scholarly journals Antibody repertoire development in fetal and neonatal piglets. XI. The thymic B-cell repertoire develops independently from that in blood and mesenteric lymph nodes

Immunology ◽  
2005 ◽  
Vol 114 (2) ◽  
pp. 171-183 ◽  
Author(s):  
Jeremy McAleer ◽  
Patrick Weber ◽  
Jishan Sun ◽  
John E. Butler
Keyword(s):  
Lymph Nodes ◽  
B Cell ◽  
Antibody Repertoire ◽  
Mesenteric Lymph Nodes ◽  
Cell Repertoire ◽  
Neonatal Piglets ◽  
Mesenteric Lymph ◽  
B Cell Repertoire ◽  
Repertoire Development

scholarly journals Neonatal Exposure to Commensal-Bacteria-Derived Antigens Directs Polysaccharide-Specific B-1 B Cell Repertoire Development

Immunity ◽  
2020 ◽  
Vol 53 (1) ◽  
pp. 172-186.e6 ◽  
Author(s):  
J. Stewart New ◽  
Brian L.P. Dizon ◽  
Christopher F. Fucile ◽  
Alexander F. Rosenberg ◽  
John F. Kearney ◽  
...  
Keyword(s):  
B Cell ◽  
Commensal Bacteria ◽  
Neonatal Exposure ◽  
Cell Repertoire ◽  
B Cell Repertoire ◽  
Repertoire Development

scholarly journals Positive selection of the peripheral B cell repertoire in gut-associated lymphoid tissues

2004 ◽  
Vol 201 (1) ◽  
pp. 55-62 ◽  
Author(s):  
Ki-Jong Rhee ◽  
Paul J. Jasper ◽  
Periannan Sethupathi ◽  
Malathy Shanmugam ◽  
Dennis Lanning ◽  
...  
Keyword(s):  
B Cells ◽  
B Cell ◽  
Intestinal Microflora ◽  
Molecular Mechanisms ◽  
Amino Acid Sequences ◽  
Lymphoid Tissues ◽  
Antibody Repertoire ◽  
Cell Repertoire ◽  
B Cell Repertoire ◽  
The Relationship

Gut-associated lymphoid tissues (GALTs) interact with intestinal microflora to drive GALT development and diversify the primary antibody repertoire; however, the molecular mechanisms that link these events remain elusive. Alicia rabbits provide an excellent model to investigate the relationship between GALT, intestinal microflora, and modulation of the antibody repertoire. Most B cells in neonatal Alicia rabbits express VHn allotype immunoglobulin (Ig)M. Within weeks, the number of VHn B cells decreases, whereas VHa allotype B cells increase in number and become predominant. We hypothesized that the repertoire shift from VHn to VHa B cells results from interactions between GALT and intestinal microflora. To test this hypothesis, we surgically removed organized GALT from newborn Alicia pups and ligated the appendix to sequester it from intestinal microflora. Flow cytometry and nucleotide sequence analyses revealed that the VHn to VHa repertoire shift did not occur, demonstrating the requirement for interactions between GALT and intestinal microflora in the selective expansion of VHa B cells. By comparing amino acid sequences of VHn and VHa Ig, we identified a putative VH ligand binding site for a bacterial or endogenous B cell superantigen. We propose that interaction of such a superantigen with VHa B cells results in their selective expansion.

B-Cell Leukemia in a Sheep

2003 ◽  
Vol 40 (1) ◽  
pp. 117-119 ◽  
Author(s):  
B. A. Valentine ◽  
S. P. Mcdonough
Keyword(s):  
Lymph Nodes ◽  
Respiratory Distress ◽  
B Cell ◽  
Mononuclear Cells ◽  
Final Diagnosis ◽  
Cell Leukemia ◽  
Mesenteric Lymph Nodes ◽  
Tissue Sections ◽  
Mesenteric Lymph ◽  
B Cell Leukemia

