scholarly journals CHANGES IN PLATELET AGGREGATION AND NIHSS AFTER ANTI-PLATELET THERAPY FOR ACUTE ISCHEMIC STROKE PATIENTS AT H. ADAM MALIK GENERAL HOSPITAL MEDAN

2020 ◽  
Vol 7 (8) ◽  
pp. 45-50
Keyword(s):  
Ischemic Stroke ◽  
Platelet Aggregation ◽  
Acute Ischemic Stroke ◽  
General Hospital ◽  
Significant Relationship ◽  
Cerebral Arteries ◽  
Platelet Activity ◽  
Stroke Patients ◽  
Positive Direction ◽  
Anti Platelet Therapy

Background: Acute ischemic stroke is caused by blockage of the cerebral arteries due to thrombus originating from excessive clotting of platelets. Increased platelet activity impacts the risk of atherothrombosis. The clinical impact of this blockage can be seen in changes in platelet aggregation and NIHSS after anti-platelet administration. Objectives: This study aims to determine changes in platelet aggregation and NIHSS after administration of anti-platelet therapy in acute ischemic stroke patients. Methods: This study was a Quasi Experimental Study with the method of Pre and Post-test Only Group selected by consecutive non-random sampling technique, in which patients diagnosed with ischemic stroke treated at H Adam Malik General Hospital Medan. The study began from March to July 2020. Results: The study was conducted on 38 samples consisting of 18 men and 20 women with an average age of 58.92(±7.539) years. There was a significant change between platelet aggregation and NIHSS (p<0.001). There was a significant relationship between platelet aggregation with NIHSS the first day before the administration of anti platelets (p=0.018) and correlation test (r=0.339) positive direction (unidirectional). There was no significant relationship between platelet aggregation with NIHSS in the seventh day after anti platelet administration (p=0.394). Conclusions: There were significant changes between platelet aggregation and NIHSS scores. There was a significant relationship between platelet aggregation and NIHSS the first day before anti platelet administration. There was no significant relationship between platelet aggregation and NIHSS in the seventh day after anti platelet administration.

Abstract 3730: Length Of Hospitalization And Discharge Disposition Among Acute Ischemic Stroke Patients With Moderate To Severe Stroke by Treatment

Stroke ◽  
2012 ◽  
Vol 43 (suppl_1) ◽  
Author(s):  
Steven A Koehler ◽  
Maxim Hammer ◽  
Vivek Reddy ◽  
Houhammad Jumaa ◽  
Syed Zaidi ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Length Of Stay ◽  
Acute Ischemic Stroke ◽  
Treatment Modality ◽  
Cerebral Arteries ◽  
Stroke Patients ◽  
Term Care ◽  
Severe Stroke ◽  
Discharge Disposition ◽  
Significant Difference

Background: Data regarding length of stay and discharge disposition in patients with moderate to severe stroke are scarce. We sought to determine Length of Stay (LoS) in a consecutive group of patients admitted at a large academic center and assess for any possible difference in LoS at discharge by treatment modality received and by vessels occlusion status. Methods: Retrospective review of a database comprising acute ischemic stroke patients admitted to our center between 1/1/2009-3/31/2011. Patient Demographics, treatment modality (IV thrombolytic tissue plasminogen activator (IVtPA), Endovascular (IA), no thrombolytic (NT), LoS, occlusion of major cerebral arteries and discharge disposition were collected. Inclusion criteria were AIS with admission NIHSS ≥10. Results: A total of 744 patients 361 (48.5%) male, mean age 69.9 years were identified. Treatment modalities: 174 (23%) IVtPA, 177 (24%) IA, 393 (53%) NT. Median NIHSS 16.5 and not significant among the 3 groups (P=.603). Mean LoS was 7.38 days (SD 7.4) with no significant difference between the 3 groups (P=.056). Occlusion to one of the 3 cerebral arteries (ICA, MCA, BA) was: 84% in IVtPA, 100% in IA, 87% in NT. Discharge disposition and LoS by treatment and occlusions are shown in the Table . Among patients treated with IVtPA (n=174) mean LoS was 6.33 days (range 1-27). LoS was significantly longer among those without occlusion vs with any occlusion (P=.001). Among patients that received IA (n=177) mean LoS was 8.21 days (range 0-74). Among patients received NT (n=393) the mean LoS was 7.47 days (range 0-64). Conclusions: Thrombolytic therapy (IV or EV) in patients with strokes is not associated with longer hospitalizations duration. A significant difference between death rates in patients receiving IA thrombolytic (22%) compared to IV (32%) or NT (30%) was found with fewer death among those that received IA (P= .008). Patients discharged to long term care facilities have regardless of treatment longer LoS (12.41v 6.14) (P>.000).

