Review article: multimodality treatment of liver metastases increases suitability for surgical treatment

e14534 Background: Pts with synchronous PC and LM are generally considered for exclusive systemic palliative chemotherapy only. Aggressive surgical approaches combining hepatectomy associated to peritoneal resection with curative intent remain controversial in such a setting and almost no data are available on such patients.The aim of this prospective cohort was to assess morbidity, mortality, disease-free survival (DFS) and overall survival (OS) of peritoneal and liver mCRC patients (pts) treated with an aggressive therapeutic approach combining surgical treatment of liver and peritoneal lesions followed by HIPEC. Methods: All patients registered in the French Association of Surgeryprospective database with PC and synchronous LM who had undergone cytoreductive surgery and LM resection followed by intraperitoneal chemotherapy were analysed. The primary endpoint was survival from the time of surgery. The following criteria were recorded and analyzed: sex, age, differentiation and localization of the primary tumor, lymph node involvement (pN+), peritoneal cancer index (PCI), completeness of cytoreduction of peritoneal carcinomatosis, number of associated liver metastases. Results: From 1993 to 2011, 101 pts with PC and LM were analyzed. After a mean follow-up of 25 months, the median OS and DFS, were respectively 24.9 and 9.5 months. Post-operative morbidity and mortality was 14.8 and 0%, respectively. In pts with a complete cytoreductive surgery OS was 29 months (n=), as compared to 4 months in pts (n=) with incomplete cytoreduction (p=0.0001). Rectal primary tumor, PCI of 13 or more, pN+ status, and more than 3 LM were not identified as independent factors for poor OS. Conclusions: This multicenter study confirms that prolonged survival can be achieved in selected patients suitable for PC and LM surgery if they underwent multimodality treatment including surgical treatment of PC and LM with curative intent, using intraperitoneal chemotherapy.

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Integrating Systemic Therapies into the Multimodality Treatment of Resectable Colorectal Liver Metastases

Gastroenterology Research and Practice ◽

10.1155/2018/4326082 ◽

2018 ◽

Vol 2018 ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

Omar Abdel-Rahman ◽

Winson Y. Cheung

Keyword(s):

Liver Metastases ◽

Management Strategy ◽

Multimodality Treatment ◽

Treatment Modalities ◽

Considerable Proportion ◽

Optimal Management ◽

Related Factors ◽

Multiple Treatment ◽

Current Review ◽

Systemic Therapies

Colorectal carcinoma (CRC) is one of the most common cancers worldwide. A considerable proportion of CRC patients may present with metastatic disease either at upfront presentation (synchronous with the primary) or following diagnosis and treatment of the primary tumor (metachronous). Management of CRC liver metastases is a challenging endeavor which frequently necessitates proper assessment of patient- and disease-related factors. There is an opportunity within the management of CRC liver metastases to incorporate multiple treatment modalities (including surgery, other locoregional treatments, and systemic therapy). The current review aims to provide an updated overview on the optimal management strategy for CRC patients with liver metastases with a specific focus on the integration of systemic and/or locoregional treatments among patients with resectable or potentially resectable disease.

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Surgical treatment of tandem stenosis of the internal carotid artery

Patologiya krovoobrashcheniya i kardiokhirurgiya ◽

10.21688/1681-3472-2021-3-20-26 ◽

2021 ◽

Vol 25 (3) ◽

pp. 20

Author(s):

A. D. Pryamikov ◽

A. B. Mironkov ◽

A. I. Khripun

Keyword(s):

Surgical Treatment ◽

Carotid Artery ◽

Internal Carotid Artery ◽

World Literature ◽

Large Scale ◽

Internal Carotid ◽

Review Article ◽

Conflicts Of Interests ◽

Tandem Stenosis ◽

Instrumental Methods

This review article presents an analysis of the world literature devoted to treating patients with tandem stenosis of the intra- and extra-cranial parts of the internal carotid artery. We indicate the frequency of tandem lesion occurrence and describe the applied instrumental methods of its diagnosis. The review demonstrates the results of tandem stenosis surgical treatment in both early and more modern studies and describes the possibilities of endovascular correction of extra- and intra-cranial stenosis of the internal carotid artery. The authors emphasise the lack of large-scale studies — including randomised studies — regarding combined, tandem carotid stenosis and the need for further studies.Received 30 March 2021. Revised 8 May 2021. Accepted 11 May 2021.Funding: The study did not have sponsorship.Conflict of interest: The authors declare no conflicts of interests.Contribution of the authors: The authors contributed equally to this article.

