Should diagnostic laparoscopy be performed initially or not, during infertility management of primary and secondary infertile women? A cross-sectional study

The relationship between serum dehydroepiandrosterone sulphate (DHEA-S) and anti-Mullerian hormone (AMH) levels has not been fully established. Therefore, we performed a large-scale cross-sectional study to investigate the association between serum DHEA-S and AMH levels. The study included a total of 2155 infertile women aged 20 to 46 years who were divided into four quartile groups (Q1 to Q4) based on serum DHEA-S levels. We found that there was a weak positive association between serum DHEA-S and AMH levels in infertile women (r = 0.190, p < 0.001). After adjusting for potential confounders, serum DHEA-S levels positively correlated with serum AMH levels in infertile women (β = 0.103, p < 0.001). Infertile women in the highest DHEA-S quartile category (Q4) showed significantly higher serum AMH levels (p < 0.001) compared with women in the lowest DHEA-S quartile category (Q1). The serum AMH levels significantly increased across increasing DHEA-S quartile categories in infertile women (p = 0.014) using generalized linear models after adjustment for potential confounders. Our data show that serum DHEA-S levels are positively associated with serum AMH levels.

Download Full-text

RELATIONSHIP BETWEEN DEPRESSION, ANXIETY AND STRESS WITH QUALITY OF LIFE OF INFERTILE COUPLES

10.36106/ijsr/9628314 ◽

2020 ◽

pp. 1-3

Author(s):

Jisha M. ◽

Dr Assuma Beevi.T. M.

Keyword(s):

Quality Of Life ◽

Cross Sectional Study ◽

Social Effects ◽

Anxiety And Depression ◽

Sectional Study ◽

Cross Sectional ◽

Infertile Women ◽

Stress Scale ◽

Infertile Couples

Introduction: Psychological and social effects of infertility may cause decline in the quality of life of infertile couples. A cross sectional study was conducted among 100 infertile couples, to find out the association between level of stress, anxiety and depression with their quality of life. Materials and methods: Data was collected using demographic and fertility information questionnaire, depression anxiety and stress scale (DASS-42) and fertility quality of life (fertiQol-malayalam). Results: Infertile couples experiences higher levels of depression, anxiety and stress and it is more among women,(depression-(15.36 +_ 9.23), stress(16.3+-7.52) anxiety (9.36+_6.33) than men (depression(12.52+_10.30 )(P=0.030), stress(12.84+_ 7.94 )(P=0-002 ) anxiety(7.50+_5-55). Levels of depression, anxiety and stress have significant negative relation with their quality of life. Infertile women has significantly lower quality of life (P= 0.002) than men. Conclusion: Interventions, to reduce depression, anxiety and stress among infertile couples may be helpful to improve their quality of life.

Download Full-text

AMH and AMHR2 Polymorphisms and AMH Serum Level Can Predict Assisted Reproduction Outcomes: A Cross-Sectional Study

Cellular Physiology and Biochemistry ◽

10.1159/000373961 ◽

2015 ◽

Vol 35 (4) ◽

pp. 1401-1412 ◽

Cited By ~ 17

Author(s):

Carla Peluso ◽

Fernando L.A. Fonseca ◽

Guilherme G. Gastaldo ◽

Denise M. Christofolini ◽

Emerson Barchi Cordts ◽

...

Keyword(s):

