scholarly journals A high proportion of the Vδ1+ synovial fluid γδ T cells in juvenile rheumatoid arthritis patients express the very early activation marker CD69, but carry the high molecular weight isoform of the leucocyte common antigen (CD45RA)

2008 ◽  
Vol 91 (2) ◽  
pp. 202-206 ◽  
Author(s):  
J. KJELDSEN-KRAGH ◽  
A. J. QUAYLE ◽  
O. VINJE ◽  
J. B. NATVIG ◽  
Ø. FØRRE
Keyword(s):  
Rheumatoid Arthritis ◽  
Molecular Weight ◽  
T Cells ◽  
Synovial Fluid ◽  
High Molecular Weight ◽  
Juvenile Rheumatoid Arthritis ◽  
Γδ T Cells ◽  
Common Antigen ◽  
Activation Marker ◽  
Activation Marker Cd69

scholarly journals MRC OX-22, a monoclonal antibody that labels a new subset of T lymphocytes and reacts with the high molecular weight form of the leukocyte-common antigen.

1983 ◽  
Vol 158 (3) ◽  
pp. 795-810 ◽  
Author(s):  
G P Spickett ◽  
M R Brandon ◽  
D W Mason ◽  
A F Williams ◽  
G R Woollett
Keyword(s):  
Molecular Weight ◽  
Monoclonal Antibody ◽  
T Cells ◽  
B Cells ◽  
High Molecular Weight ◽  
Bone Marrow Cells ◽  
Common Antigen ◽  
Leukocyte Common Antigen ◽  
High Molecular Weight Form ◽  
Molecular Weight Form

A mouse monoclonal antibody (MRC OX-22) is described that labels rat T cells which mediate graft-versus-host reactions and those responsible for the suppression of antibody synthesis in hosts undergoing these reactions. In contrast, most of the T cells that provide help for B cells are MRC OX-22 negative. These results, taken together with those published previously, demonstrate that the rat contains at least three phenotypically and functionally distinct subsets of T cells. The MRC OX-22 antibody also labels all B cells, 50% of bone marrow cells, but only 2% of thymocytes. Of these latter cells about half are found at the edge of the medulla and the remainder are randomly distributed throughout the cortex and medulla. These findings lend support to the view that mature thymocytes leave the thymus at the cortico-medullary junction, and also suggest that both cortex and medulla may be sites where thymocytes mature. Biochemical studies showed that the MRC OX-22 antibody reacts with the high molecular weight form of the leukocyte-common antigen (L-CA). Comparison with data on human L-CA suggests that the molecular and antigenic heterogeneity of this set of glycoproteins has been conserved between rat and man.

scholarly journals High Expression of Fas Ligand by Synovial Fluid-Derived γδ T Cells in Lyme Arthritis

2003 ◽  
Vol 170 (5) ◽  
pp. 2702-2710 ◽  
Author(s):  
Karen Roessner ◽  
Julie Wolfe ◽  
Cuixia Shi ◽  
Leonard H. Sigal ◽  
Sally Huber ◽  
...  
Keyword(s):  
T Cells ◽  
Synovial Fluid ◽  
Fas Ligand ◽  
Γδ T Cells ◽  
Lyme Arthritis ◽  
High Expression
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