Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children

2009 ◽  
Vol 39 (6) ◽  
pp. 875-882 ◽  
Author(s):  
M. Erkkola ◽  
M. Kaila ◽  
B. I. Nwaru ◽  
C. Kronberg-Kippilä ◽  
S. Ahonen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Allergic Rhinitis ◽  
Maternal Vitamin ◽  
Vitamin D Intake

scholarly journals Maternal Vitamin D and Newborn Telomere Length

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2012
Author(s):  
Lisa Daneels ◽  
Dries S. Martens ◽  
Soumia Arredouani ◽  
Jaak Billen ◽  
Gudrun Koppen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cord Blood ◽  
Telomere Length ◽  
First Trimester ◽  
Maternal Serum ◽  
Adverse Outcomes ◽  
Dietary Vitamin ◽  
Maternal Vitamin ◽  
Vitamin D Intake ◽  
Diet Supplements

Nutrition is important during pregnancy for offspring health. Gestational vitamin D intake may prevent several adverse outcomes and might have an influence on offspring telomere length (TL). In this study, we want to assess the association between maternal vitamin D intake during pregnancy and newborn TL, as reflected by cord blood TL. We studied mother–child pairs enrolled in the Maternal Nutrition and Offspring’s Epigenome (MANOE) cohort, Leuven, Belgium. To calculate the dietary vitamin D intake, 108 women were asked to keep track of their diet using the seven-day estimated diet record (EDR) method. TL was assessed in 108 cord blood using a quantitative real-time PCR method. In each trimester of pregnancy, maternal serum 25-hydroxyvitamin D (25-OHD) concentration was measured. We observed a positive association (β = 0.009, p-value = 0.036) between newborn average relative TL and maternal vitamin D intake (diet + supplement) during the first trimester. In contrast, we found no association between average relative TL of the newborn and mean maternal serum 25-OHD concentrations during pregnancy. To conclude, vitamin D intake (diet + supplements), specifically during the first trimester of pregnancy, is an important factor associated with TL at birth.

scholarly journals Maternal vitamin D intake during pregnancy and early childhood wheezing

2007 ◽  
Vol 85 (3) ◽  
pp. 853-859 ◽  
Author(s):  
Graham Devereux ◽  
Augusto A Litonjua ◽  
Stephen W Turner ◽  
Leone CA Craig ◽  
Geraldine McNeill ◽  
...  
Keyword(s):  
Vitamin D ◽  
Early Childhood ◽  
Maternal Vitamin ◽  
Vitamin D Intake

scholarly journals Maternal vitamin D intake and mineral metabolism in mothers and their newborn infants.

BMJ ◽  
1980 ◽  
Vol 281 (6232) ◽  
pp. 11-14 ◽  
Author(s):  
F Cockburn ◽  
N R Belton ◽  
R J Purvis ◽  
M M Giles ◽  
J K Brown ◽  
...  
Keyword(s):  
Vitamin D ◽  
Mineral Metabolism ◽  
Newborn Infants ◽  
Maternal Vitamin ◽  
Vitamin D Intake

scholarly journals Predicted vitamin D status during pregnancy in relation to offspring forearm fractures in childhood: a study from the Danish National Birth Cohort

2015 ◽  
Vol 114 (11) ◽  
pp. 1900-1908 ◽  
Author(s):  
Sesilje B. Petersen ◽  
Marin Strøm ◽  
Ekaterina Maslova ◽  
Charlotta Granström ◽  
Peter Vestergaard ◽  
...  
Keyword(s):  
Vitamin D ◽  
Birth Cohort ◽  
Dietary Vitamin ◽  
Vitamin D Status ◽  
Forearm Fractures ◽  
Maternal Vitamin ◽  
Vitamin D Intake ◽  
Danish National Birth Cohort ◽  
Tanning Bed ◽  
Maternal Vitamin D Status

AbstractIn a prospective cohort study, the association between maternal vitamin D status during pregnancy and offspring forearm fractures during childhood and adolescence was analysed in 30 132 mother and child pairs recruited to the Danish National Birth Cohort between 1996 and 2002. Data on characteristics, dietary factors and lifestyle factors were collected on several occasions during pregnancy. We analysed the association between predicted vitamin D status, based on a subsample with 25-hydroxyvitamin D (25(OH)D) biomarker measurements (n 1497) from gestation week 25, and first-time forearm fractures among offspring between birth and end of follow-up. Diagnoses were extracted from the Danish National Patient Register. Multivariable Cox regression models using age as the underlying time scale indicated no overall association between predicted vitamin D status (based on smoking, season, dietary and supplementary vitamin D intake, tanning bed use and outdoor physical activity) in pregnancy and offspring forearm fractures. Likewise, measured 25(OH)D, tanning bed use and dietary vitamin D intake were not associated with offspring forearm fractures. In mid-pregnancy, 91 % of the women reported intake of vitamin D from dietary supplements. Offspring of women who took >10 µg/d in mid-pregnancy had a significantly increased risk for fractures compared with the reference level of zero intake (hazard ratios (HR) 1·31; 95 % CI 1·06, 1·62), but this was solely among girls (HR 1·48; 95 % CI 1·10, 2·00). Supplement use in the peri-conceptional period exhibited similar pattern, although not statistically significant. In conclusion, our data indicated no protective effect of maternal vitamin D status with respect to offspring forearm fractures.

