scholarly journals AMH and AMHR2 Polymorphisms and AMH Serum Level Can Predict Assisted Reproduction Outcomes: A Cross-Sectional Study

2015 ◽  
Vol 35 (4) ◽  
pp. 1401-1412 ◽  
Author(s):  
Carla Peluso ◽  
Fernando L.A. Fonseca ◽  
Guilherme G. Gastaldo ◽  
Denise M. Christofolini ◽  
Emerson Barchi Cordts ◽  
...  
Keyword(s):  
Serum Level ◽  
Assisted Reproduction ◽  
Controlled Ovarian Hyperstimulation ◽  
Cross Sectional Study ◽  
Human Reproduction ◽  
Ovarian Hyperstimulation ◽  
Sectional Study ◽  
Cross Sectional ◽  
Infertile Women ◽  
Assisted Reproductive Treatment

Background: In human assisted reproduction, the ovarian response to exogenous recombinant Follicle-stimulating Hormone (FSH) therapy is variable and difficult to predict. The standard protocol of ovarian hyperstimulation can result in satisfactory response; however, an unsatisfactory response necessitates FSH dose adjustment or results in ovarian hyperstimulation syndrome (OHSS). Polymorphisms in AMH and AMHR2 genes appear to affect hormone biological activities, thus affecting follicle recruitment and development, leading to infertility. We aimed to evaluate AMH and AMHR2 polymorphisms in infertile women, and correlate those findings with AMH, FSH and estradiol serum level response to controlled ovarian hyperstimulation (COH), as well as assisted reproduction outcomes. Methods: A cross-sectional study comprising 186 infertile women that underwent one cycle of high complexity assisted reproductive treatment. Blood samples were collected and a TaqMan assay was used for AMH G146T/rs10407022 and AMHR2 A-482G/rs2002555, A10G/rs11170555, C1749G/rs2071558 and G4952A/rs3741664 genotyping, and FSH, estradiol and AMH levels were measured. The findings were correlated to human reproduction outcomes. Results: AMH rs10407022 and AMHR2 rs2002555 polymorphisms were not associated with hormonal measurements, whereas AMHR2 rs11170555 and rs3741664 were positively associated with AMH, estradiol and FSH levels. The genotype distribution of AMH and AMHR2 genes according to Controlled Ovarian Hyperstimulation did not show a positive association. However, an association with AFC, degree of oocyte maturation (allele G of AMHR2 rs2071558) the number of embryos produced (alleles T and G of AMH rs10407022 and AMHR2 rs2002555, respectively) and frozen embryo (allele G of AMHR2 rs11170555) were found to be statistically associated. Considering COH, serum AMH and AFC were a positive predictor to OHSS. Regarding serum AMH and assisted reproduction outcomes, a positive correlation with all variables studied was found. Comparing AFC and AMH as predictors of human reproduction outcomes, the AFC was less effective than serum AMH. Considering pregnancy rates, no marker was positively associated. Conclusion: AMHR2 polymorphisms were associated with estradiol, AMH and FSH measurements, as well as number and quality of embryos, while AMH polymorphisms was associated with number of embryos produced. Serum AMH was correlated with nearly all variables analyzed in assisted reproductive treatment, demonstrating that it represents a better biomarker of OHSS and human reproduction outcomes compared to AMH and AMHR2 polymorphisms.

scholarly journals The Relationships Between Serum DHEA-S and AMH Levels in Infertile Women: A Retrospective Cross-Sectional Study

2021 ◽  
Vol 10 (6) ◽  
pp. 1211
Author(s):  
Li-Te Lin ◽  
Kuan-Hao Tsui
Keyword(s):  
Generalized Linear Models ◽  
Large Scale ◽  
Linear Models ◽  
Positive Association ◽  
Cross Sectional Study ◽  
Dehydroepiandrosterone Sulphate ◽  
Sectional Study ◽  
Cross Sectional ◽  
Infertile Women ◽  
The Relationship

The relationship between serum dehydroepiandrosterone sulphate (DHEA-S) and anti-Mullerian hormone (AMH) levels has not been fully established. Therefore, we performed a large-scale cross-sectional study to investigate the association between serum DHEA-S and AMH levels. The study included a total of 2155 infertile women aged 20 to 46 years who were divided into four quartile groups (Q1 to Q4) based on serum DHEA-S levels. We found that there was a weak positive association between serum DHEA-S and AMH levels in infertile women (r = 0.190, p < 0.001). After adjusting for potential confounders, serum DHEA-S levels positively correlated with serum AMH levels in infertile women (β = 0.103, p < 0.001). Infertile women in the highest DHEA-S quartile category (Q4) showed significantly higher serum AMH levels (p < 0.001) compared with women in the lowest DHEA-S quartile category (Q1). The serum AMH levels significantly increased across increasing DHEA-S quartile categories in infertile women (p = 0.014) using generalized linear models after adjustment for potential confounders. Our data show that serum DHEA-S levels are positively associated with serum AMH levels.

