Sunlight or diet: what is the answer for providing sufficient vitamin D in the U.K.?: reply from author

Abstract Novel coronavirus disease 2019 (COVID-19) has spread to > 10 000 000 individuals in a short time. With no pharmacological agents successfully implemented to control the outbreak, the use of less invasive nonpharmacological agents, such as vitamin D, are increasingly being studied. This purpose of this article is to determine the current knowledge about the risk of COVID-19 development for populations at risk for vitamin D deficiency, including individuals living with overweight and obesity, those of older age, and racial or ethnic minorities. Despite the documented impact of vitamin D on viral disease prevention, many subgroups at risk for contracting COVID-19 are also known to have increased rates of vitamin D deficiency. Because vitamin D is most commonly obtained from sunlight, when interpreted alongside the stay-at-home orders, the importance of identifying safe approaches to obtain sufficient vitamin D is apparent. Furthermore, elucidating the cause-and-effect relationship between vitamin D and COVID-19, including optimal dosing for COVID-19 outcomes, is also warranted for immediate investigation.

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Assessment of Vitamin D3 Levels and Metabolic Profile in Pre-diabetic and Type 2 Diabetes Mellitus Patient of Kanpur City- A Cross Sectional Study

Iranian journal of diabetes and obesity ◽

10.18502/ijdo.v12i1.3632 ◽

2020 ◽

Author(s):

Prashant Tripathi ◽

Malvika Mishra ◽

Kirti Amresh Gautam ◽

Arisht Jain ◽

Saurabh Agarwal

Keyword(s):

Vitamin D ◽

Glycemic Control ◽

Vitamin D3 ◽

Cross Sectional Study ◽

P Value ◽

Sectional Study ◽

Good Glycemic Control ◽

Cross Sectional ◽

Hba1 C ◽

Sufficient Vitamin

Objective: It has been explored that Vitamin D play role in various non-skeletal disorders including Diabetes Mellitus. The present study was designed with the aim to assess association among control, pre-diabetic and diabetic with vitamin D and association between lipid profile and vitamin D. Materials and Methods: A total of 109 subjects were recruited for the cross-sectional study including 37 as control, 41 pre-diabetic and 31 diabetic. A clinical examination was done for all the groups including fasting samples (12hrs) for lipid parameters, serum 25 (OH) vitamin D level and (HbA1/C). Results: It was found that in control subjects 37.9% have the sufficient vitamin D3 level whereas 17.1% subjects in pre-diabetic, 16.6% in diabetic with good glycemic control and no subject was found to have sufficient vitamin D3 level in diabetic with poor glycemic control. The mean vitamin D3 levels was highest in control i.e. -26.53±11.99 ng/ml followed by 20.23±4.12ng/ml in prediabetics,19.07±8.01ng/ml in diabetics with good glycemic control and 12.92±6.77ng/ml in diabetics with poor glycemic control. HBA1/c and serum vitamin D3level share a significant association (P-value< 0.01).Total cholesterol (P-value< 0.0), serum triglyceride (P-value< 0.01), serum LDL cholesterol (P-value< 0.01) and serum VLDL (P-value< 0.01) had inverse association with vitamin D levels. HDL cholesterol has no effect with vitamin D. Conclusion: The present study showed vitamin D3 deficiency as a risk factor for worsening glycemic control and dyslipidemia.

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Vitamin D levels in pregnant women in Uttarakhand, India

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20175840 ◽

2017 ◽

Vol 7 (1) ◽

pp. 169

Author(s):