scholarly journals Maternal vitamin D intake and BMI during pregnancy in relation to child’s growth and weight status from birth to 8 years: a large national cohort study

BMJ Open ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. e048980
Author(s):  
Anna Amberntsson ◽  
Eleni Papadopoulou ◽  
Anna Winkvist ◽  
Lauren Lissner ◽  
Helle Margrete Meltzer ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Weight Status ◽  
Childhood Overweight ◽  
Normal Weight ◽  
Anthropometric Measurement ◽  
Lower Odds ◽  
Maternal Vitamin ◽  
Vitamin D Intake ◽  
Weight Growth

ObjectivesTo examine the associations between maternal vitamin D intake and childhood growth and risk of overweight up to 8 years. We further examined the effect modification by maternal prepregnancy body mass index (BMI).DesignProspective population-based pregnancy cohort study.SettingThe Norwegian Mother, Father and Child Cohort Study.ParticipantsIn total, 58 724 mothers and 66 840 singleton children, with information on maternal vitamin D intake during the pregnancy and minimum one postnatal anthropometric measurement.Outcome measuresPredicted weight and height growth trajectories and velocities from 1 month to 8 years, rapid growth during infancy and toddlerhood, and risk of overweight in preschool and school age.ResultsOverall, maternal vitamin D intake was associated with lower weight trajectory, lower odds of rapid weight growth and higher odds of childhood overweight. In children of mothers with prepregnancy normal weight, maternal vitamin D intake was negatively associated with weight trajectory and lower OR of a rapid weight growth during the first year, compared with reference (<5 µg/day). Children of mothers with normal weight, with maternal vitamin D intakes of 10–15 and >15 µg/day, also had 0.86 (95% CI 0.77 to 0.97) and 0.88 (95% CI 0.79 to 0.99) lower odds for overweight at 3 years, compared with reference. In contrast, in children of mothers with prepregnancy overweight (BMI ≥25 kg/m2), vitamin D intake was positively associated with weight trajectory. Children of mothers with overweight, with maternal vitamin D intake of 5–9.9 µg/day, also had (1.09 (95% CI 1.01 to 1.18) and 1.12 (95% CI 1.02 to 1.23)) higher odds for overweight at 5 years and 8 years, compared with reference.ConclusionsMaternal vitamin D intake affects postnatal growth and is inversely associated with childhood overweight in children of mothers with normal weight. Associations between maternal vitamin D intake and child growth and risk of overweight varied by prepregnancy BMI.

scholarly journals Maternal vitamin D and E intakes during pregnancy are associated with asthma in children

2014 ◽  
Vol 45 (4) ◽  
pp. 1027-1036 ◽  
Author(s):  
Keith M. Allan ◽  
Nanda Prabhu ◽  
Leone C.A. Craig ◽  
Geraldine McNeill ◽  
Bradley Kirby ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin E ◽  
Maternal Plasma ◽  
Longitudinal Analyses ◽  
Standard Deviation Increase ◽  
Maternal Vitamin ◽  
Negatively Associated ◽  
Vitamin D Intake ◽  
Increased Risk ◽  
Significant Public Health

Are maternal vitamin D and E intakes during pregnancy associated with asthma in 10-year-old children?In a longitudinal study of 1924 children born to women recruited during pregnancy, maternal vitamin D intake during pregnancy was assessed by the Food Frequency Questionnaire (FFQ) and vitamin E by FFQ and plasma α-tocopherol; respiratory questionnaires were completed for the 10-year-old children. Their treatment for asthma was also ascertained using administrative data. Longitudinal analyses included data collected at 1, 2, 5 and 10 years.Symptom data were available for 934 (49%) children and use of asthma medication for 1748 (91%). In the children maternal vitamin D intake during pregnancy was negatively associated with doctor-diagnosed asthma at 10 years of age (OR per intake quintile 0.86, 95% CI 0.74–0.99) and over the first 10 years (hazard ratio 0.90, 95% CI 0.81–1.00). Maternal plasma α-tocopherol at 11 weeks gestation was negatively associated with children receiving asthma treatment (OR per standard deviation increase 0.52, 95% CI 0.31–0.87). Maternal vitamin E intake was negatively associated with doctor-diagnosed asthma (OR 0.89, 95% CI 0.81–0.99) in the first 10 years.Low maternal vitamin D and E intakes during pregnancy are associated with increased risk of children developing asthma in the first 10 years of life. These associations may have significant public health implications.

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