scholarly journals RELATIONSHIP BETWEEN DEPRESSION, ANXIETY AND STRESS WITH QUALITY OF LIFE OF INFERTILE COUPLES

2020 ◽  
pp. 1-3
Author(s):  
Jisha M. ◽  
Dr Assuma Beevi.T. M.
Keyword(s):  
Quality Of Life ◽  
Cross Sectional Study ◽  
Social Effects ◽  
Anxiety And Depression ◽  
Sectional Study ◽  
Cross Sectional ◽  
Infertile Women ◽  
Stress Scale ◽  
Infertile Couples

Introduction: Psychological and social effects of infertility may cause decline in the quality of life of infertile couples. A cross sectional study was conducted among 100 infertile couples, to find out the association between level of stress, anxiety and depression with their quality of life. Materials and methods: Data was collected using demographic and fertility information questionnaire, depression anxiety and stress scale (DASS-42) and fertility quality of life (fertiQol-malayalam). Results: Infertile couples experiences higher levels of depression, anxiety and stress and it is more among women,(depression-(15.36 +_ 9.23), stress(16.3+-7.52) anxiety (9.36+_6.33) than men (depression(12.52+_10.30 )(P=0.030), stress(12.84+_ 7.94 )(P=0-002 ) anxiety(7.50+_5-55). Levels of depression, anxiety and stress have significant negative relation with their quality of life. Infertile women has significantly lower quality of life (P= 0.002) than men. Conclusion: Interventions, to reduce depression, anxiety and stress among infertile couples may be helpful to improve their quality of life.

Validity of The Fertility Quality of Life (FertiQol) Questionnaire in Indonesian Infertile Women

KnE Medicine ◽  
2017 ◽  
Vol 1 (1) ◽  
pp. 202
Author(s):  
Muhammad D. Priangga ◽  
Gita Pratama ◽  
Mila Maidarti ◽  
Achmad K. Harzif ◽  
Budi Wiweko
Keyword(s):  
Quality Of Life ◽  
Statistical Analysis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Validity And Reliability ◽  
Cross Sectional ◽  
Infertile Women ◽  
The Mean ◽  
Preliminary Study

<p><strong>Introduction</strong></p><p>Infertility in Indonesia has an estimated prevalence as high as 22.3%, with the nature of the problem and its treatment could be devastating, it could affect quality of life and vice versa influence successful of the treatment. The Fertility Quality of Life (FertiQol) Questionnaire was specifically designed for infertility couples and has been demonstrated to have good properties. Studies in several countries has showed consistency in validity and reliability of the questionnaire. Precedently there has been no published study about Fertiqol in Indonesia, this preliminary study is to measure validity and reliability of FertiQol questionnaire among Indonesian infertility women.</p><p><br /> <strong>Material &amp; Methods</strong></p><p>This is a cross-sectional study, a written Fertiqol Questionnaire Indonesian version (www.Fertiqol.org) were distribute to Infertility clinic in Cipto Mangunkusumo General Hospital, total of 129 women completed the questionnaire. Statistical analysis used SPSS version 23.0. The questionnaire were tested for validity with Pearson’s correlation with two tailed and Cronbach α coefficient for reliability.<br /> <strong></strong></p><p><strong>Results</strong></p><p>FertiQol were completed by 129 women with infertility problem. The mean of total FertiQol score was 70.49±11.44, score for emotional, mind/body, relational, environment and tolerability was respectively 63.79±18.86; 66.05±18.22; 75.19.±15.11; 68.99±18.63; 75.64±16.55; 66.23±19.17. Reliability of Fertiqol was high (Cronbach a &gt; 0.70) with every item of questionnaires was valid ( r&gt; 0.1729).<br /> <strong></strong></p><p><strong>Conclusion</strong></p><p>This study showed that FertiQol Indonesian version are valid and reliable in measured quality of life among infertility women in Indonesia.</p>

scholarly journals The prevalence of, and risk factors for, mycoplasma genitalium infection among infertile women in Ibadan: A cross-sectional study

2017 ◽  
Vol 15 (10) ◽  
pp. 613-618
Author(s):  
Tinuade Adesola Ajani ◽  
Timothy A Olusesan Oluwasola ◽  
Mustapha A Ajani ◽  
Rasheed Ajani Bakare ◽  
◽  
...  
Keyword(s):  
Risk Factors ◽  
Mycoplasma Genitalium ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Infertile Women

scholarly journals The Level of 8-OHdG Serum was Higher in Women with Blighted Ovum

2014 ◽  
pp. 18-21
Author(s):  
I Made Mahadinata Putra ◽  
I Gede P Surya
Keyword(s):  
Serum Level ◽  
Venous Blood ◽  
Normal Pregnancy ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Hospital Data ◽  
Cross Sectional ◽  
Independent Test ◽  
The Difference ◽  
Blighted Ovum