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Surgical Treatment and Other Regional Treatments for Colorectal Cancer Liver Metastases

The Oncologist ◽

10.1634/theoncologist.4-3-197 ◽

1999 ◽

Vol 4 (3) ◽

pp. 197-208 ◽

Cited By ~ 85

Author(s):

Sam S. Yoon ◽

Kenneth K. Tanabe

Keyword(s):

Colorectal Cancer ◽

Surgical Treatment ◽

Liver Metastases ◽

Colorectal Cancer Liver Metastases

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Atrial fibrillation surgery with a focus on patients with reduced left ventricular function and heart failure

EP Europace ◽

10.1093/europace/euaa016 ◽

2020 ◽

Vol 22 (4) ◽

pp. 517-521

Author(s):

Johannes Petersen ◽

Hermann Reichenspurner ◽

Simon Pecha

Keyword(s):

Heart Failure ◽

Atrial Fibrillation ◽

Surgical Treatment ◽

Left Ventricular Function ◽

Treatment Options ◽

Left Ventricular ◽

Review Article ◽

Surgical Ablation ◽

Ablation Therapy ◽

Patients With Heart Failure

Abstract This review article aims to give an overview on the different surgical treatment options for atrial fibrillation It includes concomitant- as well as stand-alone surgical ablation therapy and outlines the main issues in patients with heart failure and reduced LVEF.

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Socioeconomic determinants of the surgical treatment of colorectal liver metastases

The American Journal of Surgery ◽

10.1016/j.amjsurg.2020.02.019 ◽

2020 ◽

Vol 220 (4) ◽

pp. 952-957

Author(s):

Naomi M. Sell ◽

Neha Shafique ◽

Hang Lee ◽

Grace C. Lee ◽

Kenneth K. Tanabe ◽

...

Keyword(s):

Surgical Treatment ◽

Liver Metastases ◽

Colorectal Liver Metastases ◽

Socioeconomic Determinants

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Disparities in the Surgical Treatment of Colorectal Liver Metastases

Journal of the National Medical Association ◽

10.1016/s0027-9684(15)30112-7 ◽

2013 ◽

Vol 105 (2) ◽

pp. 128-137 ◽

Cited By ~ 7

Author(s):

Gitonga Munene ◽

Robyn D. Parker ◽

Abdel Aziz Shaheen ◽

Robert P. Myers ◽

May Lynn Quan ◽

...

Keyword(s):

Surgical Treatment ◽

Liver Metastases ◽

Colorectal Liver Metastases

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Percutaneous Management of Enterocutaneous Fistulae and Abscess–Fistula Complexes

Digestive Disease Interventions ◽

10.1055/s-0038-1660452 ◽

2018 ◽

Vol 02 (02) ◽

pp. 131-140 ◽

Cited By ~ 4

Author(s):

Abigail Erickson ◽

Chaitanya Ahuja ◽

Romulo Vea ◽

Guillermo Sangster ◽

Horacio D'Agostino ◽

...

Keyword(s):

Surgical Treatment ◽

Percutaneous Drainage ◽

Treatment Options ◽

Management Strategies ◽

Treatment Strategies ◽

Review Article ◽

Abdominal Abscesses ◽

Percutaneous Catheter

AbstractAbscess–fistula complexes and enterocutaneous fistulae are due to postoperative, spontaneous, and inflammatory etiologies. Conservative, percutaneous, endoscopic, and surgical treatment options are available options. Interventional radiologists have an array of different treatment strategies, often starting with percutaneous drainage of associated intra-abdominal abscesses. This review article details different percutaneous management strategies, focusing on percutaneous catheter strategies for abscess-fistula complexes along with tract closures strategies for enterocutaneous fistulae.

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