Abstract TP70: Collateral Scoring of Cerebral Arteries Predicts Perfusion and Diffusion in Acute Ischemic Stroke Patients Undergoing Thrombectomy

Stroke ◽  
2019 ◽  
Vol 50 (Suppl_1) ◽  
Author(s):  
Varun Shah ◽  
Nguyen Hoang ◽  
David Dornbos ◽  
Victoria Schunemann ◽  
Shahid Nimjee ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Cerebral Arteries ◽  
Stroke Patients ◽  
And Diffusion

scholarly journals ASSOCIATION BETWEEN BLOOD PRESSURE VARIABILITY AND EARLY NEUROLOGICAL DETERIORATION IN ACUTE ISCHEMIC STROKE PATIENTS

2020 ◽  
Vol 7 (8) ◽  
pp. 94-99
Keyword(s):  
Blood Pressure ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Significant Relationship ◽  
Blood Pressure Variability ◽  
Stroke Severity ◽  
Stroke Patients ◽  
Cross Sectional ◽  
Exact Test ◽  
Treatment Data

Background: Variability in blood pressure is a predictor of stroke severity and causes of poor functional outcome. Blood pressure variability is one of the main predictor of the prognosis acute ischemic stroke. Blood pressure variability were independently and linearly associated with the development of early neurologic deterioration (END) in acute ischemic stroke Objective: To determine the association between blood pressure variability and END in acute ischemic stroke patients. Method: This study uses a cross sectional design. Sampling was conducted at H. Adam Malik General Hospital Medan. Samples were taken as many as 40 subjects consecutively. Blood pressure checks were perform every hour for 72 hours then an assessment of the National Institute of Health Stroke Scale (NIHSS) score at admission and the third day of treatment. Data analysis used fisher’s exact test. Results: The demographic characteristics of the study subjects were an average age of 56-<71 years, high school education level, housewife occupation and Batak ethnicity. The mean of maximum systolic blood pressure (SBP) was 151±12.16 mmHg, minimum SBP 123.15±18 mmHg, delta SBP 25.35±10.66 mmHg, maximum diastolic blood pressure (DBP) 79.7±6.01 mmHg, minimum DBP 61.77±7.32 mmHg and delta DBP 17.97±8.48 mmHg. The NIHSS day 1 score had an average of 9.55±6.73, the NIHSS day 3 score was 11.25±7.93. Most subjects experienced END. There is a significant relationship between blood pressure variability and END with a p of 0.03 (p<0.05). Conclusion: There is a significant relationship between blood pressure variability and END in patients with acute ischemic stroke.

scholarly journals MEAN PLATELET VOLUME DI STROK

2016 ◽  
Vol 19 (1) ◽  
pp. 37
Author(s):  
Besse Rosmiati ◽  
Sulina Y Wibawa ◽  
Darmawaty ER
Keyword(s):  
Cohort Study ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Mean Platelet Volume ◽  
Modified Rankin Scale ◽  
Platelet Activity ◽  
Stroke Patients ◽  
Platelet Volume ◽  
P Values ◽  
The Mean

Ischemic stroke is the cause of most cases which occur due to obstruction, this pathogenesis can be caused by the formation of thrombus in the cerebrum blood vessels. Platelet aggregation plays a role in the pathogenesis of thromboembolic cerebrovascular disease. Platelets size, measured as Mean Platelet Volume (MPV) is a marker of platelet function and is associated with the indicator of platelet activity. Several studies have found that there was an increased of MPV in acute ischemic stroke while the correlation with the severity and outcome of stroke was still controversial. The aim of study is to determine the MPV and their association with outcomes in acute ischemic stroke patients. A cohort study during May up to July 2010 was carried out, the researchers measured MPV and analyze their correlation with its outcome using modified Rankin scale score 10 days after the onset in 33 acute ischemic stroke patients. The mean of MPV for the first three days of the onset was 8.9 fl, on the 5th day was increased up to 9.4 but at the 10th day of onset the MPV remains the same value as the 5th day. The MPV of first three days and 5th day have a positive correlation, but insignificant with their outcome, with p values 0.158 and 0.06, respectively. From this study can be concluded that the increased of MPV on the fifth day onset did not have any significant correlation with the outcome of acute ischemic stroke illness.

