Maternal vitamin D intake during pregnancy increases gene expression of ILT3 and ILT4 in cord blood

Nutrition is important during pregnancy for offspring health. Gestational vitamin D intake may prevent several adverse outcomes and might have an influence on offspring telomere length (TL). In this study, we want to assess the association between maternal vitamin D intake during pregnancy and newborn TL, as reflected by cord blood TL. We studied mother–child pairs enrolled in the Maternal Nutrition and Offspring’s Epigenome (MANOE) cohort, Leuven, Belgium. To calculate the dietary vitamin D intake, 108 women were asked to keep track of their diet using the seven-day estimated diet record (EDR) method. TL was assessed in 108 cord blood using a quantitative real-time PCR method. In each trimester of pregnancy, maternal serum 25-hydroxyvitamin D (25-OHD) concentration was measured. We observed a positive association (β = 0.009, p-value = 0.036) between newborn average relative TL and maternal vitamin D intake (diet + supplement) during the first trimester. In contrast, we found no association between average relative TL of the newborn and mean maternal serum 25-OHD concentrations during pregnancy. To conclude, vitamin D intake (diet + supplements), specifically during the first trimester of pregnancy, is an important factor associated with TL at birth.

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Faculty Opinions recommendation of Maternal vitamin D intake during pregnancy and early childhood wheezing.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1082766.535683 ◽

2007 ◽

Author(s):

Min Lu

Keyword(s):

Vitamin D ◽

Early Childhood ◽

Maternal Vitamin ◽

Vitamin D Intake

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Determinants of Postpartum Vitamin D Status in the Caucasian Mother-Offspring Pairs at a Latitude of 52°N: A Cross-Sectional Study

Annals of Nutrition and Metabolism ◽

10.1159/000437099 ◽

2015 ◽

Vol 67 (1) ◽

pp. 33-41 ◽

Cited By ~ 9

Author(s):

Justyna Czech-Kowalska ◽

Dariusz Gruszfeld ◽

Maciej Jaworski ◽

Dorota Bulsiewicz ◽

Julita Latka-Grot ◽

...

Keyword(s):

Vitamin D ◽

Cord Blood ◽

Sun Exposure ◽

Maternal Blood ◽

Cross Sectional Study ◽

Lower Percentage ◽

Season Of Birth ◽

Vitamin D Status ◽

Cross Sectional ◽

Vitamin D Intake

Background: High prevalence of vitamin D deficiency in pregnancy is recorded. Aim: To establish determinants of postpartum 25-hydroxyvitamin D (25(OH)D) levels on mothers and offspring. Methods: 25(OH)D level was measured in cord blood and maternal blood collected ≤3 weeks postpartum. Maternal socioeconomic status, vitamin D intake, sun exposure during pregnancy and maternal and neonatal fat mass (FM; dual X-ray absorptiometry) were assessed within 3 weeks postpartum. Results: A total of 174 mother-offspring pairs were enrolled. Maternal 25(OH)D <20 ng/ml was seen in 32 (51%) of summer and 82 (74%) of winter deliveries. Women with 25(OH)D <20 ng/ml had a 2-fold lower percentage of vitamin D intake of ≥800 IU/day than women with 25(OH)D ≥20 ng/ml (p = 0.02). FM (%) was comparable between groups (p > 0.05). Multiple regression analysis revealed the delivery season, prenatal vitamin D intake ≥800 IU/day and duration of supplementation to be the determinants of maternal 25(OH)D level (R2 = 0.26, p < 0.001). Maternal 25(OH)D level, season of birth and duration of maternal supplementation explained 83% of the variance in cord blood 25(OH)D level (R2 = 0.83, p < 0.001). Conclusions: The key determinants of higher maternal vitamin D status were the summer-autumn season of delivery and prenatal use of ≥800 IU/day of vitamin D. The cord blood 25(OH)D level was mainly determined by maternal 25(OH)D level and season of birth.

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Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children

Clinical & Experimental Allergy ◽

10.1111/j.1365-2222.2009.03234.x ◽

2009 ◽

Vol 39 (6) ◽

pp. 875-882 ◽

Cited By ~ 265

Author(s):

M. Erkkola ◽

M. Kaila ◽

B. I. Nwaru ◽

C. Kronberg-Kippilä ◽

S. Ahonen ◽

...

Keyword(s):

Vitamin D ◽

Allergic Rhinitis ◽

Maternal Vitamin ◽

Vitamin D Intake

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Prenatal maternal and cord blood vitamin D concentrations and negative affectivity in infancy

European Child & Adolescent Psychiatry ◽

10.1007/s00787-021-01894-4 ◽

2021 ◽

Author(s):

Sara Sammallahti ◽

Elisa Holmlund-Suila ◽

Runyu Zou ◽

Saara Valkama ◽

Jenni Rosendahl ◽

...

Keyword(s):

Vitamin D ◽

Cord Blood ◽

Negative Affectivity ◽

Maternal Serum ◽

Maternal Vitamin ◽

Hydroxyvitamin D ◽

Increased Risk ◽

Standard Deviations ◽

Temperamental Trait

AbstractHigher maternal vitamin D concentration during pregnancy is associated with better child mental health. Negative affectivity, an early-emerging temperamental trait, indicates an increased risk of psychopathology. We investigated if maternal early/mid-pregnancy 25-hydroxyvitamin D (25(OH)D) and neonatal cord blood 25(OH)D concentrations are associated with Negative affectivity in infancy. We studied term-born infants from the vitamin D Intervention in Infants study (VIDI, n = 777, follow-up rate 80%, Finland), and the Generation R Study (n = 1505, follow-up rate 40%, Netherlands). We measured maternal serum 25(OH)D at 6–27 weeks (VIDI) or 18–25 weeks (Generation R) of pregnancy, and cord blood 25(OH)D at birth (both cohorts). Caregivers rated infant Negative affectivity at 11.7 months (VIDI) or 6.5 months (Generation R) using the Revised Infant Behavior Questionnaire. Using linear regression, we tested associations between 25(OH)D and Negative affectivity adjusted for infant age, sex, season of 25(OH)D measurement, maternal age, education, smoking, and body-mass-index. Per 10 nmol/l increase in maternal early/mid-pregnancy 25(OH)D, infant Negative affectivity decreased by 0.02 standard deviations (95% confidence interval [CI] − 0.06, − 0.004) in VIDI, and 0.03 standard deviations (95% CI − 0.03, − 0.01) in Generation R. Cord blood 25(OH)D was associated with Negative affectivity in Generation R (− 0.03, 95% CI − 0.05, − 0.01), but not VIDI (0.00, 95% CI − 0.02, 0.02). Lower maternal 25(OH)D concentrations were consistently associated with higher infant Negative affectivity, while associations between cord blood 25(OH)D concentrations and Negative affectivity were less clear. Maternal vitamin D status during early- and mid-pregnancy may be linked with early-emerging differences in offspring behavior.

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