scholarly journals Homocysteine during the third trimester is a risk factor for preeclampsia: A prospective study

2020 ◽  
Author(s):  
Sha Chen ◽  
Hong Shen ◽  
Xueya Zhao ◽  
Jun Luo ◽  
Weiwei Cheng
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Folic Acid ◽  
Prospective Study ◽  
Vitamin B12 ◽  
Early Onset ◽  
Third Trimester ◽  
The Third ◽  
Early Onset Preeclampsia ◽  
A Prospective Study

Abstract Background: The purpose of this study was to investigate the risk factors for elevating homocysteine during pregnancy and the relative effects on preeclampsia, so as to further understand whether Hcy had predictive value for PE.Method: This is a prospective study that only covers pregnant women with singleton who received regular prenatal care from July to September 2018 exclusively at IPMCH (N=1142). Homocysteine, folic acid and vitamin B12 were tested in the 1st trimester (10-14 weeks), 2nd trimester (24-28 weeks), and 3rd trimester (30-34 weeks), respectively, and MTHFR genes (rs1801133, rs1801131, rs17367504) were detected. Therefore, the analysis of this case includes the variation in Hcy levels during pregnancy, risk factors for elevating homocysteine and the risk factors on preeclampsia.Results: (1) Homocysteine was lowest in the 1st trimester. (2) Homocysteine was negatively correlated with folic acid (r=-0.17, p<0.001) and vitamin B12 (r=-0.15, p<0.001) in the same trimester. (3) Both of heterozygous CT (p=0.025, 95% CI 0.018, 0.275) and homozygous TT (p<0.001, 95% CI 0.185, 0.501) in MTHFR rs1801133 might be risk factors that caused an increase in Hcy. G-spot mutations in MTHFR rs17367504 might be a risk factor that caused a decline in homocysteine. (4) Homocysteine in the 3rd trimester might be significantly correlated with increasing risk of preeclampsia (OR = 1.2, 95% CI 1.01,1.42), particularly early-onset preeclampsia (OR = 3.63, 95% CI 1.71,7.71) and severe preeclampsia (OR = 3.63, 95% CI 1.71,7.71).Conclusions: The variation in homocysteine level in the third trimester might be associated with preeclampsia, especially early-onset preeclampsia and severe preeclampsia, and MTHFR, folic acid and vitamin B12 might be the three critical factors responsible for the changing homocysteine levels during pregnancy.

scholarly journals Homocysteine During the Third Trimester is a Risk Factor for Preeclampsia: A Prospective Study

2020 ◽  
Author(s):  
Sha Chen ◽  
Hong Shen ◽  
Weiwei Cheng ◽  
Xueya Zhao ◽  
Jun Luo
Keyword(s):  
Risk Factors ◽  
Folic Acid ◽  
Prospective Study ◽  
Vitamin B12 ◽  
Early Onset ◽  
Severe Preeclampsia ◽  
Third Trimester ◽  
Pregnancy Risk ◽  
Early Onset Preeclampsia ◽  
A Prospective Study

Abstract Background: The purpose of this study was to investigate the risk factors for elevating homocysteine during pregnancy and the relative effects on preeclampsia.Method: This is a prospective study that only covers pregnant women withsingletonwho received regular prenatal care from July to September 2018 exclusively at IPMCH(N=1142). Homocysteine, folic acid and vitamin B12 were tested in the 1st trimester (10-14 weeks), 2nd trimester (24-28 weeks), and 3rd trimester(30-34 weeks), respectively, and MTHFR genes (rs1801133, rs1801131, rs17367504) were detected. Therefore, the analysis of this case includesthe variation in Hcylevels during pregnancy, risk factors for elevating homocysteine and the risk factors on preeclampsia.Results: (1) Homocysteinewas lowest in the 1st trimester. (2) Homocysteine was negatively correlated with folic acid (r=-0.17, p<0.001) and vitamin B12 (r=-0.15, p<0.001) in the same trimester. (3) Heterozygous CT (p=0.025, 95% CI 0.018,0.275) and homozygous TT (p<0.001, 95% CI 0.185,0.501) in MTHFR rs1801133 both caused an increase inHcy. G-spot mutations in MTHFR rs17367504 caused a decline inhomocysteine. (4) Homocysteine in the 3rd trimester significantly increased the risk of preeclampsia (OR = 1.2, 95% CI 1.01,1.42), particularly early-onset preeclampsia (OR = 3.63, 95% CI 1.71,7.71) and severe preeclampsia (OR = 3.63, 95% CI 1.71,7.71).Conclusions: The variation inhomocysteine level has a direct impact on preeclampsia,especially early-onset preeclampsia and severe preeclampsia, in the3rd trimester, and MTHFR, folic acid and vitamin B12 were the three most critical factors responsible for the changing homocysteine levelsduring pregnancy.