Objective: To determine the difference of 8-hydroxy-2-deoxyguanocyne (8-OHdG) serum level in women experiencing blighted ovum and women with normal pregnancy. Method: This was a cross sectional study with 82 samples, divided into two groups. Thirty two cases of blighted ovum and 51 cases of normal pregnancies, with 7-12 weeks gestational age. The examination of 8-OHdG serum level, was performed with the venous blood taken from the cubiti veins, and its 8-OHdG serum quantities were than examined at the Pathology Lab. at Sanglah General Hospital. Data was analyzed with the Shapiro Wilk Test and the t independent test with alpha 0.05. Result: The average 8-OHdG serum level in women with blighted ovum and normal pregnancies were 0.177 (SD 0.06) ng/ml and 0.111 (SD 0.01)ng/ml, and significantly different (p<0.05). The cut off value of 8-OHdG serum level was 0.138 ng/ml with sensitivity of 96.1% and specificity of 80.6%. Conclusion: The level of 8-OHdG serum was higher in women with blighted ovum than in women with normal pregnancies.  Keywords: 8-OHdG serum level, blighted ovum, and normal pregnancy.

scholarly journals Vitamin D Supplementation in Tuberculosis Patients: A Cross Sectional Study

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Dina Keumala Sari ◽  
Nurfida Khairina Arrasyid ◽  
Y. S. Harahap
Keyword(s):  
Vitamin D ◽  
Serum Level ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Vitamin D Supplementation ◽  
Sectional Study ◽  
Cross Sectional ◽  
Tuberculosis Patients ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Previous studies have not been able to show with certainty the effect of vitamin D supplementation in tuberculosis patients. The objective of this study is to determine whether vitamin D supplementation to patients with tuberculosis could influence 25-hydroxyvitamin D (25(OH)D) and calcium serum levels. The results, after 28 days, the vitamin D supplementation showed significant increase of 25(OH)D serum level at the end point (p=0.001), but not for the calcium serum level (p=0.3). The Conclusions is supplementation with 1,000 IU vitamin D per day increased the 25(OH)D serum level but there was no association with the calcium serum level.

scholarly journals Prevalence of Fibromyalgia in Infertile Women

2019 ◽  
Vol 60 (4) ◽  
pp. 228-233
Author(s):  
Russul A. Shakir ◽  
Ala H. Badr ◽  
Nizar Abdulateef Jassim ◽  
Jasmine A. Hummadi
Keyword(s):  
General Population ◽  
Musculoskeletal Pain ◽  
Cross Sectional Study ◽  
Sexually Active ◽  
Functional Disorder ◽  
Sectional Study ◽  
Cross Sectional ◽  
Infertile Women ◽  
Child Bearing ◽  
Is Failure

Background: Fibromyalgia is a functional disorder of growing importance characterized by chronic widespread musculoskeletal pain. It frequently affects women of child bearing age. Infertility is failure to achieve pregnancy within a 12 month period for sexually active individuals under 35 years of age and failure to conceive within a 6 months period for those over 35 years, which can have a major psychosocial impact on the affected person’s life. Objectives: To estimate the prevalence of fibromyalgia among a sample of infertile women; and to study its relationship with age, length of marriage, duration and type of infertility. Patients and Methods: A cross-sectional study was conducted in Kamal Al-Samarraee Infertility Center & Infertility Clinic in Baghdad Teaching Hospital on 202 infertile women. Fibromyalgia was diagnosed according to 2012 Canadian Guidelines. Results: Fibromyalgia was reported in 48 women (23.8%). There was a significant association between fibromyalgia and age (P=0.023), longer duration of marriage (P=0.001) and longer duration of infertility (P=0.04), but no significant association with type of infertility whether primary or secondary (P=0.32). Conclusions: The prevalence of fibromyalgia among infertile women was higher than reported in the general population and its occurrence was significantly associated with age, longer duration of marriage and infertility.

scholarly journals 25(OH)D Inadequacy Has Different Pathway with VEGF in Increases the Risk of Severe Preeclampsia

2015 ◽  
Vol 23 (2) ◽  
pp. 42
Author(s):  
Hanifa Erlin Damayanti ◽  
Aditiawarman Aditiawarman
Keyword(s):  
Vitamin D ◽  
Serum Level ◽  
Vitamin D Deficiency ◽  
Sandwich Elisa ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Chemiluminescent Immunoassay ◽  
Risk Of Preeclampsia

Objectives: To identify in vivo correlation between 25(OH)D and VEGF in severe preeclampsia.Materials and Methods: A case control, cross sectional study of 36 pregnant women which consist of 18 patients with preeclampsia and 18 patients as control with gestational age-matched. We perform 25(OH)D serum examination by chemiluminescent immunoassay (CLIA) and VEGF serum examination by sandwich ELISA to all patients.Results: All patients are in 25(OH)D insufficiency and deficiency state. Both maternal 25(OH)D and VEGF levels were inversely associated with the risk of preeclampsia (both P<0.05). There is no correlation between 25(OH)D serum level and VEGF serum level (P=0,629).Conclusion: Maternal vitamin D deficiency is associated with increased preeclampsia risk. However, our data do not support the hypothesis that the association between vitamin D deficiency and preeclampsia is mediated by impaired level of VEGF.

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