scholarly journals Peripheral blood levels of CXCL10 are a useful marker for diabetic polyneuropathy in subjects with type 2 diabetes

2021 ◽  
Author(s):  
Pilar Ascaso ◽  
Ana Palanca ◽  
Sergio Martinez‐Hervás ◽  
María Jesús Sanz ◽  
Juan F. Ascaso ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Peripheral Blood ◽  
Diabetic Polyneuropathy ◽  
Blood Levels

scholarly journals Elevated peripheral blood levels of CXCL10 are associated with the presence of diabetic polyneuropathy in subjects with type 2 diabetes

2020 ◽  
Author(s):  
Pilar Ascaso ◽  
Ana Palanca ◽  
Sergio Martinez-Hervas ◽  
María Jesús Sanz ◽  
Juan F Ascaso ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Peripheral Blood ◽  
Diabetic Polyneuropathy ◽  
Blood Levels

Abstract The authors have withdrawn this preprint due to author disagreement.

Alterations in peripheral blood levels of TIMP-1, MMP-2, and MMP-9 in patients with type-2 diabetes

2005 ◽  
Vol 69 (2) ◽  
pp. 175-179 ◽  
Author(s):  
Seung Won Lee ◽  
Kyoung Eun Song ◽  
Dong Sun Shin ◽  
Sung Min Ahn ◽  
Eun Suk Ha ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Peripheral Blood ◽  
Blood Levels

scholarly journals Elevated peripheral blood levels of CXCL10 are associated with the presence of diabetic polyneuropathy in subjects with type 2 diabetes

2020 ◽  
Author(s):  
Pilar Ascaso ◽  
Ana Palanca ◽  
Sergio Martinez-Hervas ◽  
María Jesús Sanz ◽  
Juan F Ascaso ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Plasma Levels ◽  
Nerve Repair ◽  
Diabetic Polyneuropathy ◽  
Serum Levels ◽  
Therapeutic Strategies ◽  
Blood Levels ◽  
High Morbidity ◽  
Circulating Levels

Abstract Background : Diabetic peripheral neuropathy (DPN) has high morbidity and mortality. Major risk factors of DPN include metabolic changes, duration of diabetes, nerve ischemia, and derangements in regeneration and nerve repair programs. The implication of chemokines in the pathogenesis of various neuropathies and neuropathic pain processes has been studied previously. This pilot study aimed to evaluate the association between plasma levels of chemokines CXCL9, CXCL10, and CXCL11 with the presence of DPN in a cohort of type 2 diabetes (T2D) patients. Methods : We have studied a total of 73 T2D patients (36 patients with DPN, and 37 without DPN). DPN was established through the Semmes-Weinstein test (SW). Plasma levels of circulating chemokines CXCL9, CXCL10, and CXCL11 were determined using Duoset ELISA kits (Abingdon, UK). Results: In T2D patients with similar gender distribution, duration of the disease, peripheral macroangiopathy, and metabolic control, we detected significantly higher serum levels of chemokine CXCL10 among patients with DPN than among patients without DPN (57.6 ± 38.3 vs. 38.1 ± 33.4 pg/mL, respectively; p = 0.034). Serum levels of chemokine CXCL9 were also higher among patients with DPN (188.1 ± 72.7 and 150.4 ± 83.6 pg/mL, respectively, p = 0.06). Conclusions : DPN in T2D patients was associated with a significant increase in CXCL10 circulating levels, suggesting a role for this chemokine in the DPN. Novel inflammatory markers that allow for early detection and therapeutic strategies in order to reverse and prevent the DPN should be investigated.

scholarly journals Isometric knee extension force in Japanese type 2 diabetic patients without apparent diabetic polyneuropathy: Data from the Multicenter Survey of the Isometric Lower Extremity Strength in Type 2 Diabetes study