Tobacco use in the third trimester of pregnancy and its relationship to birth weight. A prospective study in Spain

2015 ◽  
Vol 28 (4) ◽  
pp. e134-e139 ◽  
Author(s):  
Rafael Vila Candel ◽  
Francisco J. Soriano-Vidal ◽  
Enrique Hevilla Cucarella ◽  
Enrique Castro-Sánchez ◽  
José M. Martin-Moreno
Keyword(s):  
Birth Weight ◽  
Prospective Study ◽  
Tobacco Use ◽  
Third Trimester ◽  
The Third ◽  
A Prospective Study

HtrA3 Isoform–Specific ELISAs for Early Detection of Preeclampsia

2016 ◽  
Vol 23 (10) ◽  
pp. 1092-1099 ◽  
Author(s):  
Yao Wang ◽  
Ying Li ◽  
Jonathan Hyett ◽  
Fabricio da Silva Costa ◽  
Guiying Nie
Keyword(s):  
Early Detection ◽  
Early Onset ◽  
Late Onset ◽  
Pdz Domain ◽  
First Trimester ◽  
Potential Utility ◽  
Third Trimester ◽  
The Third ◽  
Early Onset Preeclampsia ◽  
Singleton Pregnancies

Preeclampsia is a serious disorder of human pregnancy occurring after 20 weeks of gestation. It can be divided into subtypes of early onset (<34 weeks of gestation) and late onset (>34 weeks). Presymptomatic detection to identify those at high risk is important for managing this disease. HtrA3, a serine protease with high expression in the developing placenta, exists in long (HtrA3-L) and short (HtrA3-S) isoforms. They are identical, except HtrA3-S lacks the C-terminal PDZ domain. We have previously shown by Western blot analysis that serum HtrA3 levels at the end of the first trimester are significantly higher in women who later develop preeclampsia than in controls. In this study, using highly specific HtrA3 monoclonal antibodies, we established and fully validated two enzyme-linked immunosorbent assays to detect both HtrA3 isoforms together (HtrA3-T) and HtrA3-L alone in the human serum. We then determined serum HtrA3 at 11 to 13 weeks of gestation in a cohort of singleton pregnancies that proceeded without complications or developed preeclampsia in the third trimester. Compared with controls, those who developed late-onset preeclampsia had significantly higher levels of HtrA3-L, whereas those who developed early-onset preeclampsia had significantly lower ratios of HtrA3-L/HtrA3-T. These data support a potential utility of these HtrA3 ELISAs for early detection of preeclampsia.

scholarly journals Gambaran Faktor Risiko pada Wanita Hamil Trimester 3 yang Terkonfirmasi Positif SARS-CoV-2

2021 ◽  
Vol 9 (2) ◽  
Author(s):  
Aurelia S. Posumah ◽  
Mayer F. Wowor ◽  
Glady I. Rambert
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Severe Acute Respiratory Syndrome ◽  
Pregnant Women ◽  
Close Contact ◽  
Secondary Data ◽  
Third Trimester ◽  
Travel History ◽  
The Third ◽  
Diabetes Melitus

