THE ROLE OF PROLACTIN IN THE RESTORATION OF OVARIAN FUNCTION DURING THE EARLY POST-PARTUM PERIOD IN THE HUMAN FEMALE.

Abstract Objective Epilepsy treatment during pregnancy is still challenging. The study is aimed at comparing the efficacy and safety of carbamazepine (CBZ), lamotrigine (LTG) and levetiracetam (LEV) monotherapies during pregnancy in women with focal (FE) or generalized (GE) epilepsy. Methods A multicentre retrospective study was conducted to evaluate seizures frequency and seizure freedom (SF) rate during 3 months before pregnancy, each trimester of gestation and post-partum period in women on monotherapy with CBZ, LTG and LEV. Results Fifty-seven pregnancies (45 FE, 12 GE) on monotherapy (29 CBZ, 11 LTG, 17 LEV) were included. A significant reduction of seizure frequency was found in the first trimester of pregnancy as compared with that one before pregnancy (p = 0.004), more evident in GE (p = 0.003) and in LEV group (p = 0.004). The SF rate significantly increased in the first trimester in comparison to that one before pregnancy and persisted in the post-partum period in the whole sample (p < 0.001) and in women on LEV (p = 0.004). Besides, 88.57% of SF women before pregnancy remained unchanged during gestation and the post-partum period. One major heart malformation in CBZ and no major malformations in LTG and LEV groups were found. Conclusions A better clinical outcome during pregnancy emerged since the first trimester in comparison to the before-pregnancy period, mostly evident in women with GE and LEV therapy, reinforcing the hypothesis of a protective role of pregnancy versus seizures. SF before pregnancy represents a significant predictive factor of good clinical outcome during gestation and the post-partum period. Compared to CBZ, LTG and LEV showed a better safety profile.

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Mood changes after delivery: role of the serotonin transporter gene

The British Journal of Psychiatry ◽

10.1192/bjp.bp.107.045427 ◽

2008 ◽

Vol 193 (5) ◽

pp. 383-388 ◽

Cited By ~ 62

Author(s):

J. Sanjuan ◽

R. Martin-Santos ◽

L. Garcia-Esteve ◽

J. M. Carot ◽

R. Guillamat ◽

...

Keyword(s):

Depressive Symptoms ◽

Major Depression ◽

Serotonin Transporter ◽

Post Partum ◽

Serotonin Transporter Gene ◽

High Expression ◽

Transporter Gene ◽

Mood Changes ◽

Post Partum Period

BackgroundPolymorphic variations in the serotonin transporter gene (5-HTT) moderate the depressogenic effects of tryptophan depletion. After childbirth there is a sharp reduction in brain tryptophan availability, thus polymorphic variations in5-HTTmay play a similar role in the post-partum period.AimsTo study the role of5-HTTpolymorphic variations in mood changes after delivery.MethodOne thousand, eight hundred and four depression-free Spanish women were studied post-partum. We evaluated depressive symptoms at 2–3 days, 8 weeks and 32 weeks post-partum. We used diagnostic interview to confirm major depression for all probable cases. Based on two polymorphisms of5-HTT(5-HTTLPR and STin2 VNTR), three genotype combinations were created to reflect different levels of5-HTTexpression.ResultsOne hundred and seventy-three women (12.7%) experienced major depression during the 32-week post-partum period. Depressive symptoms were associated with the high-expression5-HTTgenotypes in a dose–response fashion at 8 weeks post-partum, but not at 32 weeks.ConclusionsHigh-expression5-HTTgenotypes may render women more vulnerable to depressive symptoms after childbirth.

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Influence of diet composition, dry-matter intake, milk production and energy balance on time of post-partum ovulation and fertility in dairy cows

Animal Science ◽

10.1017/s0003356100020778 ◽

1992 ◽

Vol 54 (3) ◽

pp. 323-331 ◽

Cited By ~ 105

Author(s):

M. C. Lucy ◽

C. R. Staples ◽

W. W. Thatcher ◽

P. S. Erickson ◽

R. M. Cleale ◽

...

Keyword(s):

Energy Balance ◽

Dry Matter ◽

Ovarian Function ◽

Post Partum ◽

Food Additives ◽

Dry Matter Intake ◽

Holstein Friesian ◽

Days Open ◽

Post Partum Period ◽

Friesian Cows

AbstractLactating Holstein-Friesian cows from two calving groups (no. = 90) were studied during the early post-partum period to determine the effect of dry-matter intake (DM1), 40 g/kg fat-corrected milk (FCM) production, energy balance (EB), parity, and food additives (calcium salts of long-chain fatty acids [CaLCFA] and niacin) on the recrudescence of ovarian function and establishment of pregnancy. Cows that ovulated early during the post-partum period (15 to 21 days after calving) consumed more food and tended to produce more FCM compared with cows ovulating later (22 to 42 days or after 42 days). Primiparous cows had lower EB and tended to have longer intervals to first ovulation compared with multiparous cows but the average interval to pregnancy was similar for primiparous and multiparous cows. Feeding CaLCFA tended to extend the interval to first service and decreased pregnancy rate. Production characteristics (including DMI and FCM production) seem to determine interval from calving to first ovulation as well as interval from calving to pregnancy (days open). Fertility was affected negatively by feeding CaLCFA.

