scholarly journals Early-onset depressive disorders predict the use of addictive substances in adolescence: a prospective study of adolescent Finnish twins

Addiction ◽  
2008 ◽  
Vol 103 (12) ◽  
pp. 2045-2053 ◽  
Author(s):  
Elina Sihvola ◽  
Richard J. Rose ◽  
Danielle M. Dick ◽  
Lea Pulkkinen ◽  
Mauri Marttunen ◽  
...  
Keyword(s):  
Prospective Study ◽  
Early Onset ◽  
Depressive Disorders ◽  
A Prospective Study

scholarly journals Homocysteine during the third trimester is a risk factor for preeclampsia: A prospective study

2020 ◽  
Author(s):  
Sha Chen ◽  
Hong Shen ◽  
Xueya Zhao ◽  
Jun Luo ◽  
Weiwei Cheng
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Folic Acid ◽  
Prospective Study ◽  
Vitamin B12 ◽  
Early Onset ◽  
Third Trimester ◽  
The Third ◽  
Early Onset Preeclampsia ◽  
A Prospective Study

Abstract Background: The purpose of this study was to investigate the risk factors for elevating homocysteine during pregnancy and the relative effects on preeclampsia, so as to further understand whether Hcy had predictive value for PE.Method: This is a prospective study that only covers pregnant women with singleton who received regular prenatal care from July to September 2018 exclusively at IPMCH (N=1142). Homocysteine, folic acid and vitamin B12 were tested in the 1st trimester (10-14 weeks), 2nd trimester (24-28 weeks), and 3rd trimester (30-34 weeks), respectively, and MTHFR genes (rs1801133, rs1801131, rs17367504) were detected. Therefore, the analysis of this case includes the variation in Hcy levels during pregnancy, risk factors for elevating homocysteine and the risk factors on preeclampsia.Results: (1) Homocysteine was lowest in the 1st trimester. (2) Homocysteine was negatively correlated with folic acid (r=-0.17, p<0.001) and vitamin B12 (r=-0.15, p<0.001) in the same trimester. (3) Both of heterozygous CT (p=0.025, 95% CI 0.018, 0.275) and homozygous TT (p<0.001, 95% CI 0.185, 0.501) in MTHFR rs1801133 might be risk factors that caused an increase in Hcy. G-spot mutations in MTHFR rs17367504 might be a risk factor that caused a decline in homocysteine. (4) Homocysteine in the 3rd trimester might be significantly correlated with increasing risk of preeclampsia (OR = 1.2, 95% CI 1.01,1.42), particularly early-onset preeclampsia (OR = 3.63, 95% CI 1.71,7.71) and severe preeclampsia (OR = 3.63, 95% CI 1.71,7.71).Conclusions: The variation in homocysteine level in the third trimester might be associated with preeclampsia, especially early-onset preeclampsia and severe preeclampsia, and MTHFR, folic acid and vitamin B12 might be the three critical factors responsible for the changing homocysteine levels during pregnancy.

scholarly journals Early-onset tobacco use and suicide-related behavior – A prospective study from adolescence to young adulthood

2018 ◽  
Vol 79 ◽  
pp. 32-38 ◽  
Author(s):  
Tellervo Korhonen ◽  
Elina Sihvola ◽  
Antti Latvala ◽  
Danielle M. Dick ◽  
Lea Pulkkinen ◽  
...  
Keyword(s):  
Prospective Study ◽  
Young Adulthood ◽  
Tobacco Use ◽  
Early Onset ◽  
A Prospective Study

Early onset of hyperkalemia in patients treated with low molecular weight heparin: a prospective study

2004 ◽  
Vol 13 (5) ◽  
pp. 299-302 ◽  
Author(s):  
Maya Koren-Michowitz ◽  
Batia Avni ◽  
Yoav Michowitz ◽  
Gil Moravski ◽  
Shai Efrati ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Prospective Study ◽  
Early Onset ◽  
Low Molecular Weight Heparin ◽  
Low Molecular Weight ◽  
A Prospective Study

scholarly journals Hemorrhagic Disease of Newborn: A Prospective Study of Clinical Features and Outcome.

2018 ◽  
Vol 5 (1) ◽  
pp. 3413-3417
Author(s):  
Dr Ajeet Gopchade
Keyword(s):  
Risk Factors ◽  
Prospective Study ◽  
Clinical Features ◽  
Early Onset ◽  
Late Onset ◽  
Coagulation Factor ◽  
Classical Type ◽  
Hemorrhagic Disease ◽  
Excellent Outcome ◽  
A Prospective Study

Background: Majority of the neonates have a transient deficiency of vitamin K dependant coagulation factors like II, VII, IX and X by 48-72 hours of life. This transient deficiency is resolved by the age of 7-10 days. This transient Vit K dependant coagulation factor deficiency may cause spontaneous bleeding in neonates such bleeding if occurs in between 2nd to 7th day of life is called classical HDN. The other 2 forms of HDN are early onset HDN (Manifesting within 24 hours) and late onset HDN (Occurring between 1-6 months of life). We conducted a prospective study of neonates admitted to our neonatology unit with hemorrhagic disease of newborn to know risk factors and outcome in neonates with HDN. Aims and Objectives: To study the clinical features and outcome of neonates with hemorrhagic disease of newborn. Materials and Methods: This was a prospective cohort study comprising of 30 neonates admitted in NICU with the diagnosis of hemorrhagic disease of newborn. HDN associated risk factors, age at presentation, Demographic profile, clinical features, complications and outcomes were studied. Appropriate statistical analysis was done. P-Value less than 0.05 was taken as statistically significant. Results:  In this study out of 30 neonates diagnosed with hemorrhagic disease of newborn there were 18 (60%) males and 12 (40 %) females with a M:F ratio of 1:0.66. The most common type of HDN was found to be classical type (53.33 %) followed by early onset (12 %) and late HDN (34.77 %). Majority of the infants (83.33%) with HDN were exclusively breastfed and most common site of bleeding were intracranial (23.33 %) and GI bleeding (23.33%). Outcome of neonates showed that 43.33 % babies recovered without any sequele, 13.33 % infants expired and remaining 43.34 % infants had some sequele at the time of discharge. Conclusion: Hemorrhagic disease of newborn is a common cause of bleeding in a well looking baby. Any well looking baby with bleeding manifestations should be considered to be having HDN (early onset, classical or late onset) unless proved otherwise. Appropriate treatment has an excellent outcome in these babies.

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