Abstract: Coronavirus Disease 2019 (COVID-19) a infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). There are several groups that are susceptible to infection with SARS-CoV-2, one of which is pregnant women. This can be attributed to changes in the physiology and immune system that occur in pregnant women. This study aimed to determine the most risk factors that cause pregnant women in Prof. Dr. R. D. Kandou was infected with SARS-CoV-2. This type of research is descriptive with a retrospective approach, using secondary data in the form of data from the patient's medical record status. From 5 patients studied, there were 4 patients with risk factors for hypertension (80%) and 1 patient with close contact risk factors (20%), but other risk factors such as diabetes mellitus, travel history in transmission areas, obesity and smoking are not found. In conclusion, from 5 patients studied, the most risk factor that causes pregnant women in the third trimester to be infected with SARS-CoV-2 is hypertension (80%).Keywords: 3rd trimester pregnant women, SARS-CoV-2, risk factor  Abstrak: Coronavirus Disease 2019 (COVID-19) penyakit menular yang disebabkan oleh Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Terdapat beberapa kelompok yang rentan terinfeksi SARS-CoV-2, salah satunya wanita hamil. Hal ini dapat dikaitkan dengan perubahan fisiologi dan sistem imunitas tubuh yang terjadi pada wanita hamil. Tujuan penelitian ini untuk mengetahui faktor risiko terbanyak yang menyebabkan wanita hamil di RSUP Prof. Dr. R. D. Kandou terinfeksi SARS-CoV-2. Jenis penelitian yang digunakan bersifat deskriptif dengan pendekatan retrospektif, yaitu menggunakan data sekunder berupa data dari status rekam medik pasien. Dari 5 pasien yang diteliti, didapatkan 4 pasien dengan faktor risiko hipertensi (80%) dan 1 pasien dengan faktor risiko kontak erat (20%), namun pada faktor risiko lain seperti diabetes melitus, riwayat perjalanan di daerah transmisi, obesitas dan merokok tidak ditemukan. Sebagai simpulan, dari 5 pasien yang diteliti, faktor risiko terbanyak yang menyebabkan wanita hamil trimester 3 terinfeksi SARS-CoV-2 adalah hipertensi (80%).Kata Kunci: wanita hamil trimester 3, SARS-CoV-2, faktor risiko

scholarly journals Hemorrhagic Disease of Newborn: A Prospective Study of Clinical Features and Outcome.

2018 ◽  
Vol 5 (1) ◽  
pp. 3413-3417
Author(s):  
Dr Ajeet Gopchade
Keyword(s):  
Risk Factors ◽  
Prospective Study ◽  
Clinical Features ◽  
Early Onset ◽  
Late Onset ◽  
Coagulation Factor ◽  
Classical Type ◽  
Hemorrhagic Disease ◽  
Excellent Outcome ◽  
A Prospective Study

Background: Majority of the neonates have a transient deficiency of vitamin K dependant coagulation factors like II, VII, IX and X by 48-72 hours of life. This transient deficiency is resolved by the age of 7-10 days. This transient Vit K dependant coagulation factor deficiency may cause spontaneous bleeding in neonates such bleeding if occurs in between 2nd to 7th day of life is called classical HDN. The other 2 forms of HDN are early onset HDN (Manifesting within 24 hours) and late onset HDN (Occurring between 1-6 months of life). We conducted a prospective study of neonates admitted to our neonatology unit with hemorrhagic disease of newborn to know risk factors and outcome in neonates with HDN. Aims and Objectives: To study the clinical features and outcome of neonates with hemorrhagic disease of newborn. Materials and Methods: This was a prospective cohort study comprising of 30 neonates admitted in NICU with the diagnosis of hemorrhagic disease of newborn. HDN associated risk factors, age at presentation, Demographic profile, clinical features, complications and outcomes were studied. Appropriate statistical analysis was done. P-Value less than 0.05 was taken as statistically significant. Results:  In this study out of 30 neonates diagnosed with hemorrhagic disease of newborn there were 18 (60%) males and 12 (40 %) females with a M:F ratio of 1:0.66. The most common type of HDN was found to be classical type (53.33 %) followed by early onset (12 %) and late HDN (34.77 %). Majority of the infants (83.33%) with HDN were exclusively breastfed and most common site of bleeding were intracranial (23.33 %) and GI bleeding (23.33%). Outcome of neonates showed that 43.33 % babies recovered without any sequele, 13.33 % infants expired and remaining 43.34 % infants had some sequele at the time of discharge. Conclusion: Hemorrhagic disease of newborn is a common cause of bleeding in a well looking baby. Any well looking baby with bleeding manifestations should be considered to be having HDN (early onset, classical or late onset) unless proved otherwise. Appropriate treatment has an excellent outcome in these babies.

