Fatty Acid Composition of Serum and Adipose Tissue Lipids in Males with Chronic Renal Failure

The influence of dietary copper on plasma free fatty acid (FFA) levels and the fatty acid composition of adipose tissue lipids was investigated using 24 pigs, fed individually or in groups of six. Barley–fishmeal diets with and without 250 ppm supplemental copper were fed. There were no statistically significant effects on growth or carcass quality due to either dietary copper or method of feeding. There were significant increases (P < 0.001) in the copper content of the liver and kidney of the pigs fed diets containing supplemental copper. Dietary copper increased the proportion of unsaturated fatty acids (UFA) (P < 0.01) in both the total lipid extract and the triglyceride fraction of the outer layer of subcutaneous adipose tissue. Similar but less marked trends were observed in the monoglyceride, diglyceride and FFA fractions. There were significant (P < 0.001) differences between fractions with the FFA fraction having the lowest proportion of the major saturated acids (16:0, 18:0) and the highest proportion of the unsaturated acids (18:1, 18:2). Group feeding increased the proportion of saturated fatty acids. Increases in the concentration of all plasma FFA were observed in the fasting state. Relative proportions of plasma FFA were also significantly different between the fed and fasted state. Females had a significantly higher concentration of FFA than castrated males. Main treatments were without consistent effects on plasma FFA composition or concentration.

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Correlation of fatty acid composition of adipose tissue lipids and serum phosphatidylcholine and serum concentrations of micronutrients with disease duration in rheumatoid arthritis.

Annals of the Rheumatic Diseases ◽

10.1136/ard.49.11.901 ◽

1990 ◽

Vol 49 (11) ◽

pp. 901-905 ◽

Cited By ~ 32

Author(s):

L Jacobsson ◽

F Lindgarde ◽

R Manthorpe ◽

B Akesson

Keyword(s):

Rheumatoid Arthritis ◽

Adipose Tissue ◽

Fatty Acid Composition ◽

Fatty Acid ◽

Acid Composition ◽

Disease Duration ◽

Serum Concentrations ◽

Tissue Lipids

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Rare fatty acids in brown fat are substrates for thermogenesis during arousal from hibernation

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.1989.256.1.r146 ◽

1989 ◽

Vol 256 (1) ◽

pp. R146-R154 ◽

Cited By ~ 7

Author(s):

C. Carneheim ◽

B. Cannon ◽

J. Nedergaard

Keyword(s):

Fatty Acids ◽

Adipose Tissue ◽

Fatty Acid Composition ◽

Fatty Acid ◽

Linoleic Acid ◽

Brown Adipose Tissue ◽

Acid Composition ◽

Brown Fat ◽

Brown Adipose ◽

Tissue Lipids

Because brown adipose tissue lipids are the preferred substrate for thermogenesis during arousal from hibernation, the fatty acid composition of brown fat lipids was followed during cold acclimation and during a hibernation bout. In control golden hamsters (living at 22 degrees C), the fatty acid composition of the white adipose tissue closely resembled that of the food, but brown adipose tissue contained more animal-derived fatty acids. As an effect of acclimation to cold, the fatty acid composition of brown adipose tissue changed to resemble that of the food, and no marked differences between white and brown adipose tissue were then evident. During a hibernation bout, a major part of the fatty acids accumulated in brown fat during entry into hibernation consisted of "rare" acids, such as homo-gamma-linoleic acid. Homo-gamma-linoleic, together with eicosadienoic acid and lignoceric acid, was preferentially utilized during the early phase of arousal. During this phase, "bulk" fatty acids, such as linoleic acid, were spared, whereas in late arousal, linoleic acid was the preferred substrate. It was concluded that rare fatty acids are of quantitative significance in brown adipose tissue during hibernation and arousal.

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Platelet Aggregation in Finnish Men and Its Relation to Fatty Acids in Platelets, Plasma and Adipose Tissue

Thrombosis and Haemostasis ◽

10.1055/s-0038-1660071 ◽

1985 ◽

Vol 54 (03) ◽

pp. 563-569 ◽

Cited By ~ 19

Author(s):

M K Salo ◽

E Vartiainen ◽

P Puska ◽

T Nikkari

Keyword(s):

Fatty Acids ◽

Adipose Tissue ◽

Fatty Acid Composition ◽

Fatty Acid ◽

Platelet Aggregation ◽

Acid Composition ◽

Saturated Fatty Acids ◽

Free Living ◽

Ω3 Fatty Acids ◽

Induced Aggregation

SummaryPlatelet aggregation and its relation to fatty acid composition of platelets, plasma and adipose tissue was determined in 196 randomly selected, free-living, 40-49-year-old men in two regions of Finland (east and southwest) with a nearly twofold difference in the IHD rate.There were no significant east-southwest differences in platelet aggregation induced with ADP, thrombin or epinephrine. ADP-induced platelet secondary aggregation showed significant negative associations with all C20-C22 ω3-fatty acids in platelets (r = -0.26 - -0.40) and with the platelet 20: 5ω3/20: 4ω 6 and ω3/ ω6 ratios, but significant positive correlations with the contents of 18:2 in adipose tissue (r = 0.20) and plasma triglycerides (TG) (r = 0.29). Epinephrine-induced aggregation correlated negatively with 20: 5ω 3 in plasma cholesteryl esters (CE) (r = -0.23) and TG (r = -0.29), and positively with the total percentage of saturated fatty acids in platelets (r = 0.33), but had no significant correlations with any of the ω6-fatty acids. Thrombin-induced aggregation correlated negatively with the ω3/6ω ratio in adipose tissue (r = -0.25) and the 20: 3ω6/20: 4ω 6 ratio in plasma CE (r = -0.27) and free fatty acids (FFA) (r = -0.23), and positively with adipose tissue 18:2 (r = 0.23) and 20:4ω6 (r = 0.22) in plasma phospholipids (PL).The percentages of prostanoid precursors in platelet lipids, i. e. 20: 3ω 6, 20: 4ω 6 and 20 :5ω 3, correlated best with the same fatty acids in plasma CE (r = 0.32 - 0.77) and PL (r = 0.28 - 0.74). Platelet 20: 5ω 3 had highly significant negative correlations with the percentage of 18:2 in adipose tissue and all plasma lipid fractions (r = -0.35 - -0.44).These results suggest that, among a free-living population, relatively small changes in the fatty acid composition of plasma and platelets may be reflected in significant differences in platelet aggregation, and that an increase in linoleate-rich vegetable fat in the diet may not affect platelet function favourably unless it is accompanied by an adequate supply of ω3 fatty acids.

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