scholarly journals Tumor escape mechanisms: potential role of soluble HLA antigens and NK cells activating ligands

2008 ◽  
Vol 72 (4) ◽  
pp. 321-334 ◽  
Author(s):  
M. Campoli ◽  
S. Ferrone
Keyword(s):  
Nk Cells ◽  
Potential Role ◽  
Hla Antigens ◽  
Tumor Escape ◽  
Soluble Hla

scholarly journals NK cells and CD38: Implication for (Immuno)Therapy in Plasma Cell Dyscrasias

Cells ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 768 ◽  
Author(s):  
Renato Zambello ◽  
Gregorio Barilà ◽  
Sabrina Manni ◽  
Francesco Piazza ◽  
Gianpietro Semenzato
Keyword(s):  
Multiple Myeloma ◽  
Monoclonal Antibodies ◽  
Immune System ◽  
Nk Cells ◽  
Plasma Cell ◽  
Potential Role ◽  
Myeloma Cell ◽  
Initial Reduction ◽  
Plasma Cell Dyscrasias

Immunotherapy represents a promising new avenue for the treatment of multiple myeloma (MM) patients, particularly with the availability of Monoclonal Antibodies (mAbs) as anti-CD38 Daratumumab and Isatuximab and anti-SLAM-F7 Elotuzumab. Although a clear NK activation has been demonstrated for Elotuzumab, the effect of anti-CD38 mAbs on NK system is controversial. As a matter of fact, an initial reduction of NK cells number characterizes Daratumumab therapy, limiting the potential role of this subset on myeloma immunotherapy. In this paper we discuss the role of NK cells along with anti-CD38 therapy and their implication in plasma cell dyscrasias, showing that mechanisms triggered by anti-CD38 mAbs ultimately lead to the activation of the immune system against myeloma cell growth.

Inhibition of Alloreactive Cytotoxic T Cell Activity by HIV-Positive Sera: Potential Role of Circulating Soluble HLA Class I Molecules

1994 ◽  
Vol 10 (9) ◽  
pp. 1061-1064 ◽  
Author(s):  
FRANCESCO PUPPO ◽  
SABRINA BRENCI ◽  
ELEONORA MONTINARO ◽  
LORELLA LANZA ◽  
PAOLA CONTINI ◽  
...  
Keyword(s):  
T Cell ◽  
Potential Role ◽  
Cell Activity ◽  
Hla Class I ◽  
Class I ◽  
Cytotoxic T Cell ◽  
Hiv Positive ◽  
Hla Class I Molecules ◽  
Soluble Hla

scholarly journals PD/1-PD-Ls Checkpoint: Insight on the Potential Role of NK Cells

2019 ◽  
Vol 10 ◽  
Author(s):  
Silvia Pesce ◽  
Marco Greppi ◽  
Francesco Grossi ◽  
Genny Del Zotto ◽  
Lorenzo Moretta ◽  
...  
Keyword(s):  
Nk Cells ◽  
Potential Role

scholarly journals The Role of Natural Killer Cells in Sepsis

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Laurent Chiche ◽  
Jean-Marie Forel ◽  
Guillemette Thomas ◽  
Catherine Farnarier ◽  
Fréderic Vely ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Nk Cells ◽  
Natural Killer ◽  
Immune Cells ◽  
Potential Role ◽  
Nk Cell ◽  
Early Stage ◽  
Sepsis And Septic Shock

Severe sepsis and septic shock are still deadly conditions urging to develop novel therapies. A better understanding of the complex modifications of the immune system of septic patients is needed for the development of innovative immunointerventions. Natural killer (NK) cells are characterized as CD3−NKp46+CD56+cells that can be cytotoxic and/or produce high amounts of cytokines such as IFN-γ. NK cells are also engaged in crosstalks with other immune cells, such as dendritic cells, macrophages, and neutrophils. During the early stage of septic shock, NK cells may play a key role in the promotion of the systemic inflammation, as suggested in mice models. Alternatively, at a later stage, NK cells-acquired dysfunction could favor nosocomial infections and mortality. Standardized biological tools defining patients' NK cell status during the different stages of sepsis are mandatory to guide potential immuno-interventions. Herein, we review the potential role of NK cells during severe sepsis and septic shock.