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The effects of plane of nutrition, live weight, temporary weaning and breed on the occurrence of oestrus in beef cows during the post-partum period

Animal Science ◽

10.1017/s0003356100011995 ◽

1978 ◽

Vol 26 (1) ◽

pp. 47-54 ◽

Cited By ~ 24

Author(s):

D. H. Holness ◽

J. D. H. Hopley ◽

D. H. Hale

Keyword(s):

Nutrient Intake ◽

Ovarian Function ◽

Post Partum ◽

Live Weight ◽

Beef Cows ◽

Apparent Effect ◽

Short Term ◽

The Mean ◽

Post Partum Period ◽

Mean Time

ABSTRACTThe occurrence of oestrus and ovarian function during the post-partum period was examined in 160 lactating beef cows of the Africander and Mashona breeds. Cows were fed either to gain 12 to 14% (High) or to lose 12 to 14% (Low) of their autumn peak live weight (early pregnancy) by mid-breeding season. Half the cows in each group were subjected to an increase (Low-High) or decrease (High-Low) in nutrient intake for a 25-day period starting at 25 days partum. Nursing was interrupted for an 8-day period in half of the cows at 50 days post partum by the application of nose plates to their calves.Oestrus occurred significantly earlier in the high than the low plane cows (66 v. 75 days post partum respectively, P< 0·05), but short-term fluctuations in nutrient supply had no apparent effect on the incidence of oestrus. Temporary weaning significantly reduced the mean time from calving to first oestrus in the high-plane (P< 0·01) but not in the low-plane cows, and in Mashona (P<0·05) but not in Africander cows. There was a lower incidence of ‘silent’ oestrus and the mean occurrence of oestrus was significantly earlier (P< 0·001) in the Mashona when compared with the Africander cows.

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Regulatory role of resistin on ovarian function

Reproduction Abstracts ◽

10.1530/repabs.1.p139 ◽

2014 ◽

Author(s):

Agnieszka Rak-Mardyla ◽

Anna Wrobel ◽

Eliza Drwal ◽

Ewa Gregoraszczuk

Keyword(s):

Ovarian Function ◽

Regulatory Role

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Low back pain in pregnancy and post-partum period. Principles for medical rehabilitation

Ginecologia ro ◽

10.26416/gine.19.1.2018.1512 ◽

2018 ◽

Vol 1 (19) ◽

pp. 22

Author(s):

Iulia Filipescu ◽

Mihai Berteanu ◽

George Alexandru Filipescu ◽

Radu Vlădăreanu

Keyword(s):

Low Back Pain ◽

Back Pain ◽

Post Partum ◽

Medical Rehabilitation ◽

Low Back ◽

Post Partum Period ◽

In Pregnancy

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Study of Possible Relation between Fasting Plasma Glucagon, Gestational Diabetes and Development of Type 2 DM

Current Diabetes Reviews ◽

10.2174/1573399815666190405171907 ◽

2020 ◽

Vol 16 (2) ◽

pp. 148-155 ◽

Cited By ~ 1

Author(s):

Ashraf Okba ◽

Salwa Seddik Hosny ◽

Alyaa Elsherbeny ◽

Manal Mohsin Kamal

Keyword(s):

Gestational Diabetes ◽

Pregnant Women ◽

Post Partum ◽

Plasma Glucagon ◽

Type 2 Dm ◽

Fasting Plasma ◽

Before And After ◽

Two Phases

Background and Aims: Women who develop GDM (gestational diabetes mellitus) have a relative insulin secretion deficiency, the severity of which may be predictive for later development of diabetes. This study aimed to investigate the role of fasting plasma glucagon in the prediction of later development of diabetes in pregnant women with GDM. Materials and Methods: The study was conducted on 150 pregnant women with GDM after giving informed oral and written consents and being approved by the research ethical committee according to the declaration of Helsinki. The study was conducted in two phases, first phase during pregnancy and the second one was 6 months post-partum, as we measured fasting plasma glucagon before and after delivery together with fasting and 2 hour post-prandial plasma sugar. Results: Our findings suggested that glucagon levels significantly increased after delivery in the majority 14/25 (56%) of GDM women who developed type 2 DM within 6 months after delivery compared to 6/20 (30%) patients with impaired fasting plasma glucose (IFG) and only 22/105 (20%) non DM women, as the median glucagon levels were 80,76, 55, respectively. Also, there was a high statistical difference between fasting plasma glucagon post-delivery among diabetic and non-diabetic women (p ≤ 0.001). These results indicated the useful role of assessing fasting plasma glucagon before and after delivery in patients with GDM to predict the possibility of type 2 DM. Conclusion: There is a relatively high glucagon level in GDM patients, which is a significant pathogenic factor in the incidence of subsequent diabetes in women with a history of GDM. This could be important in the design of follow-up programs for women with previous GDM.

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Using Anti-Cancer Agents during the Post-Partum Period: Not that Simple

Onkologie ◽

10.1159/000318794 ◽

2010 ◽

Vol 33 (8-9) ◽

pp. 419-419 ◽

Cited By ~ 3

Author(s):

Olivier Mir ◽

Paul Berveiller ◽

Raphaël Serreau

Keyword(s):

Post Partum ◽

Anti Cancer ◽

Post Partum Period

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