ADP-induced platelet aggregation in acute ischemic stroke patients on aspirin therapy

2008 ◽  
Vol 15 (12) ◽  
pp. 1304-1308 ◽  
Author(s):  
J.-K. Cha ◽  
H.-W. Jeon ◽  
M.-J. Kang
Keyword(s):  
Ischemic Stroke ◽  
Platelet Aggregation ◽  
Acute Ischemic Stroke ◽  
Aspirin Therapy ◽  
Stroke Patients

scholarly journals Frequency of Aspirin Resistance in Ischemic Stroke Patients and Healthy Controls from Colombia

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Alejandro Roman-Gonzalez ◽  
Carlos Andrés Naranjo ◽  
Walter D. Cardona-Maya ◽  
Dionis Vallejo ◽  
Francisco Garcia ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Platelet Aggregation ◽  
Univariate Analysis ◽  
Aspirin Resistance ◽  
Aspirin Therapy ◽  
Stroke Recurrence ◽  
Healthy Controls ◽  
Test Results ◽  
Stroke Patients ◽  
Ischemic Cerebrovascular Disease

Objective. To evaluate the aspirin resistance prevalence in patients with previous ischemic cerebrovascular disease undergoing aspirin therapy for secondary prevention. Materials and Methods. Three hundred fifty patients presenting ischemic strokes and 100 healthy controls under aspirin treatment were evaluated using the optic platelet aggregation test. Results. Aspirin resistance was found in 7.4% of the patients with ischemic stroke and 4% of controls. Aspirin resistance was associated with stroke recurrence in univariate analysis ( p = 0.004 ). Aspirin resistance was not associated with smoking, diabetes, or hypercholesterolemia. Conclusion. Aspirin resistance is present in Colombian patients with ischemic stroke as well as in healthy controls.

scholarly journals CHANGES IN PLATELET AGGREGATION AND NIHSS AFTER ANTI-PLATELET THERAPY FOR ACUTE ISCHEMIC STROKE PATIENTS AT H. ADAM MALIK GENERAL HOSPITAL MEDAN

2020 ◽  
Vol 7 (8) ◽  
pp. 45-50
Keyword(s):  
Ischemic Stroke ◽  
Platelet Aggregation ◽  
Acute Ischemic Stroke ◽  
General Hospital ◽  
Significant Relationship ◽  
Cerebral Arteries ◽  
Platelet Activity ◽  
Stroke Patients ◽  
Positive Direction ◽  
Anti Platelet Therapy

Background: Acute ischemic stroke is caused by blockage of the cerebral arteries due to thrombus originating from excessive clotting of platelets. Increased platelet activity impacts the risk of atherothrombosis. The clinical impact of this blockage can be seen in changes in platelet aggregation and NIHSS after anti-platelet administration. Objectives: This study aims to determine changes in platelet aggregation and NIHSS after administration of anti-platelet therapy in acute ischemic stroke patients. Methods: This study was a Quasi Experimental Study with the method of Pre and Post-test Only Group selected by consecutive non-random sampling technique, in which patients diagnosed with ischemic stroke treated at H Adam Malik General Hospital Medan. The study began from March to July 2020. Results: The study was conducted on 38 samples consisting of 18 men and 20 women with an average age of 58.92(±7.539) years. There was a significant change between platelet aggregation and NIHSS (p<0.001). There was a significant relationship between platelet aggregation with NIHSS the first day before the administration of anti platelets (p=0.018) and correlation test (r=0.339) positive direction (unidirectional). There was no significant relationship between platelet aggregation with NIHSS in the seventh day after anti platelet administration (p=0.394). Conclusions: There were significant changes between platelet aggregation and NIHSS scores. There was a significant relationship between platelet aggregation and NIHSS the first day before anti platelet administration. There was no significant relationship between platelet aggregation and NIHSS in the seventh day after anti platelet administration.

scholarly journals Management of acute ischemic stroke in patients with COVID-19 infection: Report of an international panel

2020 ◽  
Vol 15 (5) ◽  
pp. 540-554 ◽  
Author(s):  
Adnan I Qureshi ◽  
Foad Abd-Allah ◽  
Fahmi Al-Senani ◽  
Emrah Aytac ◽  
Afshin Borhani-Haghighi ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Current Knowledge ◽  
Intravenous Thrombolysis ◽  
Adult Patients ◽  
World Health ◽  
Stroke Patients ◽  
International Panel ◽  
Health Organization ◽  
Tract Infections

Background and purpose On 11 March 2020, World Health Organization (WHO) declared the COVID-19 infection a pandemic. The risk of ischemic stroke may be higher in patients with COVID-19 infection similar to those with other respiratory tract infections. We present a comprehensive set of practice implications in a single document for clinicians caring for adult patients with acute ischemic stroke with confirmed or suspected COVID-19 infection. Methods The practice implications were prepared after review of data to reach the consensus among stroke experts from 18 countries. The writers used systematic literature reviews, reference to previously published stroke guidelines, personal files, and expert opinion to summarize existing evidence, indicate gaps in current knowledge, and when appropriate, formulate practice implications. All members of the writing group had opportunities to comment in writing on the practice implications and approved the final version of this document. Results This document with consensus is divided into 18 sections. A total of 41 conclusions and practice implications have been developed. The document includes practice implications for evaluation of stroke patients with caution for stroke team members to avoid COVID-19 exposure, during clinical evaluation and performance of imaging and laboratory procedures with special considerations of intravenous thrombolysis and mechanical thrombectomy in stroke patients with suspected or confirmed COVID-19 infection. Conclusions These practice implications with consensus based on the currently available evidence aim to guide clinicians caring for adult patients with acute ischemic stroke who are suspected of, or confirmed, with COVID-19 infection. Under certain circumstances, however, only limited evidence is available to support these practice implications, suggesting an urgent need for establishing procedures for the management of stroke patients with suspected or confirmed COVID-19 infection.

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