Transferrin receptor 1 overexpression is associated with tumour de‐differentiation and acts as a potential prognostic indicator of hepatocellular carcinoma

2019 ◽  
Vol 75 (1) ◽  
pp. 63-73 ◽  
Author(s):  
Makiko Adachi ◽  
Keita Kai ◽  
Koutaro Yamaji ◽  
Takao Ide ◽  
Hirokazu Noshiro ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transferrin Receptor ◽  
Prognostic Indicator ◽  
Transferrin Receptor 1

scholarly journals miR-148a regulates expression of the transferrin receptor 1 in hepatocellular carcinoma

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Kamesh R. Babu ◽  
Martina U. Muckenthaler
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transferrin Receptor ◽  
Transferrin Receptor 1

Sustained oxidative stress (H2O2) increases hepatic iron accumulation via translational stimulation of transferrin receptor 1 synthesis independent of the IRE/IRP network

2008 ◽  
Vol 46 (01) ◽  
Author(s):  
B Andriopoulos ◽  
S Hegedüsch ◽  
J Mangin ◽  
J Wang ◽  
K Pantopoulos ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Transferrin Receptor ◽  
Iron Accumulation ◽  
Hepatic Iron ◽  
Transferrin Receptor 1 ◽  
Stimulation Of

scholarly journals Perioperative Geriatric Assessment as A Predictor of Long-Term Hepatectomy Outcomes in Elderly Patients with Hepatocellular Carcinoma

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 842
Author(s):  
Masaki Kaibori ◽  
Hideyuki Matsushima ◽  
Morihiko Ishizaki ◽  
Hisashi Kosaka ◽  
Kosuke Matsui ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Geriatric Assessment ◽  
Proportional Hazards ◽  
Prognostic Indicator ◽  
Cox Proportional Hazards ◽  
Rate Of Change ◽  
Score Change ◽  
Comorbidity Burden ◽  
Reduction Group

This retrospective study recorded pertinent baseline geriatric assessment variables to identify risk factors for recurrence-free survival (RFS) and overall survival (OS) after hepatectomy in 100 consecutive patients aged ≥70 years with hepatocellular carcinoma. Patients had geriatric assessments of cognition, nutritional and functional statuses, and comorbidity burden, both preoperatively and at six months postoperatively. The rate of change in each score between preoperative and postoperative assessments was calculated by subtracting the preoperative score from the score at six months postoperatively, then dividing by the score at six months postoperatively. Patients with score change ≥0 comprised the maintenance group, while patients with score change <0 comprised the reduction group. The change in Geriatric 8 (G8) score at six months postoperatively was the most significant predictive factor for RFS and OS among the tested geriatric assessments. Five-year RFS rates were 43.4% vs. 6.7% (maintenance vs. reduction group; HR, 0.19; 95%CI, 0.11–0.31; p < 0.001). Five-year OS rates were 73.8% vs. 17.8% (HR, 0.12; 95%CI, 0.06–0.25; p < 0.001). Multivariate Cox proportional hazards analysis showed that perioperative maintenance of G8 score was an independent prognostic indicator for both RFS and OS. Perioperative changes in G8 scores can help forecast postoperative long-term outcomes in these patients.

scholarly journals Roquin is a major mediator of iron-regulated changes to transferrin receptor-1 mRNA stability

iScience ◽  
2021 ◽  
Vol 24 (4) ◽  
pp. 102360
Author(s):  
Victor M. Corral ◽  
Eric R. Schultz ◽  
Richard S. Eisenstein ◽  
Gregory J. Connell
Keyword(s):  
Mrna Stability ◽  
Transferrin Receptor ◽  
Transferrin Receptor 1 ◽  
Major Mediator

scholarly journals Transferrin receptor 1-mediated iron uptake plays an essential role in hematopoiesis

Haematologica ◽  
2019 ◽  
Vol 105 (8) ◽  
pp. 2071-2082 ◽  
Author(s):  
Shufen Wang ◽  
Xuyan He ◽  
Qian Wu ◽  
Li Jiang ◽  
Liyun Chen ◽  
...  
Keyword(s):  
Transferrin Receptor ◽  
Iron Uptake ◽  
Essential Role ◽  
Transferrin Receptor 1

scholarly journals Proximal tubule transferrin uptake is modulated by cellular iron and mediated by apical membrane megalin–cubilin complex and transferrin receptor 1

