 ◽  
Author(s):  
Lei Song ◽  
Achim Seeger ◽  
Joseph Santos-Sacchi
Keyword(s):  
Motor Activity ◽  
Hair Cell ◽  
Outer Hair Cell ◽  
Lessons Learned ◽  
Chloride Flux ◽  
Environmental Toxin

Acrolein, a commonly found environmental toxin, causes oocyte mitochondrial dysfunction and negatively affects embryo development

2018 ◽  
Vol 52 (9) ◽  
pp. 929-938 ◽  
Author(s):  
Roohi Jeelani ◽  
Charalampos Chatzicharalampous ◽  
Hamid-Reza Kohan-Ghadr ◽  
Awoniyi Awonuga ◽  
Narendra Joshi ◽  
...  
Keyword(s):  
Mitochondrial Dysfunction ◽  
Embryo Development ◽  
Environmental Toxin

Advanced sensing platform for electrochemical monitoring of the environmental toxin; bisphenol A

2020 ◽  
Vol 190 ◽  
pp. 110088 ◽  
Author(s):  
Hoda Ezoji ◽  
Mostafa Rahimnejad ◽  
Ghasem Najafpour-Darzi
Keyword(s):  
Bisphenol A ◽  
Sensing Platform ◽  
Environmental Toxin ◽  
Electrochemical Monitoring

scholarly journals Exposure to the Harmful Algal Bloom (HAB) Toxin Microcystin-LR (MC-LR) Prolongs and Increases Severity of Dextran Sulfate Sodium (DSS)-Induced Colitis

Toxins ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 371 ◽  
Author(s):  
Robin C. Su ◽  
Thomas M. Blomquist ◽  
Andrew L. Kleinhenz ◽  
Fatimah K. Khalaf ◽  
Prabhatchandra Dube ◽  
...  
Keyword(s):  
Weight Loss ◽  
Algal Blooms ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Harmful Algal Bloom ◽  
Tnf Α ◽  
Environmental Toxin ◽  
Genetic And Environmental Factors ◽  
The Impact ◽  
Bloody Stools

Inflammatory Bowel Disease (IBD) represents a collection of gastrointestinal disorders resulting from genetic and environmental factors. Microcystin-leucine arginine (MC-LR) is a toxin produced by cyanobacteria during algal blooms and demonstrates bioaccumulation in the intestinal tract following ingestion. Little is known about the impact of MC-LR ingestion in individuals with IBD. In this study, we sought to investigate MC-LR’s effects in a dextran sulfate sodium (DSS)-induced colitis model. Mice were separated into four groups: (a) water only (control), (b) DSS followed by water (DSS), (c) water followed by MC-LR (MC-LR), and (d) DSS followed by MC-LR (DSS + MC-LR). DSS resulted in weight loss, splenomegaly, and severe colitis marked by transmural acute inflammation, ulceration, shortened colon length, and bloody stools. DSS + MC-LR mice experienced prolonged weight loss and bloody stools, increased ulceration of colonic mucosa, and shorter colon length as compared with DSS mice. DSS + MC-LR also resulted in greater increases in pro-inflammatory transcripts within colonic tissue (TNF-α, IL-1β, CD40, MCP-1) and the pro-fibrotic marker, PAI-1, as compared to DSS-only ingestion. These findings demonstrate that MC-LR exposure not only prolongs, but also worsens the severity of pre-existing colitis, strengthening evidence of MC-LR as an under-recognized environmental toxin in vulnerable populations, such as those with IBD.

Sign in / Sign up

Export Citation Format

Share Document