Serum Level ◽

Assisted Reproduction ◽

Controlled Ovarian Hyperstimulation ◽

Cross Sectional Study ◽

Human Reproduction ◽

Ovarian Hyperstimulation ◽

Sectional Study ◽

Cross Sectional ◽

Infertile Women ◽

Assisted Reproductive Treatment

Background: In human assisted reproduction, the ovarian response to exogenous recombinant Follicle-stimulating Hormone (FSH) therapy is variable and difficult to predict. The standard protocol of ovarian hyperstimulation can result in satisfactory response; however, an unsatisfactory response necessitates FSH dose adjustment or results in ovarian hyperstimulation syndrome (OHSS). Polymorphisms in AMH and AMHR2 genes appear to affect hormone biological activities, thus affecting follicle recruitment and development, leading to infertility. We aimed to evaluate AMH and AMHR2 polymorphisms in infertile women, and correlate those findings with AMH, FSH and estradiol serum level response to controlled ovarian hyperstimulation (COH), as well as assisted reproduction outcomes. Methods: A cross-sectional study comprising 186 infertile women that underwent one cycle of high complexity assisted reproductive treatment. Blood samples were collected and a TaqMan assay was used for AMH G146T/rs10407022 and AMHR2 A-482G/rs2002555, A10G/rs11170555, C1749G/rs2071558 and G4952A/rs3741664 genotyping, and FSH, estradiol and AMH levels were measured. The findings were correlated to human reproduction outcomes. Results: AMH rs10407022 and AMHR2 rs2002555 polymorphisms were not associated with hormonal measurements, whereas AMHR2 rs11170555 and rs3741664 were positively associated with AMH, estradiol and FSH levels. The genotype distribution of AMH and AMHR2 genes according to Controlled Ovarian Hyperstimulation did not show a positive association. However, an association with AFC, degree of oocyte maturation (allele G of AMHR2 rs2071558) the number of embryos produced (alleles T and G of AMH rs10407022 and AMHR2 rs2002555, respectively) and frozen embryo (allele G of AMHR2 rs11170555) were found to be statistically associated. Considering COH, serum AMH and AFC were a positive predictor to OHSS. Regarding serum AMH and assisted reproduction outcomes, a positive correlation with all variables studied was found. Comparing AFC and AMH as predictors of human reproduction outcomes, the AFC was less effective than serum AMH. Considering pregnancy rates, no marker was positively associated. Conclusion: AMHR2 polymorphisms were associated with estradiol, AMH and FSH measurements, as well as number and quality of embryos, while AMH polymorphisms was associated with number of embryos produced. Serum AMH was correlated with nearly all variables analyzed in assisted reproductive treatment, demonstrating that it represents a better biomarker of OHSS and human reproduction outcomes compared to AMH and AMHR2 polymorphisms.

Download Full-text

Validity of The Fertility Quality of Life (FertiQol) Questionnaire in Indonesian Infertile Women

KnE Medicine ◽

10.18502/kme.v1i1.642 ◽

2017 ◽

Vol 1 (1) ◽

pp. 202

Author(s):

Muhammad D. Priangga ◽

Gita Pratama ◽

Mila Maidarti ◽

Achmad K. Harzif ◽

Budi Wiweko

Keyword(s):

Quality Of Life ◽

Statistical Analysis ◽

Cross Sectional Study ◽

Sectional Study ◽

Validity And Reliability ◽

Cross Sectional ◽

Infertile Women ◽

The Mean ◽

Preliminary Study

IntroductionInfertility in Indonesia has an estimated prevalence as high as 22.3%, with the nature of the problem and its treatment could be devastating, it could affect quality of life and vice versa influence successful of the treatment. The Fertility Quality of Life (FertiQol) Questionnaire was specifically designed for infertility couples and has been demonstrated to have good properties. Studies in several countries has showed consistency in validity and reliability of the questionnaire. Precedently there has been no published study about Fertiqol in Indonesia, this preliminary study is to measure validity and reliability of FertiQol questionnaire among Indonesian infertility women. Material & MethodsThis is a cross-sectional study, a written Fertiqol Questionnaire Indonesian version (www.Fertiqol.org) were distribute to Infertility clinic in Cipto Mangunkusumo General Hospital, total of 129 women completed the questionnaire. Statistical analysis used SPSS version 23.0. The questionnaire were tested for validity with Pearson’s correlation with two tailed and Cronbach α coefficient for reliability. ResultsFertiQol were completed by 129 women with infertility problem. The mean of total FertiQol score was 70.49±11.44, score for emotional, mind/body, relational, environment and tolerability was respectively 63.79±18.86; 66.05±18.22; 75.19.±15.11; 68.99±18.63; 75.64±16.55; 66.23±19.17. Reliability of Fertiqol was high (Cronbach a > 0.70) with every item of questionnaires was valid ( r> 0.1729). ConclusionThis study showed that FertiQol Indonesian version are valid and reliable in measured quality of life among infertility women in Indonesia.

