CHAPTER VI: CLINICAL SYMPTOMS RELATED TO CALCIUM AND PHOSPHATE METABOLISM IN CHRONIC RENAL FAILURE, WITH PARTICULAR REFERENCE TO THE EFFECT OF lα-HYDROXYVITAMIN D3

2009 ◽  
Vol 207 (S638) ◽  
pp. 65-68
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Clinical Symptoms ◽  
Phosphate Metabolism ◽  
Calcium And Phosphate Metabolism

scholarly journals Acetazolamide Intoxication in an Elderly Patient with Diabetes and Chronic Renal Failure after Cataract Surgery

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Juliana Maria Kerber ◽  
Juliana Dias de Mello ◽  
Karolinny Borinelli de Aquino Moura ◽  
Gustavo Cardoso da Silva ◽  
Iuri Christmann Wawrzeniak ◽  
...  
Keyword(s):  
Elderly Patient ◽  
Renal Failure ◽  
Metabolic Acidosis ◽  
Chronic Renal Failure ◽  
Clinical Symptoms ◽  
Open Angle Glaucoma ◽  
Rare Complication ◽  
Severe Metabolic Acidosis ◽  
Ophthalmic Surgery ◽  
Drug Concentrations

Carbonic anhydrase inhibitors, such as acetazolamide, are widely used in the treatment of open-angle glaucoma. Severe metabolic acidosis is a rare complication of acetazolamide use, and life-threatening acidosis occurs most commonly in elderly patients, in patients with advanced renal failure, and in patients with diabetes. We describe an unusual case of an elderly patient with diabetic nephropathy and chronic renal failure who presented to the emergency department with severe metabolic acidosis and coma after exposure to high doses of acetazolamide in the postoperative period of ophthalmic surgery. As symptoms of acetazolamide intoxication and uremia are similar, high suspicion is required to detect excessive plasma drug concentrations and intoxication in patients presenting with concomitant uremia. Clinical symptoms are potentially reversible with prompt diagnosis and treatment, including supportive treatment, bicarbonate therapy, and renal replacement therapy. Hemodialysis is particularly helpful in the management of acetazolamide overdose as the medication is dialyzable.

scholarly journals Based on HIF-1α/Wnt/β-Catenin Pathway to Explore the Effect of Qingshen Granules on Chronic Renal Failure Patients: A Randomized Controlled Trial

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Yiping Wang ◽  
Lei Zhang ◽  
Hua Jin ◽  
Dong Wang
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Treatment Group ◽  
Signaling Pathway ◽  
Clinical Symptoms ◽  
Controlled Trial ◽  
Serum Levels ◽  
Control Group ◽  
And Control ◽  
E Cadherin

Objectives. This study investigates the effect of Qingshen Granules (QSG) on chronic renal failure patients and the HIF-1α/Wnt/β-catenin signaling pathway. Methods. Subjects were randomly divided into treatment and control groups, with 42 patients in each group. Participants in the treatment group received 10 g oral doses of QSG 3 times a day, for 12 weeks, whereas subjects in the control group were given a placebo. The effective rates of traditional Chinese medicine (TCM) symptom, serum creatinine (Scr), and estimate glomerular filtration rate (eGFR) as well as the serum levels of HIF-1α, Wnt1, β-catenin, α-SMA, and E-cadherin were evaluated. Results. Eighty patients completed the treatment program and two dropped out. After 12 weeks, the effective rates of TCM symptom and eGFR were found to be higher in the treatment group than in the control group, with statistically significant differences (P = 0.024 and 0.019, respectively). Meanwhile, lower levels of HIF-1α, Wnt1, β-catenin, α-SMA, and E-cadherin were detected in the treatment group, and the differences were statistically significant (P ≤ 0.001, P = 0.001, P ≤ 0.001, P ≤ 0.001, and P = 0.039). No adverse events occurred during the study. Conclusions. QSG can alleviate the clinical symptoms of chronic renal failure (CRF) and protect renal function in patients by influencing the HIF-1α/Wnt/β-catenin signaling pathway. The treatment exhibits no adverse effects and is thus safe to be used by humans.