Nikita Pahuja ◽

Nidhi Chauhan ◽

Vinita Kalra

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Bone Growth ◽

Innate Immune ◽

Vitamin D Status ◽

Medical Sciences ◽

Healthy Pregnancy ◽

Vitamin D Levels ◽

Increase Risk ◽

Sufficient Vitamin

Background: A balanced, nutritious diet is an important aspect of a healthy pregnancy and its outcome. Vitamin D plays an important role in regular bone growth and in adequate function of innate immune system, including barrier function of mucous membrane. Vitamin D deficiency in adult females may increase risk of pre-eclampsia, gestational diabetes, bacterial vaginosis. The present study was undertaken to find the prevalence of Vitamin D deficiency in the women of Uttarakhand, India.Methods: The study was conducted in the Department of Obstetrics and Gynecology, Himalayan Institute of Medical Sciences (HIMS), Swami Ram Nagar, Dehradun, India over a period of 12 months. Sample size was 100 pregnant females attending antenatal clinic.Results: Out of 100 subjects, 21 (21%) had deficient, 69 (69%) had insufficient and 10 (10%) had sufficient vitamin D status. Out of 21 deficient subjects, 18 (85.71%) were Hindus, 2 (9.52%) were Muslims, 1 (4.76%) was Sikh and no deficiency was seen in Christian. In the present study, deficient vitamin D status was seen in 1 (4.76%) in lower, 16 (76.19%) in middle and 4 (19.04%) subjects in upper socioeconomic status.Conclusions: It is concluded from our study that there is serious vitamin D deficiency and insufficiency in the women of Uttarakhand, India.

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Author response for "In infants with sufficient vitamin D status at birth, vitamin D supplementation does not impact immune development"

10.1111/pai.13250/v2/response1 ◽

2020 ◽

Author(s):

Jonatan Leffler ◽

Cristina Gamez ◽

Anderson P. Jones ◽

Kristina Rueter ◽

James F. Read ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Supplementation ◽

Author Response ◽

Vitamin D Status ◽

Immune Development ◽

Sufficient Vitamin

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Decision letter for "In infants with sufficient vitamin D status at birth, vitamin D supplementation does not impact immune development"

10.1111/pai.13250/v1/decision1 ◽

2020 ◽

Keyword(s):

Vitamin D ◽

Vitamin D Supplementation ◽

Vitamin D Status ◽

Immune Development ◽

Sufficient Vitamin

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Meta-analysis of vitamin D and lung function in patients with asthma

Respiratory Research ◽

10.1186/s12931-019-1072-4 ◽

2019 ◽

Vol 20 (1) ◽

Cited By ~ 8

Author(s):

Jian Liu ◽

Yong-Quan Dong ◽

Jie Yin ◽

Jian Yao ◽

Jie Shen ◽

...

Keyword(s):

Vitamin D ◽

Lung Function ◽

Meta Analysis ◽

Serum Vitamin ◽

Forced Expiratory Volume ◽

Asthma Control Test ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Asthma Patients ◽

Sufficient Vitamin

Abstract Background There is growing literature suggesting a link between vitamin D and asthma lung function, but the results from systematic reviews are conflicting. We conducted this meta-analysis to investigate the relation between serum vitamin D and lung function in asthma patients. Methods Major databases, including OVID, MEDLINE, Web of Science and PUBMED, were searched until 10th October 2018. All published observational studies related to vitamin D and asthma were extracted. All meta-analyses were performed using Review Manager 5.3.5. Results This quantitative synthesis found that asthma patients with low vitamin D levels had lower forced expiratory volume In 1 s (FEV1) (mean difference (MD) = − 0.1, 95% CI = − 0.11 to − 0.08,p < 0.01;I2 = 49%, p = 0.12) and FEV1% (MD = − 10.02, 95% CI = − 11 to − 9.04, p < 0.01; I2 = 0%, p = 0.82) than those with sufficient vitamin D levels. A positive relation was found between vitamin D and FEV1 (r = 0.12, 95% CI = 0.04 to 0.2, p = 0.003; I2 = 59%,p = 0.01), FEV1% (r = 0.19, 95% CI = 0.13 to 0.26, p < 0.001; I2 = 42%, p = 0.11), forced vital capacity (FVC) (r = 0.17, 95% CI = 0.00 to 0.34, p = 0.05; I2 = 60%, p = 0.04), FEV1/FVC (r = 0.4, 95% CI = 0.3 to 0.51, p < 0.001; I2 = 48%, p = 0.07), and the asthma control test (ACT) (r = 0.33, 95% CI = 0.2 to 0.47, p < 0.001; I2 = 0%, p = 0.7). Subgroup analysis indicated that the positive correlation between vitamin D and lung function remained significant in both children and adults. Conclusions Our meta-analysis suggested that serum vitamin D levels may be positively correlated with lung function in asthma patients. Future comprehensive studies are required to confirm these relations and to elucidate potential mechanisms.

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