Potential Role of NK Cells in the Induction of Immune Responses: Implications for NK Cell–Based Immunotherapy for Cancers and Viral Infections

2008 ◽  
Vol 27 (3) ◽  
pp. 93-110 ◽  
Author(s):  
Hiroshi Terunuma ◽  
Xuewen Deng ◽  
Zahidunnabi Dewan ◽  
Shigeyoshi Fujimoto ◽  
Naoki Yamamoto
Keyword(s):  
Immune Responses ◽  
Nk Cells ◽  
Potential Role ◽  
Viral Infections ◽  
Nk Cell

scholarly journals The Role of Progesterone in Feto-Maternal Immunological Cross Talk

2018 ◽  
Vol 27 (4) ◽  
pp. 301-307 ◽  
Author(s):  
Julia Szekeres-Bartho
Keyword(s):  
T Cells ◽  
Immune System ◽  
Nk Cells ◽  
Hla Antigens ◽  
Γδ T Cells ◽  
Normal Pregnancy ◽  
Maternal Immune System ◽  
Immunological Recognition ◽  
Immunological Relationship

This review aims to provide a brief historical overview of the feto-maternal immunological relationship, which profoundly influences the outcome of pregnancy. The initial question posed in the 1950s by Medawar [Symp Soc Exp Biol. 1953; 7: 320–338] was based on the assumption that the maternal immune system recognizes the fetus as an allograft. Indeed, based on the association between HLA-matching and spontaneous miscarriage, it became obvious that immunological recognition of pregnancy is required for a successful gestation. The restricted expression of polymorphic HLA antigens on the trophoblast, together with the presence of nonpolymorphic MHC products, excludes recognition by both T and NK cells of trophoblast-presented antigens; however, γδ T cells, which constitute the majority of decidual T cells, are likely candidates. Indeed, a high number of activated, progesterone receptor-expressing γδ T cells are present in the peripheral blood of healthy pregnant women and, in the presence of progesterone, these cells secrete an immunomodulatory protein called progesterone-induced blocking factor (PIBF). As early as in the peri-implantation period, the embryo communicates with the maternal immune system via PIBF containing extracellular vesicles. PIBF contributes to the dominance of Th2-type reactivity which characterizes normal pregnancy by inducing increased production of Th2 cytokines. The high expression of this molecule in the decidua might be one of the reasons for the low cytotoxic activity of decidual NK cells.

Association of HLA-G Haplotype Risk Model with Treatment Free Survival In Chronic Lymphocytic Leukemia Patients

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 2418-2418
Author(s):  
Johanna Kapp ◽  
Crista Ochsenfarth ◽  
Magdalena Switala ◽  
Ulrich Frey ◽  
Ludger Sellmann ◽  
...  
Keyword(s):  
Risk Model ◽  
Risk Allele ◽  
Conflicts Of Interest ◽  
Hla Antigens ◽  
Human Leukocyte ◽  
Lymphocytic Leukemia ◽  
Rank Test ◽  
Tumor Escape ◽  
Risk Alleles