2019 ◽  
Vol 294 (17) ◽  
pp. 7025-7036 ◽  
Author(s):  
Craig P. Smith ◽  
Wing-Kee Lee ◽  
Matthew Haley ◽  
Søren B. Poulsen ◽  
Frank Thévenod ◽  
...  
Keyword(s):  
Proximal Tubule ◽  
Transferrin Receptor ◽  
Apical Membrane ◽  
Cellular Iron ◽  
Transferrin Receptor 1 ◽  
Transferrin Uptake

Expression of iron transport proteins divalent metal transporter-1, Ferroportin-1, HFE and transferrin receptor-1 in human monocyte-derived dendritic cells

2007 ◽  
Vol 25 (3) ◽  
pp. 287-296 ◽  
Author(s):  
Martin Brinkmann ◽  
Regina Teuffel ◽  
Nihay Laham ◽  
Rachel Ehrlich ◽  
Patrice Decker ◽  
...  
Keyword(s):  
Transferrin Receptor ◽  
Iron Transport ◽  
Human Monocyte ◽  
Transport Proteins ◽  
Divalent Metal ◽  
Divalent Metal Transporter 1 ◽  
Divalent Metal Transporter ◽  
Metal Transporter ◽  
Ferroportin 1 ◽  
Transferrin Receptor 1

Plasma Level of Interleukin-35 as an Independent Prognostic Indicator in Hepatocellular Carcinoma

2016 ◽  
Vol 61 (12) ◽  
pp. 3513-3521 ◽  
Author(s):  
Xiangting Qiu ◽  
Xinhua Wang ◽  
Yucui Song ◽  
Lingling Chen
Keyword(s):  
Hepatocellular Carcinoma ◽  
Plasma Level ◽  
Prognostic Indicator

Expression of transferrin receptor 1, proliferating cell nuclear antigen, p27Kip1 and calbindin in the fetal and neonatal feline cerebellar cortex

2013 ◽  
Vol 196 (3) ◽  
pp. 388-393 ◽  
Author(s):  
Luc Poncelet ◽  
Marie Springinsfeld ◽  
Kunie Ando ◽  
Céline Héraud ◽  
Anna Kabova ◽  
...  
Keyword(s):  
Cerebellar Cortex ◽  
Transferrin Receptor ◽  
Proliferating Cell Nuclear Antigen ◽  
Nuclear Antigen ◽  
Transferrin Receptor 1 ◽  
Proliferating Cell

scholarly journals NDRG3 overexpression is associated with a poor prognosis in patients with hepatocellular carcinoma

2018 ◽  
Vol 38 (6) ◽  
Author(s):  
Ji-sheng Jing ◽  
Hongbo Li ◽  
Shun-cai Wang ◽  
Jiu-ming Ma ◽  
La-qing Yu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cox Regression ◽  
Survival Curve ◽  
Disease Free Survival ◽  
Prognostic Indicator ◽  
Clinicopathological Characteristics ◽  
Pcr Analysis ◽  
Kaplan Meier ◽  
Tumor Tissues ◽  
The Relationship

N-myc downstream-regulated gene 3 (NDRG3), an important member of the NDRG family, is involved in cell proliferation, differentiation, and other biological processes. The present study analyzed NDRG3 expression in hepatocellular carcinoma (HCC) and explored the relationship between expression of NDRG3 in HCC patients and their clinicopathological characteristics. We performed quantitative real-time reverse-transcription polymerase chain reaction (qRT-PCR) analysis and immunohistochemistry (IHC) analyses on HCC tissues to elucidate NDRG3 expression characteristics in HCC patients. Kaplan–Meier survival curve and Cox regression analyses were used to evaluate the prognoses of 102 patients with HCC. The results revealed that compared with non-tumor tissues, HCC tissues showed significantly higher NDRG3 expression. In addition, our analyses showed that NDRG3 expression was statistically associated with tumor size (P=0.048) and pathological grade (P=0.001). Survival analysis and Kaplan–Meier curves revealed that NDRG3 expression is an independent prognostic indicator for disease-free survival (P=0.002) and overall survival (P=0.005) in HCC patients. The data indicate that NDRG3 expression may be considered as a oncogenic biomarker and a novel predictor for HCC prognosis.

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