Characteristics and the Fate of Intraluminal Thrombus of the Intracranial and Extracranial Cerebral Arteries in Acute Ischemic Stroke Patients

2009 ◽  
Vol 62 (2) ◽  
pp. 72-78 ◽  
Author(s):  
Hye-Yeon Choi ◽  
Byoung Suk Ye ◽  
Seong Hwan Ahn ◽  
Hyun Ji Cho ◽  
Dong-Joon Kim ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Cerebral Arteries ◽  
Stroke Patients ◽  
Intraluminal Thrombus

scholarly journals HUBUNGAN KADAR S100B SERUM TERHADAP LUARAN KLINIS NEUROLOGIS PASIEN STROKE ISKEMIK AKUT

2018 ◽  
Vol 36 (1) ◽  
Author(s):  
Windri Kartikasari ◽  
Retnaningsih Retnaningsih ◽  
Amin Husni
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Significant Relationship ◽  
Serum Levels ◽  
Confounding Factors ◽  
Inclusion Criteria ◽  
Stroke Patients ◽  
Nihss Score ◽  
Cohort Design ◽  
Relationship Of

  RELATIONSHIP OF S100B SERUM WITH NEUROLOGIC CLINICAL OUTCOME IN ACUTE ISCHEMIC STROKE PATIENTSABSTRACTIntroduction: Biomarker levels of S100B serum have a correlation with the degree of damage to brain tissue so that it can be used as a marker to determine the clinical outcomes of patients with acute ischemic stroke.Aims: To determine the association of S100B serum levels 72 hours of onset to NIHSS score changes in acute ischemic stroke patients. Determine the association of confounding factors that affecting NIHSS score changes and S100B serum levels.Method: This research is an analytic observational study with prospective cohort design. Subjects were patients diagnosed with acute ischemic stroke who meet the inclusion criteria. This study used bivariate and multivariate analysis.Result: There was a significant relationship between S100B serum levels and changes in the NIHSS score. There was a significant relationship between BMI status and NIHSS score changes. There was a significant relationship between S100B serum levels with age ≥65 years, with hypertension, and with dyslipidemia to NIHSS score changes. There was a significant relationship between S100B serum levels in subject ≥65 years old with hypertension to NIHSS score changes. There was no significant relationship between S100B serum levels with dyslipidemia, hypertension, and diabetes mellitus to NIHSS score changes.Discussion: In this study, S100B serum levels were significant correlated with NIHSS score changes in acute ischemic stroke patients. There was a correlation  between S100B serum levels with age ≥65 years, hypertension, dyslipidemia. In subjects with age ≥65 years old and hypertension, S100 serum levels was significantly associated with NIHSS score changes in acute ischemic stroke patients.Keywords: Confounding factors, NIHSS score changes, S100B serumABSTRAKPendahuluan: Kadar penanda serum S100B berkorelasi dengan derajat kerusakan jaringan otak sehingga dapat digunakan sebagai petanda untuk mengetahui luaran klinis pasien stroke iskemik akut.Tujuan: Mengetahui hubungan kadar S100B serum 72 jam pasca-onset terhadap perubahan skor NIHSS pada pasien stroke iskemik akut dan faktor-faktor menjadi perancu.Metode: Penelitian ini merupakan penelitian observasional analitik dengan pendekatan kohort prospektif. Subjek adalah pasien yang didiagnosis stroke iskemik akut pertama kali. NIHSS dikatakan membaik jika perubahan skor antara hari ke-7 dan 3 perawatan ≥2. Analisis bivariat dilanjutkan dengan analisis multivariat dilakukan antara NIHSS dengan kadar S100B dan faktor-faktor perancu lainnya.Hasil: Didapatkan hubungan bermakna antara kadar S100B serum dengan perubahan  skor NIHSS. Didapatkan hubungan bermakna antara status BMI dengan perubahan skor NIHSS. Terdapat hubungan bermakna antara kadar S100B serum dengan umur ≥65 tahun, dengan hipertensi, dan dengan dislipidemia terhadap perubahan skor NIHSS. Terdapat hubungan bermakna antara kadar S100B serum pada subjek umur ≥65 tahun dengan hipertensi terhadap perubahan skor NIHSS. Tidak terdapat hubungan antara kadar S100B serum dengan dislipidemia, hipertensi, dan DM terhadap perubahan skor NIHSS.Diskusi: Terdapat hubungan antara kadar S100B serum terhadap perubahan skor NIHSS pasien stroke iskemik akut. Terdapat hubungan antara kadar S100B serum dengan dengan umur ≥ 65 tahun, hipertensi, dan dislipidemia. Pada umur ≥65 tahun dengan hipertensi, kadar S100B berhubungan terhadap perubahan skor NIHSS pasien stroke iskemik akut.Kata kunci: Faktor-faktor perancu, perubahan skor NIHSS, S100B serum  