2019 ◽  
Vol 7 ◽  
pp. 205031211882341 ◽  
Author(s):  
Takuo Nomura ◽  
Tomoyasu Ishiguro ◽  
Masayoshi Ohira ◽  
Hiroyuki Oka ◽  
Yukio Ikeda
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Polyneuropathy ◽  
Knee Extension ◽  
Diabetic Patients ◽  
Control Subjects ◽  
Multicenter Survey ◽  
Isometric Knee Extension ◽  
Extension Force ◽  
Healthy Control

Objectives: To determine standard reference values for isometric knee extension force using a cohort of Japanese type 2 diabetic patients without diabetic polyneuropathy. Methods: Patient data were collected from the Multicenter Survey of the Isometric Lower Extremity Strength in Type 2 Diabetes study and compared with previously published data of healthy control subjects. In total, we enrolled 898 patients with type 2 diabetes aged 30–87 years, who did not have diabetic polyneuropathy. The control group included 510 healthy subjects aged 30–88 years. Maximum isometric knee extension force (KEF) values were obtained by using a hand-held dynamometer with belt stabilization. In addition, KEF (kgf) was adjusted for bodyweight (kg) to calculate %KEF. Results: KEF and %KEF decreased with age in both patients with diabetes and healthy control subjects. The mean values of KEF and %KEF in patients with diabetes were reduced by 9.7% and 20.8%, respectively, in males, and by 11.6% and 23.0%, respectively, in females compared to the values in healthy control subjects. Conclusion: KEF and %KEF in patients with type 2 diabetes without diabetic polyneuropathy may reduce by approximately 10% and 20%, respectively, compared to these values in healthy control subjects. This study provides reference values for isometric KEF with respect to sex in a population covering a wide age range.

scholarly journals Distinguishable Immunologic Characteristics of COVID-19 Patients with Comorbid Type 2 Diabetes Compared with Nondiabetic Individuals

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Ruxing Zhao ◽  
Yujing Sun ◽  
Yongyuan Zhang ◽  
Weili Wang ◽  
Shouyu Wang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Immunological Response ◽  
Clinical Severity ◽  
Blood Levels ◽  
Immunological Parameters ◽  
Global Pandemic ◽  
Tnf Α ◽  
Significant Difference ◽  
Ifn Γ

Background. COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has threatened every civilian as a global pandemic. The immune system poses the critical interactive chain between the human body and the virus. Here, we make efforts to examine whether comorbidity with type 2 diabetes (T2D) affects the immunological response in COVID-19 patients. Methods. We conducted a retrospective pilot study investigating immunological characteristics of confirmed cases of COVID-19 with or without comorbid T2D. Two subcohorts of sex- and age-matched participants were eligible for data analysis, of which 33 participants were with T2D and the remaining 37 were nondiabetic (NDM). Cellular immunity was assessed by flow cytometric determination of surface markers including CD3, CD4, CD8, CD19, CD16, and CD56 in peripheral blood. Levels of C reactive protein, immunoglobulin (IgG, IgM, IgA, and IgE), and complements (C3, C4) were detected by rate nephelometry immunoassay. And Th1/Th2 cytokines (IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ) were detected by Cytometric Bead Array. Results. Neutrophil counts were found to be significantly higher in the T2D group than in the NDM group and had a significant relevance with clinical severity. Lymphocyte frequencies showed no significant differences in the two groups. However, the proportions and absolute counts of T, Tc, Th, and NK cells decreased in both groups to different degrees. An abnormal increase in neutrophil count and a decrease in lymphocyte subpopulations may represent risk factors of COVID-19 severity. The level of IgG, IgM, IgA, C3, and C4 showed no significant difference between the two groups, while the IgE levels were higher in the T2D group than in the NDM group ( p < 0.05 ). Th1 cytokines including IFN-γ, TNF-α, and IL-6, as well as CRP, appeared significantly higher in the T2D group. Conclusions. The COVID-19 patients comorbid with T2D demonstrated distinguishable immunological parameters, which represented clinical relevancies with the predisposed disease severity in T2D.

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