Cold Weather Training: A Risk Factor for Achilles Paratendinitis among Recruits

2003 ◽  
Vol 24 (5) ◽  
pp. 398-401 ◽  
Author(s):  
C. Milgrom ◽  
A. Finestone ◽  
D. Zin ◽  
D. Mandel ◽  
V. Novack
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Prospective Study ◽  
Achilles Tendinopathy ◽  
Cold Weather ◽  
Increased Risk ◽  
A Prospective Study ◽  
Outdoor Training

In a prospective study of risk factors for Achilles tendinopathy among four induction cycles of infantry recruits, 95 out of 1405 recruits, (6.8%) were found to suffer from Achilles tendinopathy. In more than 94% of the cases, the tendinopathy was considered to be paratendinitis. Training season had a statistically significant effect on the incidence of Achilles paratendinitis with 3.6% suffering in the summer and 9.4% in the winter ( p = .001). This increased risk for Achilles paratendinitis in cold weather outdoor training can be explained by a fall in temperature of the Achilles paratenon whose membranes are rich in mucopolysaccharides and serve as a lubricant for gliding of the tendon and epitenon. Decreased temperature may increase the viscosity of the lubricant and thereby increases friction and risk for Achilles paratendinitis. This same relationship illustrates why “warming up” before exercising may be important in lowering the incidence of Achilles paratendinitis.

scholarly journals Incidence and risk factors associated with ectopic pregnancy: a prospective study

2021 ◽  
Author(s):  
Harish K. M. ◽  
Shwetha N. ◽  
Nalini N.
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Prospective Study ◽  
Ectopic Pregnancy ◽  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Tertiary Care ◽  
Care Hospital ◽  
History Of ◽  
A Prospective Study

Background: Increased incidence of ectopic pregnancy and its impact on women’s fertility in recent years need significant attention.Methods: A two years prospective study from January 2018 to December 2019 conducted to determine incidence, association of risk factors with ectopic pregnancy and find the most common risk factor of ectopic pregnancy in department of obstetrics and Gynaecology, a tertiary care Hospital in Pune.Results: During the study period 100 patients were diagnosed to have ectopic pregnancy. Incidence was 5.29 per 1000 births. Majority were in the age group of 20-24 years (42%), multiparous (59%) and belong to low socioeconomic state (62%). In majority of the patients (22%) no risk factors was found. Among the patients who had risk factors, the main risk factors for ectopic pregnancy were history of history of pelvic inflammatory disease (20%), previous tubal/abdominal surgery (12%), history of Infertility (10%), previous termination of pregnancy (10%), contraception with mirena IUS or IUCD in situ (8%) and a history of prior ectopic pregnancy (4%).Conclusions: In majority (78%) of patients risk factors for ectopic pregnancy was present and pelvic inflammatory disease was found to be a major risk factor for ectopic pregnancy.

scholarly journals BIOFACE: A prospective study of risk factors, cognition and biomarkers in a cohort of individuals with early‐onset mild cognitive impairment at Fundació ACE

2021 ◽  
Vol 17 (S5) ◽  
Author(s):  
Ester Esteban‐De Antonio ◽  
Alba Pérez‐Cordón ◽  
Silvia Gil ◽  
Amanda Cano ◽  
Adelina Orellana ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Prospective Study ◽  
Early Onset ◽  
A Prospective Study
Sign in / Sign up

Export Citation Format

Share Document