Download Full-text

Investigating Hysteroscopy Implementation in Infertile Women Candidate With a Normal Uterine Cavity for Laparoscopy in Hysterosalpingography

International Journal of Women s Health and Reproduction Sciences ◽

10.15296/ijwhr.2019.13 ◽

2018 ◽

Vol 7 (1) ◽

pp. 79-84

Author(s):

Maliheh Amirian ◽

Anis Darvish Mohammadabad ◽

Negar Morovatdar ◽

Leili Hafizi

Keyword(s):

Diagnostic Laparoscopy ◽

False Negative ◽

Uterine Cavity ◽

Cross Sectional Study ◽

P Value ◽

Cross Sectional ◽

Endometrial Polyps ◽

Infertile Women ◽

Submucous Myoma ◽

Age Range

Objectives: Endometrial pathologies inside the cavity can occur simultaneously with gestational unpleasant consequences but are not always capable of being diagnosed by the hysterosalpingography (HSG). This study aimed to examine the value of performing diagnostic hysteroscopy beside diagnostic laparoscopy among infertile women with normal uterine cavities in HSG. Materials and Methods: A total of 103 infertile women with normal uterine cavities in the HSG and within the age range of 18-40 who referred to Imam Reza hospital for laparoscopy during 2016-2017 were included in this cross-sectional study. Hysteroscopy was performed simultaneously with diagnostic laparoscopy. Then, the existence of uterine pathologies like endometrial polyps, submucous myoma, and uterine endometrial adhesions and their relationship with the patient’s age, infertility type and duration, and cycle time were evaluated. A P value less than 0.05 was considered statistically significant. Results: Overall, 64 patients (63.1 %) had a normal uterine cavity in the hysteroscopy while 39 of them had an abnormal uterine cavity, the HSG false negative cases of whom were reported 37.9%. The pathologies found in the hysteroscopy were endometrial polyp (16 cases), submucous myoma (1 case), uterine septum (6 cases), asherman syndrome (7 cases), bicornuate uterus (4 cases), polyp + asherman (3 cases), polyp + submucous myoma (1 case), and septum + submucous myoma (1 case). Patients’ age, type of infertility, and menstruation time during performing hysteroscopy made no particular difference in diagnosing pathologies of the uterine cavity in the hysteroscopy. Conclusions: Based on the findings, conducting hysteroscopy in infertile women who are candidates of laparoscopy and have normal uterine cavities in HSG can result in recognizing some cases of uterine pathologies which influence the outcomes of future pregnancies is not dependent upon the patient’s age, menstruation time, type and duration of infertility, and result of laparoscopy.

Download Full-text

The prevalence of, and risk factors for, mycoplasma genitalium infection among infertile women in Ibadan: A cross-sectional study

International Journal of Reproductive BioMedicine ◽

10.29252/ijrm.15.10.3 ◽

2017 ◽

Vol 15 (10) ◽

pp. 613-618

Author(s):

Tinuade Adesola Ajani ◽

Timothy A Olusesan Oluwasola ◽

Mustapha A Ajani ◽

Rasheed Ajani Bakare ◽

◽

...

Keyword(s):

Risk Factors ◽

Mycoplasma Genitalium ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Infertile Women

Download Full-text

Prevalence of Fibromyalgia in Infertile Women

Journal of the Faculty of Medicine Baghdad ◽

10.32007/jfacmedbagdad.604700 ◽

2019 ◽

Vol 60 (4) ◽

pp. 228-233

Author(s):

Russul A. Shakir ◽

Ala H. Badr ◽

Nizar Abdulateef Jassim ◽

Jasmine A. Hummadi

Keyword(s):

General Population ◽

Musculoskeletal Pain ◽

Cross Sectional Study ◽

Sexually Active ◽

Functional Disorder ◽

Sectional Study ◽

Cross Sectional ◽

Infertile Women ◽

Child Bearing ◽

Is Failure

Background: Fibromyalgia is a functional disorder of growing importance characterized by chronic widespread musculoskeletal pain. It frequently affects women of child bearing age. Infertility is failure to achieve pregnancy within a 12 month period for sexually active individuals under 35 years of age and failure to conceive within a 6 months period for those over 35 years, which can have a major psychosocial impact on the affected person’s life. Objectives: To estimate the prevalence of fibromyalgia among a sample of infertile women; and to study its relationship with age, length of marriage, duration and type of infertility. Patients and Methods: A cross-sectional study was conducted in Kamal Al-Samarraee Infertility Center & Infertility Clinic in Baghdad Teaching Hospital on 202 infertile women. Fibromyalgia was diagnosed according to 2012 Canadian Guidelines. Results: Fibromyalgia was reported in 48 women (23.8%). There was a significant association between fibromyalgia and age (P=0.023), longer duration of marriage (P=0.001) and longer duration of infertility (P=0.04), but no significant association with type of infertility whether primary or secondary (P=0.32). Conclusions: The prevalence of fibromyalgia among infertile women was higher than reported in the general population and its occurrence was significantly associated with age, longer duration of marriage and infertility.