scholarly journals Prevalence of Intestinal Protozoa among Saudi Patients with Chronic Renal Failure: A Case-Control Study

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Yousry A. Hawash ◽  
Laila Sh. Dorgham ◽  
El-Amir M. Amir ◽  
Osama F. Sharaf
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Case Control Study ◽  
Clinical Symptoms ◽  
Giardia Duodenalis ◽  
Case Control ◽  
Intestinal Protozoa ◽  
Stool Samples ◽  
Matched Case ◽  
Control Study

It has been hypothesized that chronic renal failure (CRF) predisposes patients to infection with intestinal protozoa. We tested this hypothesis with a matched case-control study to determine the prevalence of these protozoa and their diarrhea associated symptoms among 50 patients with CRF (cases) from Taif, western Saudi Arabia. Fifty diarrheal patients without CRF were recruited in the study as controls. Participants were interviewed by a structured questionnaire and stool samples were collected. Samples were thoroughly examined with microscopy and three coproantigens detection kits. Enteric protozoa were detected in 21 cases and 14 controls.Blastocystisspp. were the most predominant parasite (16% in cases versus 8% in controls), followed byGiardia duodenalis(10% in cases versus 12% in controls) andCryptosporidiumspp. (10% in cases versus 6% in controls).Cyclospora cayetanensiswas identified in two cases, whileEntamoeba histolyticawas described in one case and one control. Intestinal parasitism was positively associated with the male gender, urban residence, and travel history. Clinical symptoms of nausea/vomiting and abdominal pain were significantly varied between the parasitized cases and controls (Pvalue≤0.05). Given the results, we recommend screening all diarrheal feces for intestinal protozoa in the study’s population, particularly those with CRF.

scholarly journals FP373CALCIUM PHOSPHATE METABOLISM AND DENTAL STATUS IN HEMODIALYZED PATIENTS WITH CHRONIC RENAL FAILURE

2019 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Beata Jarczewska-Głośnicka ◽  
Anna Kliś ◽  
Iza Maciejewska-Paszek ◽  
Patrycja Paszek ◽  
Tomasz Irzyniec
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Dental Status ◽  
Phosphate Metabolism

scholarly journals Thyroid dysfunctions in patients with chronic renal failure

2017 ◽  
Vol 5 (6) ◽  
pp. 2773
Author(s):  
Ketan Pakhle ◽  
Rushab Parikh ◽  
Ashwini Jain ◽  
Prashant Kashyap ◽  
Dhaval Dave ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Thyroid Dysfunction ◽  
Clinical Symptoms ◽  
Electrolyte Balance ◽  
Laboratory Findings ◽  
Cross Sectional ◽  
Stage Renal Disease ◽  
End Stage ◽  
Tsh Levels

Background: Chronic renal failure (CRF), or end-stage renal disease (ESRD), is a progressive, irreversible deterioration in renal function in which the body’s ability to maintain metabolic and fluid and electrolyte balance fails, resulting in the development of clinical symptoms like uraemia or azotemia. Thyroid hormones have an important role in regulating metabolism, development of the kidney, maintenance of water and electrolyte homeostasis, protein synthesis and influencing other hormone function. Tri-iodothyronine (T3) and thyroxin (T4) are the two main hormones produced by the thyroid. The patients with chronic renal failure often exhibit clinical features and laboratory findings which are indicative of thyroid dysfunction, since, kidney is involved in the metabolism and elimination of TH.Methods: This was a cross sectional single centre descriptive study, including 50 patients of either gender between the age of 45-70 years.Results: Present study found a significant positive correlation between the TSH levels and Zulewski score in patients with CRF.Conclusions: Since there was found to be a correlation between the TSH levels and Zulewski score, the evaluation of symptoms and signs with Zulewski score in addition to thyroid function testing in patients with thyroid dysfunction is essential, since it can be a marker for CRF.

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