Correlation of Platelet Indices with Severity of Acute Ischemic Stroke in Non-Diabetic and NonHypertensive Patients in Hubli, Karnataka

2021 ◽  
Vol 8 (33) ◽  
pp. 3078-3083
Author(s):  
Seetaram N.K. ◽  
Gayatri B.H. ◽  
Chandrashekhar Kachapur ◽  
Shruti N. Kulkarni
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Mean Value ◽  
Motor Deficit ◽  
Platelet Activity ◽  
Stroke Patients ◽  
Platelet Factor ◽  
Distribution Width ◽  
Platelet Indices ◽  
Comprehension Deficit

BACKGROUND Platelet size, measured as mean platelet volume (MPV), is a marker of platelet function and is positively associated with indicators of platelet activity, including aggregation and release of thromboxane A2, platelet factor 4, and thromboglobulin.1 Larger platelets are metabolically more active, produce more prothrombotic factors, aggregate more easily & act as index of homeostasis and its dysfunction thrombosis.2 The purpose of this study was to examine the relationship between platelet indices and stroke, as well as its severity and outcome. METHODS This was a prospective observational case control study. This study was conducted with 105 non-diabetic, non-hypertensive ischemic stroke patients who had no history of previous thrombotic events and who had not previously taken any antiplatelet medications. These patients were examined within 24 hours of onset of symptoms and severity of stroke was calculated by Canadian neurological scale (CNS). The results were compared with 105 age and sex match controls. RESULTS Mean age of patients was 61.72 ± 12 and of controls was 62.85 ± 10.68. Based on the CNS score, participants were allocated into two groups; the first group were those who had a comprehension deficit (1st group, 43 patients) and the second group were those without a comprehension deficit (2nd group, 62 patients). Mean values for platelet distribution width (PDW) & MPV in 1st group was 18.329 and 12.55 respectively and in 2nd group was 16.98 and 11.48 respectively. The mean value of PDW and MPV for stroke patients was 17.53 ± 0.76 and 11.92 ± 0.58 and was significantly higher than mean value of PDW & MPV respectively in controls, which were 15.47 ± 0.26 and 10.43 ± 0.23. PDW & MPV was found to be significantly associated with severity of motor deficit. CONCLUSIONS Larger studies may be required to determine its utility in day-to-day clinical practice. However, platelet indices can be used for predicting the severity of deficit in patients of acute ischemic stroke. KEYWORDS Platelet Indices, Stroke

scholarly journals Correlation between atherogenic index of plasma and national institutes of health stroke scale score in acute ischemic stroke patients at Haji Adam Malik general hospital, Medan

2021 ◽  
Vol 9 (10) ◽  
pp. 3057
Author(s):  
Muhammad Zulfikri ◽  
Cut A. Arina ◽  
Chairil A. Batubara
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
General Hospital ◽  
National Institutes Of Health ◽  
Atherogenic Index ◽  
Neurological Deficits ◽  
Stroke Patients ◽  
Atherogenic Index Of Plasma ◽  
Nihss Score ◽  
The Mean

Background: Stroke is the leading cause of morbidity and mortality in Indonesia. Dyslipidemia is one of the main risk factors of ischemic stroke. Atherogenic index of plasma (AIP) is the logarithm of the triglyceride’s plasma ratio concentration to high density lipoprotein cholesterol (HDL-C) plasma concentration. Previous studies showed that the high AIP at hospital admission was associated with deterioration of neurological deficits in patients with acute ischemic stroke.Methods: This is a cross sectional study with 82 sample of acute ischemic stroke subjects that consecutively collected from the medical records of Haji Adam Malik general hospital Medan from January to December 2019, AIP assessment performed at the 1st day of hospitalization and then at the 7th -onset the national institutes of health stroke scale (NIHSS) score assessment was count. Data analysis is conducted with Spearman test.Results: Demographic characteristics showed that most subjects were female (51.2%), at age range between 60 -68 years (30.5%), had high school education level (48.8%), self-employed (35.4%) and Bataknese (68.3%). The mean of AIP was 0.15±0.26 and the mean NIHSS score was 6.70±3.6. There was a positive significant and mild power of correlation between AIP and the NIHSS score (p=0.017; r=0.262).Conclusions: There is a significant relationship between AIP and the NIHSS score. The higher the AIP of acute ischemic stroke patients was associated with the increase in the NIHHS scores. 

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