Download Full-text

Success Rates of Vaginal Sonography and Hysteroscopy for Diagnosis of Intrauterine Pathologies in Female Infertility

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2018/v25i330102 ◽

2019 ◽

pp. 1-8

Author(s):

Mahnaz Yavangi ◽

Marzieh Farimani ◽

Firozeh Zonoori ◽

Nooshin Mohammadpour ◽

Mohamad Ali Dayani

Keyword(s):

Endometrial Hyperplasia ◽

Cross Sectional Study ◽

Standard Test ◽

Female Infertility ◽

Transvaginal Sonography ◽

Success Rates ◽

Sectional Study ◽

Cross Sectional ◽

Infertile Women ◽

Vaginal Sonography

Background and Aim: Uterine anatomical pathologies play important roles in causing female infertility. This study was conducted to survey the efficiency of hysteroscopy and vaginal sonography in detecting the intrauterine pathologies in infertile women. Methods: This cross-sectional study was conducted on all the infertile women referring to the Endometriosis Research Center between December 22, 2013 and August 22, 2015. Forty five women were recruited and the data on the examinations of uterine lesions were analyzed by transvaginal sonography (TVS), hysteroscopy, and pathology as the standard test. Data analysis was conducted by SPSSv16 using t-test and Mann-Whitney test, and the sensitivity and specificity were measured with reference to the standard test. Findings: For diagnosing polyp, endometrial hyperplasia, and myoma, TVS showed the 75%, 25%, and 85.71% sensitivity, respectively, and specificity of 92.30%, 92.30%, and 56.97% respectively. For them, hysteroscopy showed the 60%, 75%, and 75.71% sensitivity respectively, and specificity of 71.65%, 30.92%, and 56.97% respectively. Conclusion: According to the findings of this study, the sensitivity of TVS and hysteroscopic findings in diagnosing uterine pathologies is relatively high, but the sensitivity of TVS was low to diagnosis of endometrial hyperplasia.

Download Full-text

The Impact of Infertility on Various Aspects of Women's Lives in Comparison With Tubal Ligation Control: A Cross-sectional Study

10.21203/rs.3.rs-38747/v1 ◽

2020 ◽

Author(s):

Mahnaz Ashrafi ◽

Shahideh Jahanian Sadatmahalleh ◽

Negin Mirzaei ◽

Jahangiri ◽

Samaneh Youseflu

Keyword(s):

Body Image ◽

Self Esteem ◽

Cross Sectional Study ◽

Anxiety And Depression ◽

Sectional Study ◽

Cross Sectional ◽

Infertile Women ◽

Significant Difference ◽

Women's Lives ◽

Anxiety Depression

Abstract Background The aim of this study is to assess anxiety, depression, body image, self-esteem, sexual function (SF), and quality of life (QoL) in infertile women in Iran and to compare the results with fertile women (used a condom) and those with tubal ligation (TL) (as control groups). Methods This cross-sectional study was carried out on infertile women, women who had undergone TL (control 1), and women who had used a condom (control 2) (200 women in each group). They were selected from the Royan Institute in Tehran (Iran) and a number of health care centers in Tehran (Iran) from May 2017 to February 2019. The subjects were asked to fill out the Short Form Health Survey (SF-12), Female Sexual Function Index (FSFI), Hospital Anxiety and Depression Scale (HADS), Body Image Concern Inventory (BICI), and Rosenberg’ Self-Esteem Scale (RSES). One-way ANOVA was used to find the statistical differences between the three groups. Results All mean values FSFI were found to be lower in the TL women and the differences between the three groups were statistically significant in all domains. Women with TL had more female sexual dysfunction (FSD) (22.43 ± 5.30 vs 24.79 ± 4.74 vs 28.03 ± 3.29, P˂0.001). There was a significant difference between the three groups in SF-12 scores (76.59 ± 13.14 vs 68.49 ± 14.47 vs 78.87 ± 12.62, P˂0.001). Also, there was a significant difference between the three groups in anxiety, depression, and total scores HADS (P˂0.001). Infertile women had lower body image (P˂0.05) and self-esteem was lower in the TL group (P˂0.05). Conclusions Our findings reveal the adverse effects of TL on the anxiety and depression, sexual life, body image, and QoL of women. It is recommended that the awareness and knowledge of health-care professionals regarding the side-effects of TL in the above-mentioned aspects of women’s lives should be increased and discussed with patients.

Download Full-text