Necropsy examination was performed on an 8.5-year-old Finnish ewe euthanatized because of progressive respiratory distress, cachexia, and weakness. Significant postmortem findings included a diffusely enlarged, dark-red friable liver, mild splenomegaly, and mild mesenteric lymphadenopathy. Examination of multiple tissue sections revealed intravascular atypical mononuclear cells in all tissues examined, with a leukemic pattern of infiltration of mesenteric lymph nodes, liver, lung, and spleen. Neoplastic cells were positive for CD79a and negative for CD-3, BLA.36, and CD68 leukocytic markers. The final diagnosis was B-cell leukemia.

scholarly journals Antibody Repertoire Development in Fetal and Neonatal Piglets. VI. B Cell Lymphogenesis Occurs at Multiple Sites with Differences in the Frequency of In-frame Rearrangements

2003 ◽  
Vol 170 (4) ◽  
pp. 1781-1788 ◽  
Author(s):  
Marek Šinkora ◽  
Jishan Sun ◽  
Jana Šinkorová ◽  
Ronald K. Christenson ◽  
Steven P. Ford ◽  
...  
Keyword(s):  
B Cell ◽  
Antibody Repertoire ◽  
Neonatal Piglets ◽  
Repertoire Development

Effects of Inhaled Hexachlorobenzene Aerosols on Rat Pulmonary Host Defenses

1989 ◽  
Vol 5 (3) ◽  
pp. 451-461 ◽  
Author(s):  
Robert L. Sherwood ◽  
Peter T. Thomas ◽  
William J. O'shea ◽  
Jeannie N. Bradof ◽  
Helen V. Ratajczak ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
B Cell ◽  
Bactericidal Activity ◽  
Peritoneal Macrophages ◽  
Sprague Dawley ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph ◽  
Sprague Dawley Rats ◽  
Cell Mitogen

Pulmonary bactericidal activity, macrophage phagocytic activity, alveolar macrophage (AM) enzyme activity, and T- and B-cell mitogenesis of lymphocytes from lung associated lymph nodes (LALN) or mesenteric lymph nodes (MESLN) were assessed in Sprague-Dawley rats exposed 4 hr/d, 4 days/wk for 1, 4, or 16 days to hexachlorobenzene (HCB) aerosols. Pulmonary bactericidal activity was depressed after 1 or 4 but not 16 exposures to 35 mg/m3 of HCB. AM phagocytosis of 51Cr-RBC in vitro was increased after 4 but not 1 or 16 exposures to HCB, and no effect was observed in peritoneal macrophages. HCB significantly enhanced mitogenesis in MESLN to the B-cell mitogen Salmonella typhimurium lipopolysaccharide (STM) after 4 exposures; LALN STM mitogenesis and LALN and MESLN mitogenesis to phytohemagglutinin (PHA) were not affected. After 16 exposures, however, the PHA responses in LALN and MESLN were significantly increased and decreased, respectively.

B-cell activation in the mesenteric lymph nodes of resistant BALB/c mice infected with the murine nematode parasite Trichuris muris

1999 ◽  
Vol 85 (3) ◽  
pp. 194-199 ◽  
Author(s):  
Koichi Koyama ◽  
Hidekazu Tamauchi ◽  
Masahiro Tomita ◽  
Takashi Kitajima ◽  
Yoichi Ito
Keyword(s):  
Lymph Nodes ◽  
B Cell ◽  
Cell Activation ◽  
Nematode Parasite ◽  
B Cell Activation ◽  
Mesenteric Lymph Nodes ◽  
Trichuris Muris ◽  
Mesenteric Lymph

scholarly journals Antibody repertoire development in fetal and neonatal piglets. XXII. λ rearrangement precedes κ rearrangement during B-cell lymphogenesis in swine

Immunology ◽  
2012 ◽  
Vol 137 (2) ◽  
pp. 149-159 ◽  
Author(s):  
Xiuzhu Sun ◽  
Nancy Wertz ◽  
Kelly Lager ◽  
Marek Sinkora ◽  
Katerina Stepanova ◽  
...  
Keyword(s):  
B Cell ◽  
Antibody Repertoire ◽  
Neonatal Piglets ◽  
Repertoire Development
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