Abstract Abstract 2418 Introduction: The human leukocyte antigen G (HLA-G) molecule exhibits limited tissue distribution and exerts multiple immunoregulatory functions. Since the net result of these effects is immunosuppression, HLA-G expression in tumor cells may favor their escape from antitumor immune responses, thus allowing tumor progression. The HLA-G protein polymorphism is extremely restricted in comparison to the classical HLA antigens. However, specific HLA-G polymorphisms in exons 3, 4, 5, 7 and parts of the 3`UTR encode for different haplotypes. Demonstrating the extensive and proven prognostic role of HLA-G in various diseases and especially in B-CLL we investigated the role of the HLA-G haplotypes in B-CLL. Methods: Genotyping was performed on the basis of examining exons 3, 4, 5, 7 and parts of the 3`UTR by pyrosequencing in 190 patients with B-CLL. In total, we found 17 different haplotypes in the cohort. Results: The haplotype distributions between 190 B-CLL patients and 190 healthy controls were not different, arguing that the haplotypes of HLA-G do not increase the susceptibility for B-CLL. However, combining four different haplotypes (*01:06, *01:12; *01:12 variant and *01:13N) we evaluated a risk score (0=no risk allele; 1=one risk allele; 2=two risk alleles) for TFS. 77 patients showed no risk allele, 90 patients one risk allele and 23 patients two risk alleles. The TFS for those patients with two risk alleles were significantly shorter (median TFS 33 months) than for those with one risk allele (median TFS 49 months) and those with no risk alleles (median TFS 88 months)(log rank test: p=0.03). In multivariate analysis we could show that the stage according to Binet (HR 1.7, 95% CI 1.2–2.6, p=0.005), CD38 status (HR 1.8, 95% CI 1.0–3.2, p=0.04) and the haplotype risk model (HR 1.7, 95% CI 1.1–2.6, p=0.011) were independent predictors for first therapy. Conclusion: Our study is the first study demonstrating that the combination of different alleles of the HLA-G gene is associated with the risk of first therapy in B-CLL patients. This fact emphasizes the extensive role of this gene by the tumor escape mechanism and could be responsible for progress in other cancers. Disclosures: No relevant conflicts of interest to declare.

Potential Role of NK Cells in Progression of Intraductal Papillary Mucinous Neoplasms (IPMN)

2016 ◽  
Vol 223 (4) ◽  
pp. e142-e143
Author(s):  
Lei Cai ◽  
Theodoros Michelakos ◽  
Carlos Fernandez-del Castillo ◽  
Andrew L. Warshaw ◽  
Keith D. Lillemoe ◽  
...  
Keyword(s):  
Nk Cells ◽  
Potential Role ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Mucinous Neoplasms

scholarly journals Possible involvement of the T4 molecule in T cell recognition of class II HLA antigens. Evidence from studies of CTL-target cell binding.

1984 ◽  
Vol 159 (3) ◽  
pp. 783-797 ◽  
Author(s):  
W E Biddison ◽  
P E Rao ◽  
M A Talle ◽  
G Goldstein ◽  
S Shaw
Keyword(s):  
Target Cell ◽  
Potential Role ◽  
Cytotoxic T Lymphocyte ◽  
Hla Antigens ◽  
Class Ii ◽  
Target Cells ◽  
Cell Recognition ◽  
Cell Binding ◽  
T Cell Recognition

The present study examines the potential role of the T4 molecule in functional cell-cell interactions between target cells and human cytotoxic T lymphocyte (CTL) clones that are specific for HLA class II alloantigens encoded by the SB locus. There were marked differences (greater than 30-fold) between the seven SB-specific clones studied with respect to their susceptibility to inhibition by anti-T4 as well as anti-T3 antibodies. We wished to test the hypothesis that such variation among the clones would be due to differences in clonal "affinity" for antigen. To quantitate differences among the CTL clones in the tightness with which they bind target cells, the clones were analyzed using a previously published assay of susceptibility of CTL-target cell conjugates to dissociation in the presence of unlabeled targets. The results revealed that the clones that were most susceptible to inhibition by anti-T4 and anti-T3 were the weakest target cell binders, and vice versa. Anti-T4 antibody could partially induce dissociation of functional CTL-target cell conjugates in the absence of any added cold targets. For the "highest affinity" clone such anti-T4 antibody-induced dissociation could be observed at 4 degrees C but not 23 degrees C. These results indicate that the T4 molecule is functionally involved in target cell binding by CTL, and raise the possibility that although it is easiest to demonstrate the function of the T4 molecule in "low affinity" clones, that function may also be operative in the "high affinity" clones.

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